4-chloro-6-morpholin-4-yl-N-propan-2-yl-1,3,5-triazin-2-amine | 132905-56-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 4-chloro-6-morpholin-4-yl-N-propan-2-yl-1,3,5-triazin-2-amine
• CAS: 132905-56-7
• 化学式: C₁₀H₁₆ClN₅O
• 分子量: 257.723
• InChiKey: VDPCEFVQYYXWDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  63.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-chloro-6-morpholin-4-yl-N-propan-2-yl-1,3,5-triazin-2-amine 在 二环己烷并-18-冠醚-6 potassium fluoride 作用下， 反应 4.0h， 生成 2-Morpholino-4-isopropylamino-6-fluor-s-triazin
  参考文献：
  名称：

  Synthesis of fluoro-substituted symmetrical dialkylaminotriazines under interphase-catalysis conditions

  摘要：

  DOI：

  10.1007/bf00472187
• 作为产物：
  描述：

  2,4-二氯-6-吗啉基-1,3,5-三嗪 、 异丙胺 以 异丙醇 为溶剂， 生成 4-chloro-6-morpholin-4-yl-N-propan-2-yl-1,3,5-triazin-2-amine
  参考文献：
  名称：

  Kinetic studies on the Reaction of Cyanuric Chloride with Amines

  摘要：

  The individual steps in the reactions of cyanuric chloride with n-butyl amine in N-methyl pyrrolidone (NMP) and with morpholine in isopropanol (i-PrOH) were followed kinetically. The ratio of the exchange rates of the first, the second and the third chlorine atom was unexpectedly high in both cases. The reactions of n-butylamino dichlorotriazine with several amines were studied kinetically both in NMP and in i-PrOH. Linear free-energy relationships exist both between our values in NMP and in isopropanol and between our values and reaction rates of p-nitro fluorobenzene with the corresponding amines (in DMSO) determined by Suhr.

  DOI：

  10.1002/prac.19953370128

文献信息

• NIKOLAEVA, S. V.;KOLBIN, A. M.;SAPOZHNIKOV, O. E.;VALITOV, R. B.;IVANOV, +, XIMIYA GETEROTSIKL. SOED.,(1990) N0, S. 1370-1372
  作者：NIKOLAEVA, S. V.、KOLBIN, A. M.、SAPOZHNIKOV, O. E.、VALITOV, R. B.、IVANOV, +

  DOI：——

  日期：——
• Kinetic studies on the Reaction of Cyanuric Chloride with Amines
  作者：Gerhard Just、Ina Pokorny、Wilhelm Pritzkow

  DOI：10.1002/prac.19953370128

  日期：——

  The individual steps in the reactions of cyanuric chloride with n-butyl amine in N-methyl pyrrolidone (NMP) and with morpholine in isopropanol (i-PrOH) were followed kinetically. The ratio of the exchange rates of the first, the second and the third chlorine atom was unexpectedly high in both cases. The reactions of n-butylamino dichlorotriazine with several amines were studied kinetically both in NMP and in i-PrOH. Linear free-energy relationships exist both between our values in NMP and in isopropanol and between our values and reaction rates of p-nitro fluorobenzene with the corresponding amines (in DMSO) determined by Suhr.
• Synthesis of fluoro-substituted symmetrical dialkylaminotriazines under interphase-catalysis conditions
  作者：S. V. Nikolaeva、A. M. Kolbin、Yu. E. Sapozhnikov、R. B. Valitov、V. F. Ivanov

  DOI：10.1007/bf00472187

  日期：1990.10