6-methyl-2-piperazin-1-yl-7H-pyrrolo[3,4-d]pyrimidin-5-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 6-methyl-2-piperazin-1-yl-7H-pyrrolo[3,4-d]pyrimidin-5-one
• 化学式: C₁₁H₁₅N₅O
• 分子量: 233.27
• InChiKey: MLVNBIZLVSIUJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  61.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-methyl-2-piperazin-1-yl-7H-pyrrolo[3,4-d]pyrimidin-5-one 生成 6-methyl-2-piperazin-1-yl-7H-pyrrolo[3,4-d]pyrimidin-5-one;phosphoric acid
  参考文献：
  名称：

  AWAYA, AKIRA;NAKANO, TAKUO;KOBAYASHI, HISASHI;TAN, KEN E.;HORIKOMI, KAZUT+

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(4-benzylpiperazin-1-yl)-6-methyl-7H-pyrrolo[3,4-d]pyrimidin-5-one 生成 6-methyl-2-piperazin-1-yl-7H-pyrrolo[3,4-d]pyrimidin-5-one
  参考文献：
  名称：

  YOKOYAMA, KEIICHI;KATO, KOJI;KITAHARA, TAKUMI;OHNO, HIROYASU;NISHINA, TAK+

  摘要：

  DOI：

文献信息

• Quinazoline derivatives and antihypertensive preparations containing same as effective components
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0188094A2

  公开（公告）日：1986-07-23

  Disclosed herein is an antihypertensive preparation containing, as an active component, a novel quinazoline derivative represented by the following general formula or a saft thereof: wherein R100 means a hydrogen atom or methoxy group, R200 and R300 denote individually a hydrogen atom or lower alkoxy group, R400is a hydrogen atom or amino group, stands for 2 or 3, and Het is a specific hetero ring group.

  本发明公开了一种抗高血压制剂，其活性成分含有由以下通式代表的新型喹唑啉衍生物或其 翻版： 其中 R100 表示氢原子或甲氧基，R200 和 R300 分别表示氢原子或低级烷氧基，R400 是氢原子或氨基，代表 2 或 3，Het 是特定的杂环基团。
• Wound-healing agent
  申请人：MITSUI PHARMACEUTICALS, INC.

  公开号：EP0743066A2

  公开（公告）日：1996-11-20

  The present invention provides a method for the screening of a wound-healing agent, which comprises determining a substance to be active as a wound-healing agent on the basis of potentiation or modification of biological activities of a growth and/or differentiation factor, a growth hormone or a cytokine. This invention also provides a wound-healing agent, which comprises as an active ingredient a compound of the following formula (1) or formula (2).

  本发明提供了一种筛选伤口愈合剂的方法，该方法包括根据生长和/或分化因子、生长激素或细胞因子的生物活性的增强或改变来确定一种物质作为伤口愈合剂的活性。本发明还提供了一种伤口愈合剂，其活性成分包括下式（1）或式（2）的化合物。
• Combination therapy to improve brain function or promote neurogenesis for treating neurodegenerative conditions
  申请人：UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

  公开号：US10751340B2

  公开（公告）日：2020-08-25

  Disclosed herein are methods and materials for improving brain function and/or promoting neurogenesis m a patient suffering from impaired brain function. Specifically exemplified herein ls the co-administration of phenserine and NBI-18. A method of treating a neurodegenerative disease in a patient in need thereof, said method comprising co-administering to the patient phenserine, or pharmaceutically acceptable salt thereof, and NBI-18, or pharmaceutically acceptable salt thereof, in respective amounts and frequency such that they work together to improve brain function or induce neurogenesis in the patient.

  本文公开了用于改善脑功能和/或促进脑功能受损患者神经发生的方法和材料。在此具体举例说明的是联合给药芬丝林和 NBI-18。一种治疗有需要的患者的神经退行性疾病的方法，所述方法包括以各自的用量和频率向患者联合给药表皮生长因子或其药学上可接受的盐和NBI-18或其药学上可接受的盐，使它们共同作用以改善患者的脑功能或诱导神经发生。
• 2-PIPERAZINOPYRIMIDINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0192783B1

  公开（公告）日：1991-04-17
• AWAYA, AKIRA;NAKANO, TAKUO;KOBAYASHI, HISASHI;TAN, KEN E.;HORIKOMI, KAZUT+
  作者：AWAYA, AKIRA、NAKANO, TAKUO、KOBAYASHI, HISASHI、TAN, KEN E.、HORIKOMI, KAZUT+

  DOI：——

  日期：——