3-(1-Naphthyl)-3-phenylpropionsaeure-methylester | 78811-60-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-(1-Naphthyl)-3-phenylpropionsaeure-methylester
• 英文别名: methyl 3-(naphthalen-1-yl)-3-phenylpropanoate；methyl 3-naphthalen-1-yl-3-phenylpropanoate
• CAS: 78811-60-6
• 化学式: C₂₀H₁₈O₂
• 分子量: 290.362
• InChiKey: VPIHLBKSTXJSOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.53
• 重原子数：
  22.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  methyl (E)-3-naphthalen-1-yl-3-phenylprop-2-enoate 以14%的产率得到
  参考文献：
  名称：

  KAUPP G.; STARK M., CHEM. BER., 1981, 114, NO 6, 2217-2237

  摘要：

  DOI：

文献信息

• Synergistic N‐Heterocyclic Carbene/Palladium‐Catalyzed Umpolung 1,4‐Addition of Aryl Iodides to Enals
  作者：Wenjun Yang、Bo Ling、Bowen Hu、Haolin Yin、Jianyou Mao、Patrick J. Walsh

  DOI：10.1002/anie.201912584

  日期：2020.1.2

  promoted by cooperative (terpy)Pd/NHC catalysis was developed that generates various bioactive β,β-diaryl propanoate derivatives. This system is not only the first reported palladium-catalyzed arylation of NHC-bound homoenolates but also expands the scope of NHC-induced umpolung transformations. A diverse array of functional groups such as esters, nitriles, alcohols, and heterocycles are tolerated under

  开发了一种由配合式（叔）Pd / NHC催化促进的将碘化芳基碘化为1，4-烯醇的化合物，可生成各种具有生物活性的β，β-二芳基丙酸酯衍生物。该系统不仅是首次报道的钯催化的NHC结合的均烯酸酯的芳基化反应，而且扩大了NHC诱导的umpolung转化的范围。在温和的条件下可以耐受各种官能团，例如酯，腈，醇和杂环。该方法还规避了对湿气敏感的有机金属试剂的使用。
• Chiral olefin–sulfoxide as ligands for rhodium-catalyzed asymmetric conjugate addition of arylboronic acids to unsaturated esters
  作者：Feng Xue、Dongping Wang、Xincheng Li、Boshun Wan

  DOI：10.1039/c3ob41342j

  日期：——

  An efficient rhodium/olefin–sulfoxide catalyzed asymmetric conjugate addition of organoboronic acids to various unsaturated esters has been developed, where 2-methoxy-1-naphthyl sulfinyl functionalized olefin ligands have been shown to be highly effective, and are especially applicable to unsaturated methyl esters with up to 99% yield and 91% ee.

  已经开发出有效的铑/烯烃-亚砜催化的有机硼酸向各种不饱和酯的不对称共轭加成反应，其中2-甲氧基-1-萘亚磺酰基官能化的烯烃配体已被证明是高效的，特别适用于不饱和甲酯产率高达99％，ee高达91％。
• Kaupp, Gerd; Stark, Michael, Chemische Berichte, 1981, vol. 114, # 6, p. 2217 - 2237
  作者：Kaupp, Gerd、Stark, Michael

  DOI：——

  日期：——