2-甲氧基-4-(1-哌嗪基)苯酚 | 925889-93-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 2-甲氧基-4-(1-哌嗪基)苯酚
• 英文名称: 2-Methoxy-4-(piperazin-1-yl)phenol
• 英文别名: 2-methoxy-4-piperazin-1-ylphenol
• CAS: 925889-93-6
• 化学式: C₁₁H₁₆N₂O₂
• 分子量: 208.26
• InChiKey: JNYQZYVLEBQJSV-UHFFFAOYSA-N

物化性质

• 沸点：
  407.0±45.0 °C(Predicted)
• 密度：
  1.155±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  44.7
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2933599090

反应信息

• 作为反应物：
  描述：

  2-(methylthio)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one 、 2-甲氧基-4-(1-哌嗪基)苯酚 以 乙醇 为溶剂， 以9.3%的产率得到2-[4-(4-Hydroxy-3-methoxyphenyl)piperazin-1-yl]-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one
  参考文献：
  名称：

  Identification of Antitubercular Benzothiazinone Compounds by Ligand-Based Design

  摘要：

  1,3-Benzothiazin-4-ones (BTZs) are a novel class of TB drug candidates with potent activity against M. tuberculosis. An in silico ligand-based model based on structure-activity data from 170 BTZ compounds was used to design a new series. Compounds were tested against a panel of mycobacterial strains and were profiled for cytotoxicity, stability, and antiproliferative effects. Several of the compounds showed improved activity against MDR-TB while retaining low toxicity with higher microsomal, metabolic, and plasma stability.

  DOI：

  10.1021/jm3008882

文献信息

• NOVEL CARBAMOYLOXY ARYLALKANOYL ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND AND METHOD FOR TREATING PAIN, ANXIETY AND DEPRESSION BY ADMINISTERING THE COMPOUND
  申请人：Kwak Byong Sung

  公开号：US20110195963A1

  公开（公告）日：2011-08-11

  There is provided a novel carbamoyloxy arylalkanoyl arylpiperazine derivative compound having abundant racemic or enantiomeric characteristics, represented by the Formula 1, and pharmaceutically available salts or hydrates thereof. Also, there are provided a pharmaceutical composition for treating pain, anxiety or depression including an effective amount of the compound, and a method for treating pain, anxiety or depression in mammals by administering an effective amount of the compound to the mammals in need of treatment thereof.

  提供一种新颖的卡巴莫氧基芳基丙酰基芳基哌嗪衍生物化合物，具有丰富的外消旋或对映体特征，其化学式如下所示，并且提供其药用盐或水合物。此外，还提供了一种用于治疗疼痛、焦虑或抑郁的药物组合物，包括一定量的该化合物，并且提供了一种治疗哺乳动物疼痛、焦虑或抑郁的方法，通过向需要治疗的哺乳动物施用一定量的该化合物。
• NOVEL CARBAMOYLOXY ARYLALKAN ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND AND METHOD FOR TREATING PAIN, ANXIETY AND DEPRESSION BY ADMINISTERING THE COMPOUND
  申请人：Lee Ki Ho

  公开号：US20100160331A1

  公开（公告）日：2010-06-24

  There is provided a novel carbamoyloxy arylalkanoyl arylpiperazine derivative compound having abundant racemic or enantiomeric characteristics, represented by the Formula 1, and pharmaceutically available salts or hydrates thereof. Also, there are provided a pharmaceutical composition for treating pain, anxiety or depression including an effective amount of the compound, and a method for treating pain, anxiety or depression in mammals by administering an effective amount of the compound to the mammals in need of treatment thereof.

  本发明提供了一种新型的卡巴莫氧基芳基丙酰基芳基哌嗪衍生物化合物，具有丰富的外消旋或对映异构体特性，其化学式为1，并提供其药用盐或水合物。此外，还提供了一种用于治疗疼痛、焦虑或抑郁的制药组合物，包括有效量的该化合物，以及一种治疗哺乳动物疼痛、焦虑或抑郁的方法，通过向需要治疗的哺乳动物中给予有效量的该化合物。
• METHOD FOR TREATING PAIN, ANXIETY OR DEPRESSION USING CARBAMOYLOXY ALKANOYL PIPERAZINE COMPOUND
  申请人：SK Biopharmaceuticals Co., Ltd.

  公开号：US20140088095A1

  公开（公告）日：2014-03-27

  There is provided a novel carbamoyloxy arylalkanoyl arylpiperazine derivative compound having abundant racemic or enantiomeric characteristics, represented by the Formula 1, and pharmaceutically available salts or hydrates thereof. Also, there are provided a pharmaceutical composition for treating pain, anxiety or depression including an effective amount of the compound, and a method for treating pain, anxiety or depression in mammals by administering an effective amount of the compound to the mammals in need of treatment thereof.

  提供了一种新型的卡巴莫氧基芳基烷酰基芳基哌嗪衍生物化合物，具有丰富的外消旋或对映异构体特性，其表示为式1，并且可获得其药用盐或水合物。此外，还提供了一种用于治疗疼痛、焦虑或抑郁症的药物组合物，包括有效量的该化合物，以及一种通过向需要治疗的哺乳动物中给予有效量的该化合物来治疗疼痛、焦虑或抑郁症的方法。
• US8541409B2
  申请人：——

  公开号：US8541409B2

  公开（公告）日：2013-09-24
• US8901116B2
  申请人：——

  公开号：US8901116B2

  公开（公告）日：2014-12-02