吡啶并[3,2-e][1,2,4]三嗪 | 6133-44-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 中文名称: 吡啶并[3,2-e][1,2,4]三嗪
• 英文名称: Pyrido<3,2-e>-as-triazin
• 英文别名: Pyridino(3,2-e)1,2,4-triazine；pyrido[3,2-e][1,2,4]triazine
• CAS: 6133-44-4
• 化学式: C₆H₄N₄
• 分子量: 132.125
• InChiKey: GUODQFHMIYUCLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  吡啶并[3,2-e][1,2,4]三嗪 在 ammonium hydroxide 、 potassium hexacyanoferrate(III) 作用下， 以 水 为溶剂， 反应 120.0h， 以15%的产率得到(9CI)-吡啶并[3,2-e]-1,2,4-噻嗪-5-醇
  参考文献：
  名称：

  Ple, Nelly; Turck, Alain; Queguiner, Guy, Canadian Journal of Chemistry, 1992, vol. 70, # 11, p. 2828 - 2833

  摘要：

  DOI：
• 作为产物：
  描述：

  3-硝基-2-吡啶肼 在 palladium on activated charcoal 盐酸 、 manganese(IV) oxide 、 sodium hydroxide 、 氢气 作用下， 以 乙醇 、 水 为溶剂， 生成 吡啶并[3,2-e][1,2,4]三嗪
  参考文献：
  名称：

  吡啶并[3,4-e] -1,2,4-三嗪和相关杂环作为潜在的抗真菌剂。

  摘要：

  描述了一系列吡啶并[3,4-e] -1,2,4-三嗪，1,2,4-三嗪[5,6-c]喹啉和相关的稠合三嗪的制备和生物学活性。甲基，氨基和酰基氨基取代基置于前一系统的吡啶基环中。其他结构修饰包括在这些环系统的3位上的各种烷基，环烷基，取代的苯基和杂环基。在琼脂稀释测定中，该系列中的活性物质以MIC小于或等于16微克/ mL抑制念珠菌，曲霉，Mucor和Trychophyton菌种。

  DOI：

  10.1021/jm00131a010

文献信息

• [EN] NOVEL HETEROCYCLIC COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS HÉTÉROCYCLIQUES
  申请人：PRISM BIOLAB CO LTD

  公开号：WO2022014724A1

  公开（公告）日：2022-01-20

  A compound of the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof has a superior inhibitory activity on cancer cell proliferation.

  化合物的化学式（I）：其中每个符号如描述中所定义，或其药学上可接受的盐在抑制癌细胞增殖方面具有优越的活性。
• [EN] FUNGICIDES BASED ON NITROGEN-CONTAINING HETEROCYCLES<br/>[FR] FONGICIDES FONDES SUR DES HETEROCYCLES CONTENANT DE L'AZOTE
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2005123698A1

  公开（公告）日：2005-12-29

  The compound of the general formula (I), wherein W, X, Y, Z, R, R1 and R2 are defined as set forth in the specification, useful as fungicide.

  通式（I）的化合物，其中W、X、Y、Z、R、R1和R2如规范中所定义，可用作杀菌剂。
• [EN] MONOBACTAMS AND METHODS OF THEIR SYNTHESIS AND USE<br/>[FR] MONOBACTAMES ET PROCÉDÉS DE SYNTHÈSE ET D'UTILISATION DE CES DERNIERS
  申请人：HARVARD COLLEGE

  公开号：WO2015103583A1

  公开（公告）日：2015-07-09

  Described herein are monobactam antibiotics of Formula (I), (Ι'), (II), and (II'), along with methods and intermediates for preparing these compounds. Pharmaceutical compositions and methods of treating infectious diseases using the monobactams are also provided.

  本文描述了单环内酰胺抗生素的化学式(I)、(Ι')、(II)和(II')，以及制备这些化合物的方法和中间体。还提供了使用单环内酰胺治疗传染病的药物组合物和方法。
• [EN] FUNGICIDES BASED ON NITROGEN-CONTAINING HETEROCYCLES<br/>[FR] FONGICIDES A BASE D'HETEROCYCLES CONTENANT DE L'AZOTE
  申请人：SYNGENTA LTD

