4-[2-(4-fluorophenyl)phenyl]piperidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-[2-(4-fluorophenyl)phenyl]piperidine
• 化学式: C₁₂H₁₃FNO₅PolS
• InChiKey: LWDPQWVKVMWQHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-[2-(4-fluorophenyl)phenyl]piperidine 在 水 、 三氟乙酸 作用下， 生成 N-hydroxy-4-(4-(4-(3-methoxyphenyl)piperazin-1-yl)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide
  参考文献：
  名称：

  Orally bioavailable dual MMP-1/MMP-14 sparing, MMP-13 selective α-sulfone hydroxamates

  摘要：

  A series of phenyl piperidine alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13, are dual-sparing of MMP-1 and MMP-14 (MT1-MMP) and exhibit oral bioavailability in rats. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.130
• 作为产物：
  描述：

  4-(4-Fluoro-benzenesulfonyl)-tetrahydro-pyran-4-carboxylic acid 、 4-O-methylhydroxylaminephenoxymethyl-copoly(styrene-1%-divinylbenzene)-resin 在 N-甲基吗啉 、 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 作用下， 以 N-甲基吡咯烷酮 为溶剂， 生成 4-[2-(4-fluorophenyl)phenyl]piperidine
  参考文献：
  名称：

  MMP-13 selective isonipecotamide α-sulfone hydroxamates

  摘要：

  A series of N-aryl isonipecotamide alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.111

文献信息

• Orally bioavailable dual MMP-1/MMP-14 sparing, MMP-13 selective α-sulfone hydroxamates
  作者：Stephen A. Kolodziej、Susan L. Hockerman、Terri L. Boehm、Jeffery N. Carroll、Gary A. DeCrescenzo、Joseph J. McDonald、Debbie A. Mischke、Grace E. Munie、Theresa R. Fletcher、Joseph G. Rico、Nathan W. Stehle、Craig Swearingen、Daniel P. Becker

  DOI：10.1016/j.bmcl.2010.04.130

  日期：2010.6

  A series of phenyl piperidine alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13, are dual-sparing of MMP-1 and MMP-14 (MT1-MMP) and exhibit oral bioavailability in rats. (C) 2010 Elsevier Ltd. All rights reserved.
• MMP-13 selective isonipecotamide α-sulfone hydroxamates
  作者：Stephen A. Kolodziej、Susan L. Hockerman、Gary A. DeCrescenzo、Joseph J. McDonald、Debbie A. Mischke、Grace E. Munie、Theresa R. Fletcher、Nathan Stehle、Craig Swearingen、Daniel P. Becker

  DOI：10.1016/j.bmcl.2010.04.111

  日期：2010.6

  A series of N-aryl isonipecotamide alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13. (C) 2010 Elsevier Ltd. All rights reserved.