2-benzyl-4-benzylidene-3,4-dihydrobenzo[f][1,2]thiazepin-5(2H)-one 1,1-dioxide | 1153687-48-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫铬烷
• 英文名称: 2-benzyl-4-benzylidene-3,4-dihydrobenzo[f][1,2]thiazepin-5(2H)-one 1,1-dioxide
• CAS: 1153687-48-9
• 化学式: C₂₃H₁₉NO₃S
• 分子量: 389.475
• InChiKey: UOAXDULVGHIJFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.16
• 重原子数：
  28.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  54.45
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-benzyl-4-benzylidene-3,4-dihydrobenzo[f][1,2]thiazepin-5(2H)-one 1,1-dioxide 、 乙烯基乙醚 以62%的产率得到
  参考文献：
  名称：

  α-Haloarylsulfonamides: multiple cyclization pathways to skeletally diverse benzofused sultams

  摘要：

  The development of new methods to skeletally diverse sultams based oil a central alpha-halo benzene sulfonamide building block is reported. Several salient features of this building block are Utilized ill multiple reaction pathways, including the Fleck reaction, C- and O-arylation, Sonogashira-Pauson-Khand, Sonogashira-intramolecular hydroamination, and domino aza-Michael-Heck for the generation of five-, six-, and seven-membered benzofused bicyclic and tricyclic sultams. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.11.053
• 作为产物：
  描述：

  3,4-dihydro-2-(phenylmethyl)-1,2-benzothiazepin-5(2H)-one 1,1-dioxide 、 苯甲醛 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以80%的产率得到2-benzyl-4-benzylidene-3,4-dihydrobenzo[f][1,2]thiazepin-5(2H)-one 1,1-dioxide
  参考文献：
  名称：

  α-Haloarylsulfonamides: multiple cyclization pathways to skeletally diverse benzofused sultams

  摘要：

  The development of new methods to skeletally diverse sultams based oil a central alpha-halo benzene sulfonamide building block is reported. Several salient features of this building block are Utilized ill multiple reaction pathways, including the Fleck reaction, C- and O-arylation, Sonogashira-Pauson-Khand, Sonogashira-intramolecular hydroamination, and domino aza-Michael-Heck for the generation of five-, six-, and seven-membered benzofused bicyclic and tricyclic sultams. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.11.053