N-(2-(p-tolyl)-3,4-dihydronaphthalen-1-yl)acetamide | 1174743-60-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(2-(p-tolyl)-3,4-dihydronaphthalen-1-yl)acetamide
• 英文别名: N-[2-(4-methylphenyl)-3,4-dihydronaphthalen-1-yl]acetamide
• CAS: 1174743-60-2
• 化学式: C₁₉H₁₉NO
• 分子量: 277.366
• InChiKey: DOLNHXRCGWODHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (4-甲基苯基)(2,4,6-三甲基苯基)碘鎓三氟甲烷磺酸盐 、 N-(3,4-二氢萘-1-基)乙酰胺 在 copper(I) bromide 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以81%的产率得到N-(2-(p-tolyl)-3,4-dihydronaphthalen-1-yl)acetamide
  参考文献：
  名称：

  Copper(I) Bromide Catalyzed Arylation of Cyclic Enamides and Naphthyl-1-acetamides Using Diaryliodonium Salts

  摘要：

  Copper(I) bromide catalyzed direct C-H arylation of cyclic enamides was achieved using diaryliodonium salts in the absence of base/additive at ambient temperature with high yields. A biologically active dihydro[a]benzocarbazole scaffold was synthesized using the established protocol. The scope of the current methodology was further extended for the synthesis of C4-, C7-aryl-substituted 1-naphthyl acetamides in good yields.

  DOI：

  10.1021/jo501162s

文献信息

• Direct arylation of cyclic enamides via Pd(ii)-catalyzed C–H activation
  作者：Hai Zhou、Wan-Jun Chung、Yun-He Xu、Teck-Peng Loh

  DOI：10.1039/b903151k

  日期：——

  A new direct coupling of cyclic enamides with aryl boronic acids viaPd(II)-catalyzed C–H functionalization has been achieved with good yields (up to 90%).

  通过钯（II）催化的 CâH 功能化，实现了环烯丙基酰胺与芳基硼酸的一种新的直接偶联，并取得了良好的收率（高达 90%）。
• Copper(I) Bromide Catalyzed Arylation of Cyclic Enamides and Naphthyl-1-acetamides Using Diaryliodonium Salts
  作者：Muthuraj Prakash、Subramaniam Muthusamy、Venkitasamy Kesavan

  DOI：10.1021/jo501162s

  日期：2014.9.5

  Copper(I) bromide catalyzed direct C-H arylation of cyclic enamides was achieved using diaryliodonium salts in the absence of base/additive at ambient temperature with high yields. A biologically active dihydro[a]benzocarbazole scaffold was synthesized using the established protocol. The scope of the current methodology was further extended for the synthesis of C4-, C7-aryl-substituted 1-naphthyl acetamides in good yields.