1,2-Bis(2-chlorophenyl)1,2-bis(3-chlorophenyl)ethane | 126517-27-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1,2-Bis(2-chlorophenyl)1,2-bis(3-chlorophenyl)ethane
• 英文别名: 1-[1,2-Bis(2-chlorophenyl)-2-(3-chlorophenyl)ethyl]-3-chlorobenzene
• CAS: 126517-27-9
• 化学式: C₂₆H₁₈Cl₄
• 分子量: 472.241
• InChiKey: LAYQVHBWWCIQBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  2,3'-Dichlorobenzhydryl Chloride 在 1-(2-羟乙基)-4-甲基哌嗪 、 sodium hydride 作用下， 以 1,4-二氧六环 、 甲苯 为溶剂， 反应 5.0h， 以51%的产率得到1,2-Bis(2-chlorophenyl)1,2-bis(3-chlorophenyl)ethane
  参考文献：
  名称：

  Jilek, Jiri; Urban, Jiri; Kmonicek, Vojtech, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 8, p. 2248 - 2260

  摘要：

  DOI：

文献信息

• Potential Nootropic Agents: Synthesis of Some 1,4-Disubstituted 2-Oxopyrrolidines and Some Related Compounds
  作者：Vladimír Valenta、Jiří Urban、Jan Taimr、Zdeněk Polívka

  DOI：10.1135/cccc19941126

  日期：——

  4-(Aminomethyl)-1-benzyl-2-oxopyrrolidine (VI) was transformed by treatment with (4-benzhydrylpiperazin-1-yl)carbonyl chlorides IIIb - IIId and with (4-methylpiperazin-1-yl)carbonyl chloride (IIIa) to the carboxamides IVa - IVd. Heating of 1-(ethoxycarbonylmethyl)-2,4-dioxopyrrolidine (XIX) in acetonitrile in the presence of water afforded XVIIIa. Treatment with ammonia led to the diamide XVIIIc, while alkaline hydrolysis of XVIIIa gave the dicarboxylic acid XVIIIb. 4-(Aminomethyl)-1-(4-methylthiobenzyl)-2-oxopyrrolidine (XII) was prepared by the reaction of 4-(methylthio)benzylamine with itaconic acid and the following sequence of reactions starting from the obtained carboxylic acid VII including esterification, reduction and treatment the obtained alcohol IX with thionyl chloride, synthesis of phthalimido derivative XI and hydrazinolysis. Amine XII added to 4-chlorophenyl isocyanate formed XIII. The compounds prepared were tested for nootropic activity.

  4-(氨甲基)-1-苄基-2-氧代吡咯烷（VI）经过与（4-苄基哌嗪-1-基）羰基氯化物IIIb - IIId和（4-甲基哌嗪-1-基）羰基氯化物（IIIa）处理后转化为羧酰胺IVa - IVd。在乙腈中加水加热1-(乙氧羰基甲基)-2,4-二氧代吡咯烷（XIX）得到XVIIIa。与氨处理得到二酰胺XVIIIc，碱性水解XVIIIa得到二羧酸XVIIIb。4-(氨甲基)-1-(4-甲硫基苄基)-2-氧代吡咯烷（XII）通过4-(甲硫基)苄胺与顺丁二酸反应以及从得到的羧酸VII开始的一系列反应制备，包括酯化、还原和用氯化亚砜处理得到的醇IX，合成邻苯二甲酰亚胺衍生物XI和水解。胺XII加入4-氯苯基异氰酸酯形成XIII。制备的化合物进行了智力活性测试。
• JILEK, JII;URBAN, JIRI;KMONICEK, VOJTECH;POMYKACEK, JOSEF;HOLUBEK, JIRI;S+, COLLECT. CZECHOSL. CHEM. COMMUN., 54,(1989) N, C. 2248-2260
  作者：JILEK, JII、URBAN, JIRI、KMONICEK, VOJTECH、POMYKACEK, JOSEF、HOLUBEK, JIRI、S+

  DOI：——

  日期：——
• Jilek, Jiri; Urban, Jiri; Kmonicek, Vojtech, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 8, p. 2248 - 2260
  作者：Jilek, Jiri、Urban, Jiri、Kmonicek, Vojtech、Pomykacek, Josef、Holubek, Jiri、et al.

  DOI：——

  日期：——