2,3-dimethyl-1,10-phenanthroline | 107919-96-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: 2,3-dimethyl-1,10-phenanthroline
• 英文别名: 2,4-dimethyl-[1,10]phenanthroline；2,4-Dimethyl-[1,10]phenanthrolin；1,10-Phenanthroline, 2,4-dimethyl-；2,4-dimethyl-1,10-phenanthroline
• CAS: 107919-96-0
• 化学式: C₁₄H₁₂N₂
• 分子量: 208.263
• InChiKey: KXSJVVRUZOPMJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-bromo-3-[(Z)-2-(2-bromopyridin-3-yl)ethenyl]-4,6-dimethylpyridine 在 铜 作用下， 以 N-甲基吡咯烷酮 为溶剂， 以62%的产率得到2,3-dimethyl-1,10-phenanthroline
  参考文献：
  名称：

  A new approach to the 1,10-phenanthroline core

  摘要：

  A protocol for the synthesis of substituted 1,10-phenanthrolines is reported. The phenanthroline scaffold has been obtained constructing the central cycle starting from two pyridine rings. The method is hinged upon the intramolecular coupling of eiv-1,2-di(2-bromo-3-pyridyl)ethenes that are in turn obtained from the Wittig reaction of 2-bromonicotinalclehydes with phosphonium salts prepared from 2-bromo-3-(bromomethyl)pyridines. Yields up to 75% have been obtained. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.03.073

文献信息

• [1,10]-PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES
  申请人：Martinez Gil Ana

  公开号：US20100240692A1

  公开（公告）日：2010-09-23

  The present invention relates to a new family of [1,10]-phenantroline derivatives of formula (I), which are useful for the treatment or profilaxis of a neurodegenerative or haematological disease or condition, their use as a medicament, especially for treating a treatment neurodegenerative or haematological disease or condition, and a pharmaceutical composition comprising the compounds.

  本发明涉及一种新的公式（I）的[1,10]-菲啰啉衍生物家族，其用于治疗或预防神经退行性或血液学疾病或状况，以及它们作为药物的用途，特别是用于治疗神经退行性或血液学疾病或状况的药物，以及包含这些化合物的药物组合物。
• SUBSTITUTED 1, 10-PHENANTHROLINES. VII. SYNTHESIS OF CERTAIN PHENANTHROLINES FOR USE IN THE DETECTION OF Cu(I)¹
  作者：FRANCIS H. CASE、JAMES A. BRENNAN

  DOI：10.1021/jo01371a007

  日期：1954.6
• US5006660A
  申请人：——

  公开号：US5006660A

  公开（公告）日：1991-04-09
• A new approach to the 1,10-phenanthroline core
  作者：Giorgio Chelucci、Daniele Addis、Salvatore Baldino

  DOI：10.1016/j.tetlet.2007.03.073

  日期：2007.5

  A protocol for the synthesis of substituted 1,10-phenanthrolines is reported. The phenanthroline scaffold has been obtained constructing the central cycle starting from two pyridine rings. The method is hinged upon the intramolecular coupling of eiv-1,2-di(2-bromo-3-pyridyl)ethenes that are in turn obtained from the Wittig reaction of 2-bromonicotinalclehydes with phosphonium salts prepared from 2-bromo-3-(bromomethyl)pyridines. Yields up to 75% have been obtained. (c) 2007 Elsevier Ltd. All rights reserved.