  公开号：WO2004056829A1

  公开（公告）日：2004-07-08

  Fungicidal compounds having the general formula (1): formula (1) wherein W, Z and one of X and Y are N and the other one of X and Y is CR8; R8 is H, halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio or halo(C1-4)alkyl; R and R2 are independently H, halo, C1-8 alkyl, C1-8 alkoxy, C1-8 alkylthio, C2-8 alkenyl, C2-8 alkynyl, cyano or NR3R4, provided that at least one of R and R2 is NR3R4; R1 is halo, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkyl(C1-6)­-alkyl, C1-8 alkoxy, C1-8 alkylthio, aryl, aryloxy, arylthio, heteroaryl, heteroaryloxy, heteroarylthio, aryl(C1-4)alkyl, aryl(C1-4)alkoxy, heteroaryl(C1-4)alkyl, heteroaryl­(C1-4)alkoxy, aryl(C1-4)alkylthio, heteroaryl(C1-4)alkylthio, morpholino, piperidino or pyrrolidino; R3 and R4 are independently H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, aryl(C1-8)­- alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl(C1-6)alkyl, heteroaryl, heteroaryl(C1-8)alkyl, NR5R6, provided that not both R3 and R4 are H or NR5R6, or R3 and R4 together form a C3-7 alkylene or C3-7 alkenylene chain optionally substituted with one or more C1-4 alkyl or C1-4 alkoxy groups, or, together with the nitrogen atom to which they are attached, R3 and R4 form a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N-(C1-4)alkyl (especially N-methyl) ring; and R5 and R6 are independently H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, aryl(C1-8)­alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl(C1-6)alkyl, heteroaryl or heteroaryl(C1-8)alkyl; any of the foregoing alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R8) being optionally substituted with halogen, cyano, C1-6 alkoxy, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6 haloalkoxy, C1-6 alkylthio, tri(C1-4)alkylsilyl, C1-6 alkylamino or C1-6 dialkylamino, any of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C1-4 alkyl (especially methyl), and any of the foregoing aryl or heteroaryl groups or moieties being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C2-6 alkenyloxy, C2-6 alkynyloxy, halo(C1-6)alkyl, halo(C1-6)alkoxy, C1-6 alkylthio, halo(C1-6)alkylthio, hydroxy(C1-6)alkyl, C1-4 alkoxy(C1-6)alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, -NR''R'', NHCOR'', -NHCONR''R'', -CONR''R'', -SO2R'', -OSO2R'', -COR'', -CR''=NR'' or -N=CR ''R'', in which R'' and R'' are independently hydrogen, C1-4 alkyl, halo-(C1-4)alkyl, C1-4 alkoxy, halo(C1-4)alkoxy, C1-4 alkylthio, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C1-4 alkyl or C1-4 alkoxy.

  具有通式（1）的杀真菌化合物：式（1）其中W，Z和X和Y中的另一个是N，另一个是CR8；R8是H，卤素，C1-4烷基，C1-4烷氧基，C1-4烷基硫基或卤代（C1-4）烷基；R和R2独立地是H，卤素，C1-8烷基，C1-8烷氧基，C1-8烷基硫基，C2-8烯基，C2-8炔基，氰基或NR3R4，但至少其中之一是NR3R4；R1是卤素，C1-8烷基，C2-8烯基，C2-8炔基，C3-8环烷基，C3-8环烷基（C1-6）-烷基，C1-8烷氧基，C1-8烷基硫基，芳基，芳氧基，芳硫基，杂芳基，杂芳氧基，杂芳硫基，芳基（C1-4）烷基，芳基（C1-4）烷氧基，杂芳基（C1-4）烷基，杂芳基（C1-4）烷氧基，芳基（C1-4）烷基硫基，杂芳基（C1-4）烷基硫基，吗啉基，哌啶基或吡咯啉基；R3和R4独立地是H，C1-8烷基，C2-8烯基，C2-8炔基，芳基，芳基（C1-8）-烷基，C3-8环烷基，C3-8环烷基（C1-6）-烷基，杂芳基，杂芳基（C1-8）-烷基，NR5R6，但不是R3和R4都是H或NR5R6，或R3和R4一起形成一个C3-7烷基或C3-7烯基链，可选择地用一个或多个C1-4烷基或C1-4烷氧基取代，或与它们所连接的氮原子一起，R3和R4形成吗啉，硫吗啉，硫吗啉S-氧化物或硫吗啉S-二氧化物环或哌嗪或哌嗪N-（C1-4）烷基（特别是N-甲基）环；R5和R6独立地是H，C1-8烷基，C2-8烯基，C2-8炔基，芳基，芳基（C1-8）-烷基，C3-8环烷基，C3-8环烷基（C1-6）-烷基，杂芳基或杂芳基（C1-8）-烷基；任何上述烷基，烯基，炔基或环烷基基团（R8除外）可选择地用卤素，氰基，C1-6烷氧基，C1-6烷基羰基，C1-6烷氧羰基，C1-6卤代烷氧基，C1-6烷基硫基，三（C1-4）烷基硅烷基，C1-6烷基氨基或C1-6二烷基氨基取代，上述任何吗啉，硫吗啉，哌啶，哌嗪和吡咯啉环可选择地用C1-4烷基（特别是甲基）取代，上述任何芳基或杂芳基基团可选择地用一个或多个取代基取代，所述取代基选择自卤素，羟基，硫醇基，C1-6烷基，C2-6烯基，C2-6炔基，C1-6烷氧基，C2-6烯氧基，C2-6炔氧基，卤代（C1-6）烷基，卤代（C1-6）烷氧基，C1-6烷基硫基，卤代（C1-6）烷基硫基，羟基（C1-6）烷基，C1-4烷氧基（C1-6）烷基，C3-6环烷基，C3-6环烷基（C1-4）烷基，苯氧基，苄氧基，苯甲酰氧基，氰基，异氰酸基，硫氰酸基，异硫氰酸基，硝基，-NR''R''，NHCOR''，-NHCONR''R''，-CONR''R''，-SO2R''，-OSO2R''，-COR''，-CR''=NR''或-N=CR''R''，其中R''和R''独立地是氢，C1-4烷基，卤代（C1-4）烷基，C1-4烷氧基，卤代（C1-4）烷氧基，C1-4烷基硫基，C3-6环烷基，C3-6环烷基（C1-4）烷基，苯基或苄基，苯基和苄基可选择地用卤素，C1-4烷基或C1-4烷氧基取代。
• Fungicides based on nitrogen-containing heterocycles
  申请人：Crowley Jelf Patrick

