4-(4-Ethyl-piperidin-1-yl)-benzonitrile | 85872-86-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-(4-Ethyl-piperidin-1-yl)-benzonitrile
• 英文别名: 4-(4-Ethyl-1-piperidinyl)benzonitrile；4-(4-ethylpiperidin-1-yl)benzonitrile
• CAS: 85872-86-2
• 化学式: C₁₄H₁₈N₂
• 分子量: 214.31
• InChiKey: XUGYKMQWYNFMOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(4-Ethyl-piperidin-1-yl)-benzonitrile 在 氢氧化钾 作用下， 以 乙二醇 为溶剂， 生成 4-(4-Ethyl-piperidin-1-yl)-benzoic acid
  参考文献：
  名称：

  Adomenas, P.; Sirutkaitis, R., Molecular Crystals and Liquid Crystals (1969-1991), 1985, vol. 124, p. 269 - 276

  摘要：

  DOI：
• 作为产物：
  描述：

  4-乙基吡啶 在 palladium on activated charcoal 氢气 、 sodium 作用下， 以 neat (no solvent) 为溶剂， 生成 4-(4-Ethyl-piperidin-1-yl)-benzonitrile
  参考文献：
  名称：

  Adomenas, P.; Sirutkaitis, R., Molecular Crystals and Liquid Crystals (1969-1991), 1985, vol. 124, p. 269 - 276

  摘要：

  DOI：

文献信息

• Substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs as inhibitors of STAT protein
  申请人：University of Central Florida Research Foundation, Inc.

  公开号：US10196373B2

  公开（公告）日：2019-02-05

  In one aspect, the invention relates to substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs, derivatives thereof, and related compounds, which are useful as inhibitors of STAT protein activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a STAT protein activity dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在一个方面，该发明涉及替代的2-羟基-4-(2-(苯磺酰胺基)乙酰胺基)苯甲酸类似物，其衍生物和相关化合物，这些化合物可用作STAT蛋白活性的抑制剂；制备这些化合物的合成方法；包含这些化合物的药物组合物；以及使用这些化合物和组合物治疗与STAT蛋白活性功能障碍相关的细胞不受控制增殖疾病的方法。本摘要旨在作为在特定领域进行搜索的扫描工具，并不打算限制本发明。
• SUBSTITUTED 2-HYDROXY-4-(2-(PHENYLSULFONAMIDO)ACETAMIDO)BENZOIC ACID ANALOGS AS INHIBITORS OF STAT PROTEIN
  申请人：University of Central Florida Research Foundation, Inc.

  公开号：US20150038708A1

  公开（公告）日：2015-02-05

  In one aspect, the invention relates to substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs, derivatives thereof, and related compounds, which are useful as inhibitors of STAT protein activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a STAT protein activity dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本发明涉及替代的2-羟基-4-(2-(苯磺酰胺)乙酰胺)苯甲酸类似物、其衍生物和相关化合物，它们可以作为STAT蛋白活性的抑制剂；制备这些化合物的合成方法；包含这些化合物的制药组合物；以及使用这些化合物和组合物治疗与STAT蛋白活性功能障碍相关的细胞增殖失控症状的方法。本摘要旨在作为特定领域搜索的扫描工具，不意味着对本发明的限制。
• US8846707B2
  申请人：——

  公开号：US8846707B2

  公开（公告）日：2014-09-30
• [EN] SUBSTITUTED 2-HYDROXY-4-(2-(PHENYLSULFONAMIDO)ACETAMIDO)BENZOIC ACID ANALOGS AS INHIBITORS OF STAT PROTEINS<br/>[FR] ANALOGUES DE L'ACIDE 2-HYDROXY-4-(2-(PHÉNYLSULFONAMIDO)ACÉTAMIDO) BENZOÏQUE SUBSTITUÉ UTILISABLES EN TANT QU'INHIBITEURS DES PROTÉINES STAT
  申请人：UNIV CENTRAL FLORIDA RES FOUND

  公开号：WO2012018868A1

  公开（公告）日：2012-02-09

  In one aspect, the invention relates to substituted substituted 2-hydroxy-4-(2- (phenylsulfonamido)acetamido)benzoic acid analogs, derivatives thereof, and related compounds, which are useful as inhibitors of STAT protein activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a STAT protein activity dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.