diallyl benzyl phosphate | 96652-94-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: diallyl benzyl phosphate
• 英文别名: Benzyl bis(prop-2-enyl) phosphate
• CAS: 96652-94-7
• 化学式: C₁₃H₁₇O₄P
• 分子量: 268.249
• InChiKey: MJOTZIKKXVPNNA-UHFFFAOYSA-N

物化性质

• 沸点：
  101-102 °C(Press: 0.02 Torr)
• 密度：
  1.126±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  diallyl benzyl phosphate 在 四(三苯基膦)钯 、 5,5-二甲基-1,3-环己二酮 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 生成 磷酸二氢苄酯
  参考文献：
  名称：

  SAR directed design and synthesis of novel β(1-4)-Glucosyltransferase inhibitors and Their In vitro inhibition studies

  摘要：

  This paper describes SAR directed design and synthesis of novel beta(1-4)-glucosyltransferase (BGT) inhibitors. The designed inhibitors 1-5 provide conformational mimicry of the transition-state in glucosyltransfer reactions. The compounds were tested for in vitro inhibitory activity against (BGT) and the inhibition kinetics were examined. Three of the designed molecules were found to be potential inhibitors of BGT having IC50 values in micromolar (muM) range. Useful structure-activity relationships were established, which provide guidelines for the design Of future generations of inhibitors of BGT. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00371-6
• 作为产物：
  描述：

  己二烯 N,N-二异丙基亚磷酰胺 在 四氮唑 、 叔丁基过氧化氢 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 2.5h， 生成 diallyl benzyl phosphate
  参考文献：
  名称：

  SAR directed design and synthesis of novel β(1-4)-Glucosyltransferase inhibitors and Their In vitro inhibition studies

  摘要：

  This paper describes SAR directed design and synthesis of novel beta(1-4)-glucosyltransferase (BGT) inhibitors. The designed inhibitors 1-5 provide conformational mimicry of the transition-state in glucosyltransfer reactions. The compounds were tested for in vitro inhibitory activity against (BGT) and the inhibition kinetics were examined. Three of the designed molecules were found to be potential inhibitors of BGT having IC50 values in micromolar (muM) range. Useful structure-activity relationships were established, which provide guidelines for the design Of future generations of inhibitors of BGT. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00371-6

文献信息

• PHENYLPROPIONIC ACID DERIVATIVE AND USE THEREOF
  申请人：MORITA Kohei

  公开号：US20100093819A1

  公开（公告）日：2010-04-15

  A compound represented by the following general formula (1) or a salt thereof, which has superior inhibitory activity against type 4 PLA 2 , and thus has prostaglandin and/or leucotriene production suppressing action [X represents a halogen atom, an alkyl group which may be substituted, or the like, Y represents hydrogen atom or an alkyl group which may be substituted, and Z represents hydrogen atom or an alkyl group which may be substituted].

  由以下一般式（1）表示的化合物或其盐，具有优越的抑制对4型PLA2的活性，因此具有前列腺素和/或白三烯产生抑制作用【X代表卤素原子、可能被取代的烷基或类似物，Y代表氢原子或可能被取代的烷基，Z代表氢原子或可能被取代的烷基】。
• A convenient method for phosphorylation using triallyl phosphite
  作者：Si-Zhe Li、Mohammed Ahmar、Yves Queneau、Laurent Soulère

  DOI：10.1016/j.tetlet.2015.06.030

  日期：2015.8

  direct method for the phosphorylation of alcohols, phenols, saccharides and nucleosides using triallyl phosphite is described. From primary or secondary alcohols, the corresponding diallyl-protected phosphorylated compounds are obtained in good to high yields. The method was found to be selective for primary alcohols and to be applicable to diverse simple and functionalized alcohols, including amino acids

  描述了使用亚磷酸三烯丙酯将醇，酚，糖和核苷磷酸化的直接方法。从伯醇或仲醇，以高产率到高产率获得相应的二烯丙基保护的磷酸化化合物。发现该方法对伯醇是选择性的，并且适用于多种简单和功能化的醇，包括氨基酸，碳水化合物和核苷。
• DUAL PROTECTED PRO-COELENTERAZINE SUBSTRATES
  申请人：PROMEGA CORPORATION

  公开号：US20180072781A1

  公开（公告）日：2018-03-15

  Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.

  描述了腔肠素类似物、制备该类似物的方法、包含该类似物的试剂盒，以及利用这些化合物进行基于荧光素酶的检测的方法。
• Dual protected pro-coelenterazine substrates
  申请人：PROMEGA CORPORATION

  公开号：US10316070B2

  公开（公告）日：2019-06-11

  Described are coelenterazine analogs, methods for making the analogs, kits comprising the analogs, and methods of using the compounds for the detection of luminescence in luciferase-based assays with low backgrounds and enhanced signal-to-background ratios. The coelenterazine analogs include compounds of formula (I):

  本发明描述了腔肠素类似物、制造这些类似物的方法、包含这些类似物的试剂盒，以及使用这些化合物在基于荧光素酶的检测中以低背景和增强的信噪比检测发光的方法。腔肠素类似物包括式(I)化合物：
• US8334314B2
  申请人：——

  公开号：US8334314B2

  公开（公告）日：2012-12-18