N-(3-piperidino-1,4-dihydro-1,4-dioxo-2-naphthyl)-4-aminoacetophenone oxime

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(3-piperidino-1,4-dihydro-1,4-dioxo-2-naphthyl)-4-aminoacetophenone oxime
• 英文别名: 2-[4-[(E)-N-hydroxy-C-methylcarbonimidoyl]anilino]-3-piperidin-1-ylnaphthalene-1,4-dione
• 化学式: C₂₃H₂₃N₃O₃
• 分子量: 389.454
• InChiKey: CRTJKGVYNGBLGV-MFKUBSTISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  82
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-(4-acetylphenylamido)-3-piperidino-1,4-naphthoquinone 在 盐酸羟胺 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以65%的产率得到N-(3-piperidino-1,4-dihydro-1,4-dioxo-2-naphthyl)-4-aminoacetophenone oxime
  参考文献：
  名称：

  The interaction of 2-(4-acetylphenylamino)-3-piperidino-1,4-naphthoquinone with hydroxylamine and hydrazines

  摘要：

  With acid catalysts 2-(4'-acetylphenylamino)-3-piperidino-1,4-naphthoquinone reacts with hydroxylamine and aryl hydrazines exclusively at the carbonyl group of its side chain. The products corresponding to the condensation at the naphthoquinone C=O group could not be detected.

  DOI：

  10.1007/bf01558071

文献信息

• The interaction of 2-(4-acetylphenylamino)-3-piperidino-1,4-naphthoquinone with hydroxylamine and hydrazines
  作者：S. V. Rubashko、T. V. Mikhalina、I. Yu. Bagryanskaya、Yu. V. Gatilov

  DOI：10.1007/bf01558071

  日期：1994.6

  With acid catalysts 2-(4'-acetylphenylamino)-3-piperidino-1,4-naphthoquinone reacts with hydroxylamine and aryl hydrazines exclusively at the carbonyl group of its side chain. The products corresponding to the condensation at the naphthoquinone C=O group could not be detected.