adenosine 5'-hexadecylphosphate | 68942-02-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: adenosine 5'-hexadecylphosphate
• 英文别名: [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hexadecyl hydrogen phosphate
• CAS: 68942-02-9
• 化学式: C₂₆H₄₆N₅O₇P
• 分子量: 571.654
• InChiKey: XNBFNPXGEIQVBJ-HUBRGWSESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  39
• 可旋转键数：
  20
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  175
• 氢给体数：
  4
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  Phosphoric acid (3aR,4R,6R,6aR)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester hexadecyl ester 在 溶剂黄146 作用下， 反应 2.0h， 以51%的产率得到adenosine 5'-hexadecylphosphate
  参考文献：
  名称：

  Synthesis and cytostatical evaluation of cytidine- and adenosine-5′-hexadecylphosphate and their phosphonate analogs

  摘要：

  Four phospholipid conjugates containing the non-cytotoxic nucleosides cytidine and adenosine were prepared by condensation reactions, and their cytotoxic activity was tested in vitro against the human immortalized mammary epithelial cell H184 A(1)N(4), the human mammary tumor cells MaTu and MCF7 and the B lymphoblast cell line Daudi. The synthesized compounds showed considerable activity towards H184 A(1)N(4), MaTu and Daudi cells, but they were not effective against MCF7 cells. The phosphorus moiety-either monophosphate or monophosphonate-does not influence the effectiveness of the phospholipid derivatives in the case of the solid tumor cell lines and H184 A(1)N(4). The leukemic Daudi cell line is strongly sensitive towards the different types of ester as well as to the type of the nucleoside component. Adenosine-5'-hexadecylphosphate proved to be the most potent compound among the substances prepared (IC50: 9.0 mu mol). (C) 1997 Elsevier Science Ireland Ltd.

  DOI：

  10.1016/s0009-3084(97)00074-1

文献信息

• COMPOSITIONS FOR THE ELIMINATION OF SENESCENT CELLS
  申请人：Universität für Bodenkultur Wien

  公开号：EP3643305A1

  公开（公告）日：2020-04-29

  The invention relates to a composition comprising one or more inhibitors capable of inhibiting at least two of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and lipoxygenase for use in selectively eliminating senescent cells. The invention further relates to an in vitro method of identifying senescent cells in a subject and to a method of identifying candidate compounds for the selective elimination of senescent cells.

  本发明涉及一种组合物，该组合物包含一种或多种抑制剂，能够抑制环氧合酶-1（COX-1）、环氧合酶-2（COX-2）和脂氧合酶中的至少两种，用于选择性地消除衰老细胞。本发明还涉及一种鉴定受试者衰老细胞的体外方法，以及一种鉴定用于选择性消除衰老细胞的候选化合物的方法。
• PRODUCTION OF BIODIESEL BY YEAST FROM LIGNOCELLULOSE AND GLYCEROL
  申请人：Technical University of Denmark

  公开号：EP2582798A1

  公开（公告）日：2013-04-24
• US8999683B2
  申请人：——

  公开号：US8999683B2

  公开（公告）日：2015-04-07
• [EN] PRODUCTION OF BIODIESEL BY YEAST FROM LIGNOCELLULOSE AND GLYCEROL<br/>[FR] PRODUCTION DE BIODIESEL PAR UNE LEVURE À PARTIR DE LIGNOCELLULOSE ET DE GLYCÉROL
  申请人：TECHNICAL UNVIERSITY OF DENMARK

  公开号：WO2011157848A1

  公开（公告）日：2011-12-22

  The invention is directed to a genetically modified microorganism for the extracellular production of free fatty acids and esters thereof, wherein said microorganism is characterised by a modified lipid biosynthesis metabolic pathway: for example reduced fatty acyl-coA synthetase activity that enables the microorganism to overproduce and secrete of esters of fatty acids (Biodiesel) into the surrounding medium, using one or more of: glucose, starch, lignocellulose and a glycerol-based substrate, as a carbon source. The invention further provides a method for the extracellular production of free fatty acids and esters thereof, comprising the use of said genetically modified organism, and a growth medium adapted for said method.