Naphthalene-1-sulfonic acid [6-(4-amino-quinazolin-2-ylamino)-hexyl]-amide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Naphthalene-1-sulfonic acid [6-(4-amino-quinazolin-2-ylamino)-hexyl]-amide
• 英文别名: N-[6-[(4-aminoquinazolin-2-yl)amino]hexyl]naphthalene-1-sulfonamide
• 化学式: C₂₄H₂₇N₅O₂S
• 分子量: 449.6
• InChiKey: RAWXKZPWRXQRSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  118
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  N-(6-氨基己基)萘-1-磺酰胺盐酸盐 、 2-氯喹唑啉-4-胺 以 异戊醇 为溶剂， 反应 15.0h， 以yields naphthalene-1-sulfonic acid [6-(4-amino-quinazolin-2-ylamino)-hexyl]-amide as a white powder, melting at 98-101° C的产率得到Naphthalene-1-sulfonic acid [6-(4-amino-quinazolin-2-ylamino)-hexyl]-amide
  参考文献：
  名称：

  Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5)

  摘要：

  该发明提供了修改进食行为的方法，包括增加或减少食物摄入量，例如与治疗肥胖症、暴食症或厌食症有关。这些方法涉及给予选择性激动剂或拮抗剂或Y5受体的化合物。其中一种化合物具有以下结构：1此外，该发明提供了编码Y5受体的分离核酸分子、分离的Y5受体蛋白、包含编码Y5受体的分离核酸分子的载体、包含这种载体的细胞、针对Y5受体的抗体、用于检测编码Y5受体的核酸探针、互补于编码Y5受体的任何独特序列的反义寡核苷酸，以及表达正常或突变Y5受体DNA的非人类转基因动物。

  公开号：

  US20020103123A1

文献信息

• Methods of modifying feeding behavior using compounds with afinity for the human hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5)
  申请人：Synaptic Pharmaceutical Corporation

  公开号：US06645774B1

  公开（公告）日：2003-11-11

  This invention provides methods of modifying feeding behavior, including increasing or decreasing food consumption, e.g., in connection with treating obesity, bulimia or anorexia. These methods involve administration of compounds that are selective agonists or antagonists for the Y5 receptor. One such compound has the structure: In addition, this invention provides an isolated nucleic acid molecule encoding a Y5 receptor, an isolated Y5 receptor protein, vectors comprising an isolated nucleic acid molecule encoding a Y5 receptor, cells comprising such vectors, antibodies directed to the Y5 receptor, nucleic acid probes useful for detecting nucleic acid encoding Y5 receptors, antisense oligonucleotides complementary to any unique sequences of a nucleic acid molecule which encodes a Y5 receptor, and nonhuman transgenic animals which express DNA encoding a normal or a mutant Y5 receptor.

  这项发明提供了修改饮食行为的方法，包括增加或减少食物摄入量，例如与治疗肥胖症、暴食症或厌食症有关。这些方法涉及到给予选择性Y5受体激动剂或拮抗剂的化合物。其中一种化合物的结构如下：此外，该发明还提供了编码Y5受体的分离核酸分子、分离的Y5受体蛋白、包含编码Y5受体的分离核酸分子的载体、包含这种载体的细胞、针对Y5受体的抗体、用于检测编码Y5受体的核酸探针、与编码Y5受体的任何独特序列互补的反义寡核苷酸，以及表达正常或突变Y5受体的非人类转基因动物。
• Methods of screening and preparing a composition using DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5)
  申请人：Synaptic Pharmaceutical Corporation

  公开号：US06316203B1

  公开（公告）日：2001-11-13

  This invention provides methods of modifying feeding behavior, including increasing or decreasing food consumption, e.g., in connection with treating obesity, bulimia or anorexia. These methods involve administration of compounds are selective agonists or antagonists or the Y5 receptor. One such compound has the structure: In addition, this invention provides an isolated nucleic acid molecule encoding a Y5 receptor, an isolated Y5 receptor protein, vectors comprising an isolated nucleic acid molecule encoding a Y5 receptor, cells comprising such acid probes useful for detecting nucleic acid encoding Y5 receptors, antisense oligonucleotides complementary to any unique sequences of a nucleic acid molecule which encodes a Y5 receptor, and nonhuman transgenic animals which express DNA a normal or a mutant Y5 receptor.

