8-chloro-2-(2-(diethylamino)ethyl)-5-hydroxymethyl-2H(1) benzothiopyrano[4,3,2-cd]indazole | 24167-40-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫色烯
• 英文名称: 8-chloro-2-(2-(diethylamino)ethyl)-5-hydroxymethyl-2H(1) benzothiopyrano[4,3,2-cd]indazole
• 英文别名: 8-Chloro-2-(2-(diethylamino)ethyl)-2H-(1)benzothiopyrano(4,3,2-cd)indazole-5-methanol；[5-chloro-14-[2-(diethylamino)ethyl]-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-10-yl]methanol
• CAS: 24167-40-6
• 化学式: C₂₀H₂₂ClN₃OS
• 分子量: 387.933
• InChiKey: SRBMBMSGNPWLNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  66.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  8-chloro-2-(2-(diethylamino)ethyl)-5-hydroxymethyl-2H(1) benzothiopyrano[4,3,2-cd]indazole 在 potassium acetate 、 间氯过氧苯甲酸 作用下， 以 乙醇 为溶剂， 生成 8-chloro-2-(2-(diethylamino)ethyl)-5-hydroxymethyl-2H(1) benzothiopyrano[4,3,2-cd]indazole N-oxide
  参考文献：
  名称：

  Benzo and benzothiopyranoindazole N-oxides

  摘要：

  本文介绍了2H(1)苯并噻吩并[4,3,2-cd]吲哚N-氧化物，2H(1)苯并噻吩并[4,3,2-cd]吲哚N-氧化物及其酸加成盐。这些化合物可以通过将相应的胺与能够形成N-氧化物衍生物的氧化剂进行氧化反应来制备。这些化合物是治疗血吸虫感染的寄生虫灭活剂。

  公开号：

  US03963740A1

文献信息

• 7-phenyl-7-(3-pyridyl)-6-heptenoic acid or derivatives thereof which
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US04727078A1

  公开（公告）日：1988-02-23

  Novel compound of the formula: ##STR1## wherein R.sup.1 is pyridyl group, R.sup.2 is a phenyl group, a thienyl group, a furyl group, a naphthyl group, a benzothienyl group or pyridyl group, which may optionally have a lower alkoxy group, a lower alkyl group, a halogen atom, trifluoromethyl group, a lower alkenyl group or methylenedioxy group, R.sup.3 is hydrogen atom or a lower alkyl group, and n is an integer of 0 to 6, Y is sulphur atom, methylene group or a group of the formula: ##STR2## wherein R.sup.4 is hydrogen atom or acetyl group, and m is 0 or 1, and their pharmaceutically acceptable salts have an inhibitory action on bio-synthesis of thromboxane A.sub.2 (TXA.sub.2) and an effect of accelerating the productivility of prostaglandin I.sub.2 (PGI.sub.2), and can be used for mammals to the prophylaxis or therapy of thrombosis caused by platelet aggregation or ischemic diseases caused by vasospasms in cardiac, cerebral and peripheral circulatory system (e.g. cardiac infarction, apoplexy, infarct of blood vessels in kidney, lung and other organs, pectic ulcer, etc.).

  化合物的新型配方：##STR1## 其中，R.sup.1是吡啶基，R.sup.2是苯基，噻吩基，呋喃基，萘基，苯并噻吩基或吡啶基，可选地带有较低的烷氧基，较低的烷基，卤素原子，三氟甲基基团，较低的烯基或亚甲二氧基基团，R.sup.3是氢原子或较低的烷基，n是0到6的整数，Y是硫原子，亚甲基基团或公式的基团：##STR2## 其中，R.sup.4是氢原子或乙酰基，m是0或1，它们的药学上可接受的盐具有抑制血栓素A.sub.2（TXA.sub.2）的生物合成作用和加速前列腺素I.sub.2（PGI.sub.2）的产生能力，可用于哺乳动物的预防或治疗由血小板聚集引起的血栓形成或由心脏，脑和周围循环系统的血管痉挛引起的缺血性疾病（例如心肌梗塞，中风，肾脏，肺和其他器官的血管梗塞，消化性溃疡等）。
• Certain pyridyl alkenoic acid derivatives which inhibit the action of
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US04760068A1

