1-Methyl-sulfinyl-2-hydroxy-undecan | 22204-26-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 亚砜
• 英文名称: 1-Methyl-sulfinyl-2-hydroxy-undecan
• 英文别名: 1-Methylsulfinyl-undecanol-(2)；1-methanesulfinyl-undecan-2-ol；2-hydroxyundecyl methyl sulfoxide；1-Methylsulfinylundecan-2-ol
• CAS: 22204-26-8
• 化学式: C₁₂H₂₆O₂S
• 分子量: 234.403
• InChiKey: GIFWSCMRWGWNSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  56.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-Methyl-sulfinyl-2-hydroxy-undecan 在 potassium tert-butylate 作用下， 以 叔丁醇 为溶剂， 生成 1-十一烯-3-醇
  参考文献：
  名称：

  The Effect of Methylmercapto, Methylsulfinyl, and Methylsulfonyl Groups on the Equilibrium in Three-Carbon Prototropic Systems

  摘要：

  DOI：

  10.1021/ja01072a048

文献信息

• [EN] THERAPEUTIC PHENETHYLAMINE COMPOSITIONS AND METHODS OF USE<br/>[FR] COMPOSITIONS DE PHÉNÉTHYLAMINE THÉRAPEUTIQUE ET MÉTHODES D'UTILISATION
  申请人：CYBIN IRL LTD

  公开号：WO2022038170A1

  公开（公告）日：2022-02-24

  There are disclosed deuterated 2C-X phenethylamine compounds, the use of such compounds in the treatment of diseases associated with a serotonin 5-HT2 receptor, pharmaceutical compositions such as tablet compositions and kits containing the compounds, methods of delivering the compounds in a mist via inhalation, and methods of treating diseases or disorders associated with a serotonin 5-HT2 receptor, such as central nervous system (CNS) disorders or psychological disorders with the compounds of the invention.

  本文披露了脱氘化的2C-X苯乙胺化合物，以及这些化合物在治疗与5-HT2受体相关的疾病中的应用，包括药用组合物（如片剂组合物）和包含这些化合物的套装，通过雾化吸入途径传递这些化合物的方法，以及使用本发明的化合物治疗与5-HT2受体相关的疾病或疾病的方法，如中枢神经系统（CNS）疾病或心理疾病。
• Transdermal delivery of dobutamine
  申请人：ELI LILLY AND COMPANY

  公开号：EP0492930A2

  公开（公告）日：1992-07-01

  The present invention provides a method for treating cardiac insufficiency in a warm-blooded animal comprising administering dobutamine transdermally, and formulations suitable therefor.

  本发明提供了一种治疗温血动物心功能不全的方法，包括透皮给药多巴酚丁胺和适用于该方法的制剂。
• Transdermal cannabinoid formulations
  申请人：MM Technology Holdings, LLC

  公开号：US10028904B2

  公开（公告）日：2018-07-24

  The present invention includes a transdermal composition which contains a pharmaceutically effective amount of a cannabinoid for delivery of the cannabinoid to the bloodstream of a user. The composition may comprise the following components: a surfactant-lecithin organogel; and a cannabinoid. The composition may also comprise an exogenous terpene. The cannabinoid is capable of diffusing from the composition into the bloodstream of the user, and may be used in methods for treating a patient suffering from a condition such as pain, nausea and emesis, convulsions, muscle spasm, inflammation, depression, and cachexia.

  本发明包括一种透皮组合物，其中含有药用有效量的大麻素，用于将大麻素输送到使用者的血液中。该组合物可包含以下成分：表面活性剂-卵磷脂有机凝胶；大麻素。组合物还可包括一种外源性萜烯。大麻素能够从组合物扩散到使用者的血液中，可用于治疗疼痛、恶心和呕吐、抽搐、肌肉痉挛、炎症、抑郁和恶病质等症状的患者。
• Foamable vehicles and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
  申请人：Foamix Pharmaceuticals Ltd.

  公开号：US10363216B2

  公开（公告）日：2019-07-30

  The present invention teaches a foamable pharmaceutical and cosmetic compositions comprising an aprotic polar solvent; foam compositions and uses thereof.

  本发明涉及一种包含壬烷极性溶剂的可发泡药物和化妆品组合物；泡沫组合物及其用途。
• Delivery of drug nanoparticles and methods of use thereof
  申请人：DFB Soria, LLC

  公开号：US10449162B2

  公开（公告）日：2019-10-22

  Disclosed are compositions and methods useful for enhancing the skin penetration of drug nanoparticles. The compositions can be hydrophobic and include a hydrophobic carrier, a volatile silicone fluid, and drug nanoparticles. Also disclosed are methods for inhibiting crystal growth of drug nanoparticles in an aqueous carrier or a hydrophobic carrier. Further, methods to topically treat psoriasis using compositions containing nanoparticles of paclitaxel or other taxanes are disclosed.

  所公开的是用于增强药物纳米粒子皮肤渗透性的组合物和方法。这些组合物可以是疏水性的，包括疏水载体、挥发性硅油和药物纳米粒子。还公开了在水性载体或疏水性载体中抑制药物纳米粒子晶体生长的方法。此外，还公开了使用含有紫杉醇或其他类固醇的纳米颗粒的组合物局部治疗牛皮癣的方法。