Tert-butyl 5-formyl-4-oxo-2-phenylpiperidine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Tert-butyl 5-formyl-4-oxo-2-phenylpiperidine-1-carboxylate
• 英文别名: tert-butyl 5-formyl-4-oxo-2-phenylpiperidine-1-carboxylate
• 化学式: C₁₇H₂₁NO₄
• 分子量: 303.358
• InChiKey: OOMGEQUTYRFIDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  63.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Tert-butyl 5-formyl-4-oxo-2-phenylpiperidine-1-carboxylate 在 一水合肼 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and Efficacious γ-Secretase Inhibitors

  摘要：

  Discovery of a series of pyrazolopiperidine sulfonamide based gamma-secretase inhibitors and its SAR evolution is described. Significant increases in APP potency on the pyrazolopiperidine scaffold over the original N-bicyclic sulfonamide scaffold were achieved and this potency increase translated in an improved in vivo efficacy. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.02.039
• 作为产物：
  描述：

  1-叔丁氧羰基-2-苯基-4-哌啶酮 、 甲酸乙酯 在 sodium hydride 作用下， 以 甲醇 、 苯 为溶剂， 生成 Tert-butyl 5-formyl-4-oxo-2-phenylpiperidine-1-carboxylate
  参考文献：
  名称：

  Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and Efficacious γ-Secretase Inhibitors

  摘要：

  Discovery of a series of pyrazolopiperidine sulfonamide based gamma-secretase inhibitors and its SAR evolution is described. Significant increases in APP potency on the pyrazolopiperidine scaffold over the original N-bicyclic sulfonamide scaffold were achieved and this potency increase translated in an improved in vivo efficacy. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.02.039

文献信息

• Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and Efficacious γ-Secretase Inhibitors
  作者：Xiaocong M. Ye、Andrei W. Konradi、Jenifer Smith、Ying-Zi Xu、Darren Dressen、Albert W. Garofalo、Jennifer Marugg、Hing L. Sham、Anh P. Truong、Jacek Jagodzinski、Michael Pleiss、Hongbin Zhang、Erich Goldbach、John-Michael Sauer、Elizabeth Brigham、Michael Bova、Guriqbal S. Basi

  DOI：10.1016/j.bmcl.2010.02.039

  日期：2010.4

  Discovery of a series of pyrazolopiperidine sulfonamide based gamma-secretase inhibitors and its SAR evolution is described. Significant increases in APP potency on the pyrazolopiperidine scaffold over the original N-bicyclic sulfonamide scaffold were achieved and this potency increase translated in an improved in vivo efficacy. (C) 2010 Elsevier Ltd. All rights reserved.