1,3-bis-(4-pyrimidin-2-yl-piperazino)-propane | 102165-99-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,3-bis-(4-pyrimidin-2-yl-piperazino)-propane
• 英文别名: 1,3-Bis-(4-pyrimidin-2-yl-piperazino)-propan
• CAS: 102165-99-1
• 化学式: C₁₉H₂₈N₈
• 分子量: 368.485
• InChiKey: KHZRNARVFYYQCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  27.0
• 可旋转键数：
  6.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  64.52
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  1-(2-嘧啶基)哌嗪 、 1,3-二溴丙烷 生成 1,3-bis-(4-pyrimidin-2-yl-piperazino)-propane
  参考文献：
  名称：

  Substituted alkylenedipiperazines

  摘要：

  公开号：

  US02837522A1

文献信息

• 2-{4-[3-(4-Aryl/heteroaryl-1-piperazinyl)propoxy]phenyl}-2H-benzotriazoles and their N-oxides as ligands for serotonin and dopamine receptors
  作者：Anna Sparatore、Mara Goegan、Alfredo Cagnotto、Fabio Sparatore

  DOI：10.1016/s0014-827x(99)00046-4

  日期：1999.6

  A small set of 2-4-[3-(4-aryl/heteroaryl-piperazinyl)propoxy]phenyl}-2H-benzotriazoles and corresponding N-oxides were prepared. The synthesized compounds were able to bind on some serotonin (5-HT1A, 5-HT2A) and dopamine (D-2, D-3) receptors, while displaying poor or no affinity for 5-HT1B, 5-NT2C, 5-HT3, and 5-HT4 subtypes. The strong contribution of the N-oxide function for the binding on 5-HT1A, D-2 and D-3 receptors is noteworthy. For 2-4-[3-[4-(2-methoxyphenyl)-1-piperazinyl]propoxy]phenyl}-2H-benzotriazol-1-oxide (4b), the binding constants (K-i) were 11.9 (5-HT1A) and 10.5 nM (D-3). In a general pharmacological screening, the 2-4-[3-(4-phenyl-1-piperazinyl)propoxy]phenyl}-2H-benzotriazole (3a) exhibited only very weak activities, with the exception of protecting mice from cyanide-induced hypoxia. (C) 1999 Elsevier Science S.A. All rights reserved.