dibenzo[b,d]furan-2-d | 101762-08-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: dibenzo[b,d]furan-2-d
• 英文别名: 2-Deuteriodibenzofuran；2-deuteriodibenzofuran
• CAS: 101762-08-7
• 化学式: C₁₂H₈O
• 分子量: 169.187
• InChiKey: TXCDCPKCNAJMEE-MICDWDOJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-溴二苯并呋喃 在 正丁基锂 、 氘代盐酸 作用下， 生成 dibenzo[b,d]furan-2-d
  参考文献：
  名称：

  Peptide synthesis by prior thiol capture. 2. Design of templates for intramolecular O,N-acyl transfer. 4,6-Disubstituted dibenzofurans as optimal spacing elements

  摘要：

  DOI：

  10.1021/jo00360a033

文献信息

• Palladium‐Catalyzed Deuteration of Arylketone Oxime Ethers
  作者：Zhen‐Yu Wang、Xu Zhang、Wen‐Qing Chen、Guo‐Dong Sun、Xing Wang、Lin Tan、Hui Xu、Hui‐Xiong Dai

  DOI：10.1002/anie.202319773

  日期：2024.3.18

  A palladium-catalyzed deuteration of arylketone oxime ethers has been realized. Regioselective deuteration of some biologically important drugs and natural products is showcased via Friedel–Crafts acylation and subsequent deacylative deuteration. Vicinal difunctionalization of electro-rich arenes is achieved by using the ketone as both directing group and leaving group.

  已经实现了芳酮肟醚的钯催化氘化。通过弗里德尔-克拉夫茨酰化和随后的脱酰氘化展示了一些具有重要生物学意义的药物和天然产物的区域选择性氘化。富电芳烃的邻位双官能化是通过使用酮作为导向基团和离去基团来实现的。
• Electroreduction of organic compounds. 31. Electroreduction of 2- and 3-Chlorodibenzofuran in Deuterated Methanol
  作者：J�rgen Voss、Edgar Waller、Petra Kr�nke

  DOI：10.1002/prac.19983400505

  日期：——

  The cathodic reduction of dibenzofuran (2), 2-chlorodibenzofuran (4), and 3-chlorodibenzofuran (1) in deuterated methanol is investigated. The Bh-ch-type reduction product 1,4-dibenzofuran (3) is formed from 1 via 2, whereas 2-chloro-1,4-dihydrodibenzofuran (5) is obtained as by-product besides 3 from 4 as starting compound. Deuterium is only incorporated into the reduction products if CH,OD or CD,OD but not if CD,OH are used. This observation is strongly indicative of a polar mechanism involving protonation rather than a radical mechanism with hydrogen atom abstraction to be operative.