13-bis(4-methoxyphenyl)-13-phenyl-4-oxo-8,9-dithia-5,12-dioxatridecanoic acid | 124685-38-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 13-bis(4-methoxyphenyl)-13-phenyl-4-oxo-8,9-dithia-5,12-dioxatridecanoic acid
• 英文别名: 4-[2-[2-[Bis(4-methoxyphenyl)-phenylmethoxy]ethyldisulfanyl]ethoxy]-4-oxobutanoic acid
• CAS: 124685-38-7
• 化学式: C₂₉H₃₂O₇S₂
• 分子量: 556.701
• InChiKey: PUHAIPNVRVFOOQ-UHFFFAOYSA-N

物化性质

• 沸点：
  699.8±55.0 °C(Predicted)
• 密度：
  1.250±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  38
• 可旋转键数：
  17
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  142
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  对硝基苯酚 、 13-bis(4-methoxyphenyl)-13-phenyl-4-oxo-8,9-dithia-5,12-dioxatridecanoic acid 在 吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 1,4-二氧六环 为溶剂， 以70%的产率得到1-O-[2-[2-[bis(4-methoxyphenyl)-phenylmethoxy]ethyldisulfanyl]ethyl] 4-O-(4-nitrophenyl) butanedioate
  参考文献：
  名称：

  Solid-phase preparation of 5′,3′-heterobifunctional oligodeoxyribonucleotides using modified solid supports

  摘要：

  The solid-phase preparation of oligodeoxyribonucleotides attached to intercalator or reactive groups through their 5'- and (or) 3'-ends is reported. These syntheses implicate the introduction of suitable masked functional groups at the 5'-end of the oligonucleotide by the intermediate of their phosphoramidite derivatives or at the 3'-end of the oligonucleotide using modified solid supports. After full deblocking, the functional groups (phosphate, thiophosphate, primary amine or thiol) can be reacted with the suitable reactive group involved in the chosen ligand. These methods allow the preparation of heterobifunctional derivatized oligodeoxyribonucleotides.

  DOI：

  10.1016/s0040-4020(01)90786-0
• 作为产物：
  描述：

  4,4'-双甲氧基三苯甲基氯 在 吡啶 、 4-二甲氨基吡啶 作用下， 生成 13-bis(4-methoxyphenyl)-13-phenyl-4-oxo-8,9-dithia-5,12-dioxatridecanoic acid
  参考文献：
  名称：

  Solid-phase preparation of 5′,3′-heterobifunctional oligodeoxyribonucleotides using modified solid supports

  摘要：

  The solid-phase preparation of oligodeoxyribonucleotides attached to intercalator or reactive groups through their 5'- and (or) 3'-ends is reported. These syntheses implicate the introduction of suitable masked functional groups at the 5'-end of the oligonucleotide by the intermediate of their phosphoramidite derivatives or at the 3'-end of the oligonucleotide using modified solid supports. After full deblocking, the functional groups (phosphate, thiophosphate, primary amine or thiol) can be reacted with the suitable reactive group involved in the chosen ligand. These methods allow the preparation of heterobifunctional derivatized oligodeoxyribonucleotides.

  DOI：

  10.1016/s0040-4020(01)90786-0

文献信息

• Solid-phase preparation of 5′,3′-heterobifunctional oligodeoxyribonucleotides using modified solid supports
  作者：Ulysse Asseline、Edwige Bonfils、Robin Kurfürst、Marcel Chassignol、Victoria Roig、Nguyen Thanh Thuong

  DOI：10.1016/s0040-4020(01)90786-0

  日期：1992.1

  The solid-phase preparation of oligodeoxyribonucleotides attached to intercalator or reactive groups through their 5'- and (or) 3'-ends is reported. These syntheses implicate the introduction of suitable masked functional groups at the 5'-end of the oligonucleotide by the intermediate of their phosphoramidite derivatives or at the 3'-end of the oligonucleotide using modified solid supports. After full deblocking, the functional groups (phosphate, thiophosphate, primary amine or thiol) can be reacted with the suitable reactive group involved in the chosen ligand. These methods allow the preparation of heterobifunctional derivatized oligodeoxyribonucleotides.
• ASSELINE, U.;THUONG, NGUYEN T., TETRAHEDRON LETT., 30,(1989) N9, C. 2521-2524
  作者：ASSELINE, U.、THUONG, NGUYEN T.

  DOI：——

  日期：——
• A Useful Disulfide Linker for Single-Bead Analysis of Peptide Libraries
  作者：Oliver Lack、Hans Zbinden、Wolf-D. Woggon

  DOI：10.1002/1522-2675(200202)85:2<495::aid-hlca495>3.0.co;2-e

  日期：2002.2

  A disulfide-linker for conventional peptide synthesis, attached to a PEGA-resin, has been developed. Reductive hydrolysis cleaves the linker within minutes, liberating the synthesized peptide for rapid sequencing by tandem mass spectrometry. The method has been tested for ten peptides in a single-bead fashion.