N-[1-(4-bromophenyl)ethylidene]-2-(naphthalen-2-yloxy)propionic acid hydrazide | 507445-07-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[1-(4-bromophenyl)ethylidene]-2-(naphthalen-2-yloxy)propionic acid hydrazide
• 英文别名: N-[1-(4-bromophenyl)ethylideneamino]-2-naphthalen-2-yloxypropanamide
• CAS: 507445-07-0
• 化学式: C₂₁H₁₉BrN₂O₂
• 分子量: 411.298
• InChiKey: GPBSAHMUBFEMIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(2-萘氧基)丙酰肼 、 4-溴苯乙酮 以 乙醇 为溶剂， 反应 3.0h， 以67%的产率得到N-[1-(4-bromophenyl)ethylidene]-2-(naphthalen-2-yloxy)propionic acid hydrazide
  参考文献：
  名称：

  Design, synthesis and hypolipidemic activity of novel 2-(naphthalen-2-yloxy)propionic acid derivatives as desmethyl fibrate analogs

  摘要：

  A series of 2-(naphthalen-2-yloxy)propionic acid derivatives were prepared. The hypolipidemic activity of the new compounds as well as the intermediate acid 2 was evaluated in the high cholesterol diet (HCD) fed hyperlipidemic rat model. Interestingly, the 5-alkylated mercaptotriazole 8b and the 1,3,4-oxadiazole 9 produced striking reduction of serum levels of total cholesterol (TC), triglycerides (TGs) and low-density lipoproteins (LDLs) and elevation of serum high-density lipoproteins (HDLs) being more active than the reference gemfibrozil. In addition, the 1,2,4-triazole 7a, the hydroxypyrazoline 10 and the pyrazolone derivative 11 exhibited good hypolipidemic activity on different lipid parameters. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.04.026

文献信息

• Design, synthesis and hypolipidemic activity of novel 2-(naphthalen-2-yloxy)propionic acid derivatives as desmethyl fibrate analogs
  作者：Gamal A. Idrees、Omar M. Aly、Gamal El-Din A.A. Abuo-Rahma、M.F. Radwan

  DOI：10.1016/j.ejmech.2009.04.026

  日期：2009.10

  A series of 2-(naphthalen-2-yloxy)propionic acid derivatives were prepared. The hypolipidemic activity of the new compounds as well as the intermediate acid 2 was evaluated in the high cholesterol diet (HCD) fed hyperlipidemic rat model. Interestingly, the 5-alkylated mercaptotriazole 8b and the 1,3,4-oxadiazole 9 produced striking reduction of serum levels of total cholesterol (TC), triglycerides (TGs) and low-density lipoproteins (LDLs) and elevation of serum high-density lipoproteins (HDLs) being more active than the reference gemfibrozil. In addition, the 1,2,4-triazole 7a, the hydroxypyrazoline 10 and the pyrazolone derivative 11 exhibited good hypolipidemic activity on different lipid parameters. (C) 2009 Elsevier Masson SAS. All rights reserved.