4-(9-羟基-9-夹氧蒽基)苯甲酸 | 191168-41-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 4-(9-羟基-9-夹氧蒽基)苯甲酸
• 英文名称: 9-hydroxy-9-(4-carboxyphenyl)xanthene
• 英文别名: 4-(9-hydroxyxanthen-9-yl)benzoic acid
• CAS: 191168-41-9
• 化学式: C₂₀H₁₄O₄
• 分子量: 318.329
• InChiKey: SQPFUMCXWJCFAI-UHFFFAOYSA-N

物化性质

• 熔点：
  193-195 °C (dec.)
• 沸点：
  525.4±50.0 °C(Predicted)
• 密度：
  1.388±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  9-hydroxy-9-(4-methylphenyl)xanthene 在 potassium permanganate 作用下， 以65%的产率得到4-(9-羟基-9-夹氧蒽基)苯甲酸
  参考文献：
  名称：

  9-Hydroxy-9-(4-carboxyphenyl)xanthene — A new linker for the synthesis of peptide amides

  摘要：

  The easy synthesis of 9-hydroxy-9-(4-carboxyphenyl)xanthene 1 a new linker for the solid phase peptide synthesis of peptide amides is reported. The cleavage conditions were checked and several peptide amides were synthesized using the TentaGel-resin(TM) on the Milligen 9050 continuous flow peptide synthesizer. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00706-5

文献信息

• [EN] A SOLID-SUPPORTED HYDROXY AMINO ACID AND A SOLID-SUPPORTED AMINO ALCOHOL<br/>[FR] ACIDE AMINÉ HYDROXY SUPPORTÉ PAR UN SOLIDE ET ALCOOL AMINÉ SUPPORTÉ PAR UN SOLIDE
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2020027737A1

  公开（公告）日：2020-02-06

  There is provided a solid-supported hydroxy amino acid or a solid-supported amino alcohol of Formula (I) as defined herein. There is further provided a method of making the solid-supported hydroxy amino acid or the solid-supported amino alcohol. There is further provided a method of making a peptide alcohol by using the solid-supported hydroxy amino acid or the solid-supported amino alcohol. There is also provided a peptide alcohol, obtained by using the solid-supported hydroxy amino acid or the solid-supported amino alcohol. There is also provided a stapled peptide alcohol and medical uses thereof.

  提供了一种固体支持的羟基氨基酸或式(I)中定义的固体支持的氨基醇。还提供了制备固体支持的羟基氨基酸或固体支持的氨基醇的方法。还提供了使用固体支持的羟基氨基酸或固体支持的氨基醇制备肽醇的方法。还提供了通过使用固体支持的羟基氨基酸或固体支持的氨基醇获得的肽醇。还提供了一种经过钉住的肽醇及其医疗用途。
• 9-Hydroxy-9-(4-carboxyphenyl)xanthene — A new linker for the synthesis of peptide amides
  作者：Bernd Henkel、Weiguang Zeng、Ernst Bayer

  DOI：10.1016/s0040-4039(97)00706-5

  日期：1997.5

  The easy synthesis of 9-hydroxy-9-(4-carboxyphenyl)xanthene 1 a new linker for the solid phase peptide synthesis of peptide amides is reported. The cleavage conditions were checked and several peptide amides were synthesized using the TentaGel-resin(TM) on the Milligen 9050 continuous flow peptide synthesizer. (C) 1997 Elsevier Science Ltd.