4-[bis(4-dimethylaminophenyl)methyl]benzoic acid methyl ester | 34101-38-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 4-[bis(4-dimethylaminophenyl)methyl]benzoic acid methyl ester
• 英文别名: CLMG methyl ester；carboxyleucomalachite green methyl ester
• CAS: 34101-38-7
• 化学式: C₂₅H₂₈N₂O₂
• 分子量: 388.51
• InChiKey: YPDSZSPPLQFEFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.79
• 重原子数：
  29.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  32.78
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  4-[bis(4-dimethylaminophenyl)methyl]benzoic acid methyl ester 在 盐酸 、 二氧化铅 作用下， 以 水 为溶剂， 生成 carboxymalachite green methyl ester
  参考文献：
  名称：

  Production of Antibodies for Selective Detection of Malachite Green and the Related Triphenylmethane Dyes in Fish and Fishpond Water

  摘要：

  This study provides a practical method for production of the antibodies against malachite green (MG) and its primary metabolite leucomalachite green (LMG). Two ELISA kits are constructed with the MG and LMG antibodies for detection of the residual MG and LMG in fish muscle and fishpond water. The detection limit is established at the level of 0.05 mu g/L for both MG and LMG. Our ELISA kits show the advantages of good specificity, high sensitivity, and convenience in rapid screening of MG and LMG residues. The sample of fishpond water, without extraction or prior preparation, is directly assayed by the ELISA kit. More then 80 fish samples can be simultaneously tested in a kit. The toxic crystal violet and its metabolite leucocrystal violet of illegal use in aquaculture are detected by our prepared MG and LMG antibodies, whereas the antibodies do not cross-react with common antibiotics, sulfonamides, and benzene derivatives.

  DOI：

  10.1021/jf071195y
• 作为产物：
  描述：

  N,N-二甲基苯胺 、 对甲酰基苯甲酸甲酯 在 硫酸 作用下， 反应 40.0h， 以88%的产率得到4-[bis(4-dimethylaminophenyl)methyl]benzoic acid methyl ester
  参考文献：
  名称：

  Production of Antibodies for Selective Detection of Malachite Green and the Related Triphenylmethane Dyes in Fish and Fishpond Water

  摘要：

  This study provides a practical method for production of the antibodies against malachite green (MG) and its primary metabolite leucomalachite green (LMG). Two ELISA kits are constructed with the MG and LMG antibodies for detection of the residual MG and LMG in fish muscle and fishpond water. The detection limit is established at the level of 0.05 mu g/L for both MG and LMG. Our ELISA kits show the advantages of good specificity, high sensitivity, and convenience in rapid screening of MG and LMG residues. The sample of fishpond water, without extraction or prior preparation, is directly assayed by the ELISA kit. More then 80 fish samples can be simultaneously tested in a kit. The toxic crystal violet and its metabolite leucocrystal violet of illegal use in aquaculture are detected by our prepared MG and LMG antibodies, whereas the antibodies do not cross-react with common antibiotics, sulfonamides, and benzene derivatives.

  DOI：

  10.1021/jf071195y

文献信息

• Brønsted Acidic Ionic Liquid Catalyzed Three-Component Friedel–Crafts Reaction for the Synthesis of Unsymmetrical Triarylmethanes
  作者：Uthaiwan Sirion、Suttida Rinkam、Warapong Senapak、Sarayut Watchasit、Rungnapha Saeeng

  DOI：10.1055/a-1809-7768

  日期：2022.9

  A convenient and practical method for the synthesis of unsymmetrical triarylmethanes was demonstrated through a one-pot three-component double Friedel–Crafts reaction of various aliphatic, aromatic, or heteroaromatic aldehydes with N,N-dialkylanilines and indoles by using a Brønsted acidic ionic liquid as the catalyst. This method was successfully applied under metal- and solvent-free conditions at

  通过使用布朗斯台德酸性离子液体，各种脂肪族、芳香族或杂芳香族醛与N , N - 二烷基苯胺和吲哚的一锅三组分双傅克反应，证明了一种方便实用的合成不对称三芳基甲烷的方法作为催化剂。该方法在 80 °C 的无金属和无溶剂条件下成功应用，从广泛的底物中以中等至高产率提供了相应的不对称三芳基甲烷产物。此外，通过定量NMR分析研究了该反应的机理。