tert-butyl-[5-[[(2S,3S,4R)-1-[tert-butyl(diphenyl)silyl]oxy-2,4-dimethylhex-5-en-3-yl]oxy-dimethylsilyl]oxyhept-6-enoxy]-diphenylsilane | 330157-44-3

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: tert-butyl-[5-[[(2S,3S,4R)-1-[tert-butyl(diphenyl)silyl]oxy-2,4-dimethylhex-5-en-3-yl]oxy-dimethylsilyl]oxyhept-6-enoxy]-diphenylsilane
• CAS: 330157-44-3
• 化学式: C₄₉H₇₀O₄Si₃
• 分子量: 807.349
• InChiKey: SXBBTTVXDDXGKU-YOLSILBLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.43
• 重原子数：
  56
• 可旋转键数：
  23
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl-[5-[[(2S,3S,4R)-1-[tert-butyl(diphenyl)silyl]oxy-2,4-dimethylhex-5-en-3-yl]oxy-dimethylsilyl]oxyhept-6-enoxy]-diphenylsilane 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 作用下， 以 苯 为溶剂， 反应 48.0h， 生成 (Z)-(4S,5R,8R)-8-[4-(tert-Butyl-diphenyl-silanyloxy)-butyl]-4-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-5,8-dihydro-4H-[1,3,2]dioxasilocine 、 (Z)-(4S,5R,8S)-8-[4-(tert-Butyl-diphenyl-silanyloxy)-butyl]-4-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-5,8-dihydro-4H-[1,3,2]dioxasilocine
  参考文献：
  名称：

  Formation of dissymmetric eight-membered silalketals by ring-closing metathesis and their conversion to spiroketals

  摘要：

  Eight-membered unsymmetrical silalketals are formed by RCM of mixed allyl/homoallyl silalketals. They are crucial intermediates in a short synthetic sequence to spiroketals illustrated in this paper by the synthesis of the C-28-C-38 portion of okadaic acid. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)01929-8
• 作为产物：
  描述：

  (2S,3S,4R)-1-(tert-butyldiphenylsilyloxy)-2,4-dimethyl-hex-5-en-3-ol 在 咪唑 、 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 16.17h， 生成 tert-butyl-[5-[[(2S,3S,4R)-1-[tert-butyl(diphenyl)silyl]oxy-2,4-dimethylhex-5-en-3-yl]oxy-dimethylsilyl]oxyhept-6-enoxy]-diphenylsilane
  参考文献：
  名称：

  Formation of dissymmetric eight-membered silalketals by ring-closing metathesis and their conversion to spiroketals

  摘要：

  Eight-membered unsymmetrical silalketals are formed by RCM of mixed allyl/homoallyl silalketals. They are crucial intermediates in a short synthetic sequence to spiroketals illustrated in this paper by the synthesis of the C-28-C-38 portion of okadaic acid. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)01929-8

文献信息

• Formation of dissymmetric eight-membered silalketals by ring-closing metathesis and their conversion to spiroketals
  作者：Jean-Guy Boiteau、Pierre Van de Weghe、Jacques Eustache

  DOI：10.1016/s0040-4039(00)01929-8

  日期：2001.1

  Eight-membered unsymmetrical silalketals are formed by RCM of mixed allyl/homoallyl silalketals. They are crucial intermediates in a short synthetic sequence to spiroketals illustrated in this paper by the synthesis of the C-28-C-38 portion of okadaic acid. (C) 2000 Elsevier Science Ltd. All rights reserved.