  本发明提供了修改饮食行为的方法，包括增加或减少食物摄入量，例如与治疗肥胖症、暴食症或厌食症有关。这些方法涉及到给予选择性Y5受体的激动剂或拮抗剂化合物。其中一种化合物的结构如下：此外，本发明提供了编码Y5受体的分离核酸分子、分离的Y5受体蛋白、包含编码Y5受体的分离核酸分子的载体、含有这种核酸探针的细胞，用于检测编码Y5受体的核酸的反义寡核苷酸，以及表达正常或突变Y5受体的非人类转基因动物。
• DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor
  申请人：Synaptic Pharmaceutical Corporation

  公开号：US05968819A1

  公开（公告）日：1999-10-19

  This invention provides methods of modifying feeding behavior, including increasing or decreasing food consumption, e.g., in connection with treating obesity, bulimia or anorexia. These methods involve administration of compounds are selective agonists or antagonists or the Y5 receptor. One such compound has the structure: ##STR1## In addition, this invention provides an isolated nucleic acid molecule encoding a Y5 receptor, an isolated Y5 receptor protein, vectors comprising an isolated nucleic acid molecule encoding a Y5 receptor, cells comprising such vectors, antibodies directed to the Y5 receptor, nucleic acid probes useful for detecting nucleic acid encoding Y5 receptors, antisense oligonucleotides complementary to any unique sequences of a nucleic acid molecule which encodes a Y5 receptor, and nonhuman transgenic animals which express DNA a normal or a mutant Y5 receptor.

  本发明提供了修改饮食行为的方法，包括增加或减少食物摄入，例如与治疗肥胖症、暴食症或厌食症有关。这些方法涉及到给予选择性Y5受体的激动剂或拮抗剂的化合物。其中一种化合物具有以下结构：##STR1##此外，本发明提供了编码Y5受体的孤立核酸分子，孤立的Y5受体蛋白质，包含编码Y5受体的孤立核酸分子的载体，含有这种载体的细胞，针对Y5受体的抗体，用于检测编码Y5受体的核酸的核酸探针，与编码Y5受体的任何独特序列互补的反义寡核苷酸，以及表达正常或突变Y5受体的非人类转基因动物。
• Methods of modifying feeding behavior compounds useful in such methods
  申请人：Synaptic Pharmaceutical Corporation

  公开号：US05989920A1

  公开（公告）日：1999-11-23

  This invention provides methods of modifying feeding behavior, including increasing or decreasing food consumption, e.g., in connection with treating obesity, bulimia or anorexia. These methods involve administration of compounds that are selective agonists or antagonists for the Y5 receptor. One such compound has the structure: ##STR1## In addition, this invention provides an isolated nucleic acid molecule encoding a Y5 receptor, an isolated Y5 receptor protein, vectors comprising an isolated nucleic acid molecule encoding a Y5 receptor, cells comprising such vectors, antibodies directed to the Y5 receptor, nucleic acid probes useful for detecting nucleic acid encoding Y5 receptors, antisense oligonucleotides complementary to any unique sequences of a nucleic acid molecule which encodes a Y5 receptor, and nonhuman transgenic animals which express DNA encoding a normal or a mutant Y5 receptor.

  本发明提供了一种修改进食行为的方法，包括增加或减少食物摄入量，例如在治疗肥胖症、暴食症或厌食症方面。这些方法涉及到给予选择性Y5受体激动剂或拮抗剂的化合物。其中一种化合物的结构如下：##STR1## 此外，本发明还提供了编码Y5受体的分离核酸分子、分离的Y5受体蛋白、包含编码Y5受体的分离核酸分子的载体、含有这种载体的细胞、针对Y5受体的抗体、用于检测编码Y5受体的核酸探针、与编码Y5受体的任何独特序列互补的反义寡核苷酸，以及表达正常或突变Y5受体的非人类转基因动物。
• METHODS OF MODIFYING FEEDING BEHAVIOR, COMPOUNDS USEFUL IN SUCH METHODS, AND DNA ENCODING A HYPOTHALAMIC ATYPICAL NEUROPEPTIDE Y/PEPTIDE YY RECEPTOR (Y5)
  申请人：SYNAPTIC PHARMACEUTICAL CORPORATION

  公开号：EP1007073A1

  公开（公告）日：2000-06-14