乳化剂OS（MS-1） | 58265-74-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 中文名称: 乳化剂OS（MS-1）
• 英文名称: 3-Hydroxy-4,5-bis(hydroxymethyl)-2-(3-methylbut-2-en-1-yl)phenyl 2,4-dihydroxy-6-methylbenzoate
• 英文别名: [3-hydroxy-4,5-bis(hydroxymethyl)-2-(3-methylbut-2-enyl)phenyl] 2,4-dihydroxy-6-methylbenzoate
• CAS: 58265-74-0
• 化学式: C₂₁H₂₄O₇
• 分子量: 388.4
• InChiKey: WTZUCTQSBSDSRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  127
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-(1-((5-chlorobenzo[b]thiophen-3-yl)methyl)-1H-indol-3-yl)acetonitrile 、 、 sodium hexamethyldisilazane 、 碘甲烷 、 2-(1-((5-chlorobenzo[b]thiophen-3-yl)methyl)-1H-indol-3-yl)-2-methylpropanenitrile 、 叠氮基三甲基硅烷 、 、 乳化剂OS（MS-1） 在 盐酸 、 Brine 、 magnesium sulfate 、 hexanes DCM 、 2-(1-((5-chlorobenzo[b]thiophen-3-yl)methyl)-1H-indol-3-yl)propanenitrile 、 2-(1-((5-chlorobenzo[b]thiophen-3-yl)methyl)-1H-indol-3-yl)-2-methylpropanenitrile 、 silica gel 、 ethyl acetate dichloromethane 、 methanol-dichloromethane 作用下， 以 四氢呋喃 、 乙酸乙酯 为溶剂， 反应 30.33h， 以3-(2-(1H-tetrazol-5-yl)propan-2-yl)-1-((5-chlorobenzo[b]thiophen-3-yl)methyl)-1H-indole (3 mg, 2.87% yield) was also isolated by PLC as a white solid from band at Rf 0.4 (NMR-3, MS-3)的产率得到3-(2-(1H-tetrazol-5-yl)propan-2-yl)-1-((5-chlorobenzo[b]thiophen-3-yl)methyl)-1H-indole
  参考文献：
  名称：

  NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION

  摘要：

  本实施例提供通式I的化合物，以及包括制剂（包括制药制剂）的组合物，其中包括一种主体化合物。本实施例进一步提供治疗方法，包括治疗丙型肝炎病毒感染的方法，该方法通常涉及向需要的个体施用主体化合物或组合物的有效量。

  公开号：

  US20090047246A1

文献信息

• Environment-friendly high-temperature resistant water-based drilling fluid plugging anti-sloughing agent, preparation method thereof and the water-based drilling fluid
  申请人：CHINA UNIVERSITY OF PETROLEUM (EAST CHINA)

  公开号：US11072738B2

  公开（公告）日：2021-07-27

  The present disclosure provides a preparation method of an environment-friendly high-temperature resistant water-based drilling fluid plugging anti-sloughing agent, the preparation method comprises the following steps: mixing and emulsifying a styrene monomer, an acrylic monomer and an emulsifier MS-1 aqueous solution to prepare a pre-polymerization emulsion; dispersing hydrophilic monomer, cationic monomer and an emulsifier MS-1 in water, adjusting the pH to be within a range of 6.5-8.5, then adding mixed monomers of the styrene monomer and acrylic monomer to blend and emulsify to prepare a post-polymerization emulsion; adding a first cross-linking agent and a first initiator into the pre-polymerization emulsion, uniformly dispersing the mixture and carrying out reaction; subsequently dropwise adding the post-polymerization emulsion, adding a second cross-linking agent and a second initiator, uniformly dispersing the mixture and then continuously carrying out reaction, drying and crushing the reaction product to prepare the plugging anti-sloughing agent.

  本发明公开了一种环保型耐高温水基钻井液堵漏防滑剂的制备方法，该制备方法包括以下步骤：将苯乙烯单体、丙烯酸单体和乳化剂MS-1水溶液混合乳化，制备预聚合乳液；将亲水单体、阳离子单体和乳化剂MS-1分散于水中，调节pH值在6.5-8.5，然后加入苯乙烯单体和丙烯酸单体的混合单体进行混合乳化，制备后聚合乳液；在前聚合乳液中加入第一交联剂和第一引发剂，均匀分散混合物并进行反应；随后滴加后聚合乳液，加入第二交联剂和第二引发剂，均匀分散混合物，然后连续进行反应，干燥并粉碎反应产物，制备堵漏防脱落剂。
• ENVIRONMENT-FRIENDLY HIGH-TEMPERATURE RESISTANT WATER-BASED DRILLING FLUID PLUGGING ANTI-SLOUGHING AGENT, PREPARATION METHOD THEREOF AND THE WATER-BASED DRILLING FLUID
  申请人：CHINA UNIVERSITY OF PETROLEUM (EAST CHINA)

  公开号：US20210189216A1

  公开（公告）日：2021-06-24

  The present disclosure provides a preparation method of an environment-friendly high-temperature resistant water-based drilling fluid plugging anti-sloughing agent, the preparation method comprises the following steps: mixing and emulsifying a styrene monomer, an acrylic monomer and an emulsifier MS-1 aqueous solution to prepare a pre-polymerization emulsion; dispersing hydrophilic monomer, cationic monomer and an emulsifier MS-1 in water, adjusting the pH to be within a range of 6.5-8.5, then adding mixed monomers of the styrene monomer and acrylic monomer to blend and emulsify to prepare a post-polymerization emulsion; adding a first cross-linking agent and a first initiator into the pre-polymerization emulsion, uniformly dispersing the mixture and carrying out reaction; subsequently dropwise adding the post-polymerization emulsion, adding a second cross-linking agent and a second initiator, uniformly dispersing the mixture and then continuously carrying out reaction, drying and crushing the reaction product to prepare the plugging anti-sloughing agent.
• NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION
  申请人：Beigelman Leonid

  公开号：US20090047246A1

  公开（公告）日：2009-02-19

  The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

  本实施例提供通式I的化合物，以及包括制剂（包括制药制剂）的组合物，其中包括一种主体化合物。本实施例进一步提供治疗方法，包括治疗丙型肝炎病毒感染的方法，该方法通常涉及向需要的个体施用主体化合物或组合物的有效量。