  公开号：US20060100203A1

  公开（公告）日：2006-05-11

  Fungicidal compounds having the general formula (1): formula (1) wherein W, Z and one of X and Y are N and the other one of X and Y is CR 8 ; R 8 is H, halo, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylthio or halo(C 1-4 )alkyl; R and R 2 are independently H, halo, C 1-8 alkyl, C 1-8 alkoxy, C 1-8 alkylthio, C 2-8 alkenyl, C 2-8 alkynyl, cyano or NR 3 R 4 , provided that at least one of R and R 2 is NR 3 R 4 ; R 1 is halo, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl(C 1-6 )-alkyl, C 1-8 alkoxy, C 1-8 alkylthio, aryl, aryloxy, arylthio, heteroaryl, heteroaryloxy, heteroarylthio, aryl(C 1-4 )alkyl, aryl(C 1-4 )alkoxy, heteroaryl(C 1-4 )alkyl, heteroaryl(C 1-4 )alkoxy, aryl(C 1-4 )alkylthio, heteroaryl(C 1-4 )alkylthio, morpholino, piperidino or pyrrolidino; R 3 and R 4 are independently H, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, aryl, aryl(C 1-8 )-alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl(C 1-6 )alkyl, heteroaryl, heteroaryl(C 1-8 )alkyl, NR 5 R 6 , provided that not both R 3 and R 4 are H or NR 5 R 6 , or R 3 and R 4 together form a C 3-7 alkylene or C 3-7 alkenylene chain optionally substituted with one or more C 1-4 alkyl or C 1-4 alkoxy groups, or, together with the nitrogen atom to which they are attached, R 3 and R 4 form a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N-(C 1-4 )alkyl (especially N-methyl) ring; and R 5 and R 6 are independently H, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 -alkynyl, aryl, aryl(C 1-8 )alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl(C 1-6 )alkyl, heteroaryl or heteroaryl(C 1-8 )alkyl; any of the foregoing alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R 8 ) being optionally substituted with halogen, cyano, C 1-6 alkoxy, C 1-6 alkylcarbonyl, C 1-6 alkoxycarbonyl, C 1-6 haloalkoxy, C 1-6 alkylthio, tri(C 1-4 )alkylsilyl, C 1-6 alkylamino or C 1-6 dialkylamino, any of the foregoing morpholine, thiomopholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C 1-4 alkyl (especially methyl), and any of the foregoing aryl or heteroaryl groups or moieties being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, halo(C 1-6 )alkyl, halo(C 1-6 )alkoxy, C 1-6 alkylthio, halo(C 1-6 )alkylthio, hydroxy(C 1-6 )alkyl, C 1-4 alkoxy(C 1-6 )alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl(C 1-4 )alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, —NR″′R″″, NHCOR″′, —NHCONR″′R″″, —CONR″′R″″, —SO 2 R″′, —OSO 2 R″′, —COR″′, —CR″′═NR″″ or —N═CR ″′R″″, in which R″′ and R″″ are independently hydrogen, C 1-4 alkyl, halo(C 1-4 )alkyl, C 1-4 alkoxy, halo(C 1-4 )alkoxy, C 1-4 alkylthio, C 3-6 cycloalkyl, C 3-6 cycloalkyl(C 1-4 )alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C 1-4 alkyl or C 1-4 alkoxy.

