2-Benzyloxy-5-piperidin-1-yl-benzaldehyde | 796047-14-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-Benzyloxy-5-piperidin-1-yl-benzaldehyde
• CAS: 796047-14-8
• 化学式: C₁₉H₂₁NO₂
• 分子量: 295.381
• InChiKey: RCGWFURIDZUXCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.07
• 重原子数：
  22.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  29.54
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  罗丹宁 、 2-Benzyloxy-5-piperidin-1-yl-benzaldehyde 在 哌啶乙酸盐 作用下， 以 甲苯 为溶剂， 生成 5-[1-(2-Benzyloxy-5-piperidin-1-yl-phenyl)-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one
  参考文献：
  名称：

  Synthesis and biological evaluation of thiazolidine-2,4-dione and 2,4-thione derivatives as inhibitors of translation initiation

  摘要：

  In an effort to generate novel translation initiation inhibitors for cancer therapy, a series of 2'-benzyloxy-5'-substituted-5-benzylidene-thiazolidine-2,4-thione and dione derivatives was synthesized and evaluated for activity in translation initiation specific assays. Several candidates of the 5-benzylidene-thiazolidine-2,4-diones (3c, 3d, and 3f) and -thiones (2b, 2e, and 2j), inhibit cell growth with low muM GI(50) mediated by inhibition of translation initiation, which involves partial depletion of intracellular Ca2+ stores and strong phosphorylation of eIF2alpha. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.08.017
• 作为产物：
  描述：

  2-(2-Benzyloxy-5-iodo-phenyl)-[1,3]dioxolane 在 potassium phosphate 、 copper(l) iodide 、 4-甲基苯磺酸吡啶 、 乙二醇 作用下， 以 异丙醇 、 丙酮 为溶剂， 生成 2-Benzyloxy-5-piperidin-1-yl-benzaldehyde
  参考文献：
  名称：

  Synthesis and biological evaluation of thiazolidine-2,4-dione and 2,4-thione derivatives as inhibitors of translation initiation

  摘要：

  In an effort to generate novel translation initiation inhibitors for cancer therapy, a series of 2'-benzyloxy-5'-substituted-5-benzylidene-thiazolidine-2,4-thione and dione derivatives was synthesized and evaluated for activity in translation initiation specific assays. Several candidates of the 5-benzylidene-thiazolidine-2,4-diones (3c, 3d, and 3f) and -thiones (2b, 2e, and 2j), inhibit cell growth with low muM GI(50) mediated by inhibition of translation initiation, which involves partial depletion of intracellular Ca2+ stores and strong phosphorylation of eIF2alpha. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.08.017