N-(2,2-dimethyladamant-1-yl)piperidine | 1404434-82-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(2,2-dimethyladamant-1-yl)piperidine
• 英文别名: 1-(2,2-Dimethyl-1-adamantyl)piperidine；1-(2,2-dimethyl-1-adamantyl)piperidine
• CAS: 1404434-82-7
• 化学式: C₁₇H₂₉N
• 分子量: 247.424
• InChiKey: ORMSTPJKLLLGII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-(2,2-dimethyladamant-1-yl)piperidine 在 盐酸 作用下， 以 乙醚 为溶剂， 反应 24.0h， 以22%的产率得到N-(2,2-dimethyladamant-1-yl)piperidine hydrochloride
  参考文献：
  名称：

  Synthesis and Anti-influenza A Virus Activity of 2,2-Dialkylamantadines and Related Compounds

  摘要：

  The synthesis of several 2,2-dialkyladamantyl-1-amines through the combination of a Ritter reaction with a Wagner-Meerwein rearrangement from noradamantane alcohols is reported. Several of the novel amines displayed low micromolar activities against several H1N1 influenza virus strains, including the amantadine-resistant A/PuertoRico/8/34 strain. Most of the compounds did not show cytotoxicity for MDCK cells.

  DOI：

  10.1021/ml300279b
• 作为产物：
  描述：

  (2,2-dimethyladamant-1-yl)amine 在 盐酸 、 三乙胺 、 sodium iodide 作用下， 以 乙醚 、 N,N-二甲基甲酰胺 为溶剂， 反应 52.0h， 生成 N-(2,2-dimethyladamant-1-yl)piperidine
  参考文献：
  名称：

  Synthesis and Anti-influenza A Virus Activity of 2,2-Dialkylamantadines and Related Compounds

  摘要：

  The synthesis of several 2,2-dialkyladamantyl-1-amines through the combination of a Ritter reaction with a Wagner-Meerwein rearrangement from noradamantane alcohols is reported. Several of the novel amines displayed low micromolar activities against several H1N1 influenza virus strains, including the amantadine-resistant A/PuertoRico/8/34 strain. Most of the compounds did not show cytotoxicity for MDCK cells.

  DOI：

  10.1021/ml300279b

文献信息

• Synthesis and Anti-influenza A Virus Activity of 2,2-Dialkylamantadines and Related Compounds
  作者：Eva Torres、Roser Fernández、Stéphanie Miquet、Mercè Font-Bardia、Evelien Vanderlinden、Lieve Naesens、Santiago Vázquez

  DOI：10.1021/ml300279b

  日期：2012.12.13

  The synthesis of several 2,2-dialkyladamantyl-1-amines through the combination of a Ritter reaction with a Wagner-Meerwein rearrangement from noradamantane alcohols is reported. Several of the novel amines displayed low micromolar activities against several H1N1 influenza virus strains, including the amantadine-resistant A/PuertoRico/8/34 strain. Most of the compounds did not show cytotoxicity for MDCK cells.