  具有通式（1）的杀菌化合物：通式（1）其中，W，Z和X和Y中的另一个是CR8，另一个是N；R8为H，卤素，C1-4烷基，C1-4烷氧基，C1-4烷硫基或卤素（C1-4）烷基；R和R2独立地为H，卤素，C1-8烷基，C1-8烷氧基，C1-8烷硫基，C2-8烯基，C2-8炔基，氰基或NR3R4，但其中至少一个为NR3R4；R1为卤素，C1-8烷基，C2-8烯基，C2-8炔基，C3-8环烷基，C3-8环烷基（C1-6）-烷基，C1-8烷氧基，C1-8烷硫基，芳基，芳氧基，芳硫基，杂环芳基，杂环芳氧基，杂环芳硫基，芳基（C1-4）烷基，芳基（C1-4）烷氧基，杂环芳基（C1-4）烷基，杂环芳基（C1-4）烷氧基，芳基（C1-4）烷硫基，杂环芳基（C1-4）烷硫基，吗啉基，哌啶基或吡咯烷基；R3和R4独立地为H，C1-8烷基，C2-8烯基，C2-8炔基，芳基，芳基（C1-8）-烷基，C3-8环烷基，C3-8环烷基（C1-6）烷基，杂环芳基，杂环芳基（C1-8）烷基，NR5R6，但不是R3和R4都为H或NR5R6，或者R3和R4一起形成一个C3-7烷基或C3-7烯基链，可选择地取代一个或多个C1-4烷基或C1-4烷氧基，或者与它们所附着的氮原子一起，R3和R4形成吗啉，硫代吗啉，硫代吗啉S-氧化物或硫代吗啉S-二氧化物环或哌嗪或哌嗪N-（C1-4）烷基（特别是N-甲基）环；R5和R6独立地为H，C1-8烷基，C2-8烯基，C2-8炔基，芳基，芳基（C1-8）-烷基，C3-8环烷基，C3-8环烷基（C1-6）烷基，杂环芳基或杂环芳基（C1-8）烷基；除R8之外的任何上述烷基，烯基，炔基或环烷基基团（均可选择地取代卤素，氰基，C1-6烷氧基，C1-6烷基羰基，C1-6烷氧羰基，C1-6卤烷氧基，C1-6烷硫基，三（C1-4）烷基硅烷基，C1-6烷基氨基或C1-6二烷基氨基），任何上述吗啉，硫代吗啉，哌嗪，哌嗪和吡咯烷环可选择地取代C1-4烷基（特别是甲基），任何上述芳基或杂环芳基基团可选择地取代一个或多个取代基，所述取代基选自卤素，羟基，巯基，C1-6烷基，C2-6烯基，C2-6炔基，C1-6烷氧基，C2-6烯氧基，C2-6炔氧基，卤素（C1-6）烷基，卤素（C1-6）烷氧基，C1-6烷硫基，卤素（C1-6）烷硫基，羟基（C1-6）烷基，C1-4烷氧基（C1-6）烷基，C3-6环烷基，C3-6环烷基（C1-4）烷基，苯氧基，苄氧基，苯甲酰氧基，氰基，异氰基，硫氰酸基，异硫氰酸基，硝基，—NR″′R″″，NHCOR″′，—NHCONR″′R″″，—CONR″′R″″，—SO2R″′，—OSO2R″′，—COR″′，—CR″′═NR″″或—N═CR″′R″″，其中R″′和R″″独立地为氢，C1-4烷基，卤素（C1-4）烷基，C1-4烷氧基，卤素（C1-4）烷氧基，C1-4烷硫基，C3-6环烷基，C3-6环烷基（C1-4）烷基，苯基或苄基，苯基和苄基可选择地取代卤素，C1-4烷基或C1-4烷氧基。