2-Amino-4-dimethylamino-6-ethyl-symm.-triazin | 21320-33-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 2-Amino-4-dimethylamino-6-ethyl-symm.-triazin
• 英文别名: 6-ethyl-N,N-dimethyl-[1,3,5]triazine-2,4-diamine；6-ethyl-2-N,2-N-dimethyl-1,3,5-triazine-2,4-diamine
• CAS: 21320-33-2
• 化学式: C₇H₁₃N₅
• 分子量: 167.214
• InChiKey: NEPDEQVCXJYRIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-硝基糠醛 、 2-Amino-4-dimethylamino-6-ethyl-symm.-triazin 在 硫酸 作用下， 以 溶剂黄146 为溶剂， 生成 N,N-dimethyl-6-[1-methyl-2-(5-nitro-furan-2-yl)-vinyl]-[1,3,5]triazine-2,4-diamine
  参考文献：
  名称：

  合成抗菌剂。I.硝基糠基乙烯基-s-三嗪衍生物。

  摘要：

  DOI：

  10.1021/jm00301a010

文献信息

• Biguanide compositions and methods of treating metabolic disorders
  申请人：Elcelyx Therapeutics, Inc.

  公开号：US10028923B2

  公开（公告）日：2018-07-24

  Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.

  本文提供了通过施用包含双胍类或相关杂环化合物（如二甲双胍）的组合物来治疗某些疾病（包括糖尿病、肥胖症和其他代谢性疾病、失调或病症）的方法。本文还提供了双胍类或相关杂环化合物组合物及其用于本发明方法的制备方法。本文还提供了包含二甲双胍及其盐类的组合物和使用方法。
• Biguanide Compositions and Methods of Treating Metabolic Disorders
  申请人：Elcelyx Therapeutics, Inc.

  公开号：US20170202790A1

  公开（公告）日：2017-07-20

  Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
• Synthetic antibacterials. I. Nitrofurylvinyl-s-triazine derivatives
  作者：Sadao Nishigaki、Fumio Yoneda、Hideko Matsumoto、Keiko Morinaga

  DOI：10.1021/jm00301a010

  日期：1969.1