  公开（公告）日：1988-07-26

  Novel compound of the formula: ##STR1## wherein R.sup.1 is pyridyl group, R.sup.2 is a phenyl group, a thienyl group, a furyl group, a naphthyl group, a benzothienyl group or pyridyl group, which may optionally have a lower alkoxy group, a lower alkyl group, a halogen atom, trifluoromethyl group, a lower alkenyl group or methylenedioxy group, R.sup.3 is hydrogen atom or a lower alkyl group, and n is an integer of 0 to 6, Y is sulphur atom, methylene group or a group of the formula: ##STR2## wherein R.sup.4 is hydrogen atom or acetyl group, and m is 0 or 1, and their pharmaceutically acceptable salts having an inhibitory action on bio-synthesis of thromboxane A.sub.2 (TXA.sub.2) and an effect of accelerating the productivility of prostaglandin I.sub.2 (PGI.sub.2), and can be used for mammals to the prophylaxis or therapy of thrombosis caused by platelet aggregation or ischemic diseases caused by vasospasms in cardiac, cerebral and peripheral circulatory system (e.g. cardiac infarction, apoplexy, infarct of blood vessels in kidney, lung and other organs, pectic ulcer, etc.).

  化合物的结构式为：##STR1## 其中R.sup.1是吡啶基，R.sup.2是苯基、噻吩基、呋喃基、萘基、苯并噻吩基或吡啶基，可以选择性地具有较低的烷氧基、较低的烷基、卤素原子、三氟甲基基团、较低的烯基或亚甲氧基基团，R.sup.3是氢原子或较低的烷基，n为0到6的整数，Y是硫原子、亚甲基基团或式子：##STR2## 其中R.sup.4是氢原子或乙酰基团，m为0或1，以及其药学上可接受的盐，具有抑制血栓素A.sub.2（TXA.sub.2）的生物合成和加速前列腺素I.sub.2（PGI.sub.2）的产生的作用，并可用于哺乳动物的预防或治疗由血小板聚集引起的血栓形成或由心脏、脑和周围循环系统中的血管痉挛引起的缺血性疾病（例如心肌梗塞、中风、肾脏、肺和其他器官的血管梗塞、消化性溃疡等）。
• 2-(2,4,6-trimethyl phenyl)cyclopentane-1,3-dione derivatives
  申请人：Bayer Aktiengesellschaft

  公开号：US05808135A1

  公开（公告）日：1998-09-15

  The present invention relates to novel substituted bicyclic 2-mesityl-cyclopentane-1,3-dione derivatives of the formula (I) ##STR1## in which A and Q together represent alkanediyl or alkenediyl, which is in each case optionally substituted by halogen, hydroxyl, mercapto or in each case optionally substituted alkyl, alkoxy, alkylthio, cycloalkyl, benzyloxy or aryl, and which furthermore optionally contains one of the following groups ##STR2## or is bridged by an alkanediyl group and B, B' and G have the meaning given in the description, process for their preparation and their use as agents for controlling pests, and herbicides.

  本发明涉及式(I)的新型取代双环2-二甲苯基环戊烷-1,3-二酮衍生物，其中A和Q共同表示脂肪二烯基或烯丙基，分别可以选择地被卤素、羟基、巯基或选择性取代的烷基、烷氧基、烷硫基、环烷基、苄氧基或芳基取代，而且还可以包含以下一种基团之一##STR2## 或由脂肪二烯基桥接，而B、B'和G的含义如描述中所给出的，以及其制备过程和作为控制害虫和除草剂的药剂的用途。
• BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS
  申请人：SANOFI-SYNTHELABO

  公开号：EP0812192B1

  公开（公告）日：2002-11-06
• US3963740A
  申请人：——

  公开号：US3963740A

  公开（公告）日：1976-06-15