2-(hydroxyamino)-1,4-naphthoquinone | 53130-67-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(hydroxyamino)-1,4-naphthoquinone
• 英文别名: 2-(hydroxyamino)naphthalene-1,4-dione
• CAS: 53130-67-9
• 化学式: C₁₀H₇NO₃
• 分子量: 189.17
• InChiKey: QEEGGECMANPQAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(1,4-dihydroxy-[2]naphthyl)-decan-1-one 在 盐酸羟胺 、 sodium acetate 作用下， 以 甲醇 为溶剂， 反应 20.0h， 以63%的产率得到2-(hydroxyamino)-1,4-naphthoquinone
  参考文献：
  名称：

  关于 2-烷酰基萘氢醌与羟胺的反应：获得细胞毒性 2-(羟基氨基)-1,4-萘醌及其 3-(羟基亚氨基)烷基类似物

  摘要：

  肟以其抗炎、抗菌、抗氧化和抗癌活性而闻名。通常，将具有生物活性的羰基化合物修饰成肟会导致活性增加。本研究报告了 2-烷酰基萘氢醌在空气条件下对羟胺的反应性。结果表明，根据氢醌的结构，反应通过两种不同的化学途径进行，生成 2-(羟基氨基)-1,4-萘醌及其 C-3(羟基亚氨基)烷基衍生物。讨论了空气氧化下醌类化合物的形成和半胺中间体的 CC 裂解反应。在一组癌细胞上对取代的 1,4-萘醌进行体外筛选显示出中等的细胞毒活性。化合物19, 2-(hydroxyamino)-1,4-naphthoquinone 因其对前列腺癌细胞的抗癌效力而脱颖而出，如最低的 IC 50值 (8.08  μM ) 和最佳的选择性指数 (3.90) 所示。

  DOI：

  10.1155/2022/7664037

文献信息

• COMPOSITION FOR INHIBITING OR PREVENTING THE FORMATION OF A BIOFILM
  申请人：Oystershell NV

  公开号：EP1796656A2

  公开（公告）日：2007-06-20
• Composition for Inhibiting or Preventing the Formation of a Biofilm
  申请人：Rossel Bart

  公开号：US20070258913A1

  公开（公告）日：2007-11-08

  Compounds for inhibiting and/or preventing the formation of a biofilm are disclosed. The compounds are an anthraquinone and/or a naphtoquinone, stereoisomeric forms, racemic mixtures, metabolites, esters or salts thereof, or mixtures thereof, and/or at least one plant extract including the compound or active fraction thereof. Compositions containing the compounds such as oral health products and methods of using the products in a method to prevent or inhibit biofilm formation are also disclosed. Preferred compositions include emodin and/or plant extracts from Rheum sp.
• Multi-stage stem cell carcinogenesis
  申请人：Krtolica Ana

  公开号：US20100162416A1

  公开（公告）日：2010-06-24

  The present invention relates to a system of multi-stage stem cell carcinogenesis and a method of generating such multi-stage stem cell carcinogenesis system. Various stages of cancer stem cells can be generated from normal stem cells via mutagenesis. The system of the present invention enables monitoring changes in the ability of cells to transition from one stage of carcinogenesis to another and to identify genetic pathways and molecules that influence carcinogenesis. The present invention also enables a high-throughput and nonbiased screening for targets that preferentially affect cancer stem cells relative to non-cancer stem cells or their derivatives during stem cell carcinogenesis, thus is useful in developing anti-cancer therapeutics.
• US7691418B2
  申请人：——

  公开号：US7691418B2

  公开（公告）日：2010-04-06
• [EN] COMPOSITION FOR INHIBITING OR PREVENTING THE FORMATION OF A BIOFILM<br/>[FR] COMPOSITION PERMETTANT DE BLOQUER OU D'EMPECHER LA FORMATION D'UN FILM BIOLOGIQUE
  申请人：OYSTERSHELL NV

  公开号：WO2006029893A2

  公开（公告）日：2006-03-23

  The present invention provides the use of a compound selected from the group comprising an anthraquinone and a naphtoquinone, stereoisomeric forms, racemic mixtures, metabolites, esters or salts thereof, or mixtures thereof, and/or of at least one plant extract or active fraction thereof comprising said compound for preventing and/or inhibiting biofilm formation. The present invention further relates to compositions for preventing and/or inhibiting the formation of a biofilm, oral health products and a method for preventing and/or inhibiting biofilm formation.