N-(3,5-dimethoxyphenyl)-3-(1-(4-fluoro-3-methoxybenzyl)piperidin-3-yl)propanamide | 1069737-44-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(3,5-dimethoxyphenyl)-3-(1-(4-fluoro-3-methoxybenzyl)piperidin-3-yl)propanamide
• 英文别名: N-(3,5-dimethoxyphenyl)-3-[1-(4-fluoro-3-methoxybenzyl)-3-piperidinyl]propanamide；N-(3,5-dimethoxyphenyl)-3-[1-[(4-fluoro-3-methoxyphenyl)methyl]piperidin-3-yl]propanamide
• CAS: 1069737-44-5
• 化学式: C₂₄H₃₁FN₂O₄
• 分子量: 430.52
• InChiKey: MSRNULIQIBVDIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  60
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-(3-哌啶基)丙酸 1HCL 在 甲醇 、 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 15.5h， 生成 N-(3,5-dimethoxyphenyl)-3-(1-(4-fluoro-3-methoxybenzyl)piperidin-3-yl)propanamide
  参考文献：
  名称：

  COMPOUNDS, COMPOSITIONS AND METHODS OF USE AGAINST STRESS GRANULES

  摘要：

  本文描述了与神经退行性疾病、肌肉骨骼疾病、癌症、眼科疾病和病毒感染相关的细胞内包涵体形成和应激颗粒的调节化合物、组合物和方法。

  公开号：

  US20180305334A1

文献信息

• identification of compounds that disperse tdp-43 inclusions
  申请人：WOLOZIN Benjamin

  公开号：US20140080780A1

  公开（公告）日：2014-03-20

  Herein, methods of modulating inclusion formation and stress granules in cells are described. The methods comprise contacting a cell with an inclusion inhibitor. Methods for screening for modulators of TDP-43 aggregation are also described.
• IDENTIFICATION OF COMPOUNDS THAT DISPERSE TDP-43 INCLUSIONS
  申请人：AQUINNAH PHARMACEUTICALS, INC.

  公开号：US20170088515A1

  公开（公告）日：2017-03-30

  Herein, compounds and compositions for use in treating diseases relating to inclusion formation and stress granules are described. Methods for screening for modulation of TDP-43 aggregation are also described.
• US9359363B2
  申请人：——

  公开号：US9359363B2

  公开（公告）日：2016-06-07
• [EN] IDENTIFICATION OF COMPOUNDS THAT DISPERSE TDP-43 INCLUSIONS<br/>[FR] IDENTIFICATION DE COMPOSÉS QUI DISPERSENT DES INCLUSIONS DE TDP-43
  申请人：WOLOZIN BENJAMIN

  公开号：WO2012162249A1

  公开（公告）日：2012-11-29

  Herein, methods of modulating inclusion formation and stress granules in cells are described. The methods comprise contacting a cell with an inclusion inhibitor. Methods for screening for modulators of TDP-43 aggregation are also described.
• [EN] COMPOUNDS, COMPOSITIONS AND METHODS OF USE AGAINST STRESS GRANULES<br/>[FR] COMPOSÉS, COMPOSITIONS ET MÉTHODES D'UTILISATION CONTRE DES GRANULES DE STRESS
  申请人：AQUINNAH PHARMACEUTICALS INC

  公开号：WO2017066705A1

  公开（公告）日：2017-04-20

  Herein, compounds, compositions and methods for modulating inclusion formation and stress granules in cells related to the onset of neurodegenerative diseases, musculoskeletal diseases, cancer, ophthalmological diseases, and viral infections are described.