(E)-13-(tert-Butyl-dimethyl-silanyloxy)-6-methoxymethoxy-tridec-7-en-3-yn-2-ol | 136894-00-3

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (E)-13-(tert-Butyl-dimethyl-silanyloxy)-6-methoxymethoxy-tridec-7-en-3-yn-2-ol
• CAS: 136894-00-3
• 化学式: C₂₁H₄₀O₄Si
• 分子量: 384.632
• InChiKey: ZJCVEEFRYZDTDY-RVDMUPIBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.89
• 重原子数：
  26.0
• 可旋转键数：
  12.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  47.92
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (E)-13-(tert-Butyl-dimethyl-silanyloxy)-6-methoxymethoxy-tridec-7-en-3-yn-2-ol 、 甲基磺酰氯 在 三乙胺 作用下， 生成 Methanesulfonic acid (E)-12-(tert-butyl-dimethyl-silanyloxy)-5-methoxymethoxy-1-methyl-dodec-6-en-2-ynyl ester
  参考文献：
  名称：

  Synthesis of macrocyclic homopropargylic alcohols through intramolecular SE' addition of allenylstannanes and their subsequent conversion to 2,5-furanocycles

  摘要：

  The 2,5-furanocyclododecenes 16, 20, and 24 have been prepared by a new route involving intramolecular S(E)' addition of propargylic stannanes 3, 6, and 9 then exposure of the derived allenones 14, 19, and 23 to AgN-O3-CaCO3 in aqueous acetone at room temperature.

  DOI：

  10.1021/jo00022a008
• 作为产物：
  描述：

  (E)-11-(tert-Butyl-dimethyl-silanyloxy)-undec-5-en-1-yn-4-ol 在 正丁基锂 、 N,N-二异丙基乙胺 作用下， 生成 (E)-13-(tert-Butyl-dimethyl-silanyloxy)-6-methoxymethoxy-tridec-7-en-3-yn-2-ol
  参考文献：
  名称：

  Synthesis of macrocyclic homopropargylic alcohols through intramolecular SE' addition of allenylstannanes and their subsequent conversion to 2,5-furanocycles

  摘要：

  The 2,5-furanocyclododecenes 16, 20, and 24 have been prepared by a new route involving intramolecular S(E)' addition of propargylic stannanes 3, 6, and 9 then exposure of the derived allenones 14, 19, and 23 to AgN-O3-CaCO3 in aqueous acetone at room temperature.

  DOI：

  10.1021/jo00022a008