(R)-methyl 2-amino-3-((4-methoxyphenyl)diphenylmethylthio)propanoate | 946846-46-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (R)-methyl 2-amino-3-((4-methoxyphenyl)diphenylmethylthio)propanoate
• 英文别名: methyl (2R)-2-amino-3-[(4-methoxyphenyl)-diphenylmethyl]sulfanylpropanoate
• CAS: 946846-46-4
• 化学式: C₂₄H₂₅NO₃S
• 分子量: 407.533
• InChiKey: JINSIHHRPCXDRA-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  86.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (R)-methyl 2-amino-3-((4-methoxyphenyl)diphenylmethylthio)propanoate 、 乙酰氯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 生成 (R)-methyl 2-acetamido-3-((4-methoxyphenyl)diphenylmethylthio)propanoate
  参考文献：
  名称：

  Synthesis and biological evaluation of l-cysteine derivatives as mitotic kinesin Eg5 inhibitors

  摘要：

  Inhibition of Eg5 represents a novel approach for the treatment of cancer. Here, we report the synthesis and structure-activity relationship of S-trityl-L-cysteine (STLC) derivatives as Eg5 inhibitors. Some of these derivatives such as 4f demonstrated enhanced inhibitory activity against Eg5 and induced mitotic arrest with characteristic monoastral spindles in HeLa cells. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.04.101
• 作为产物：
  描述：

  4-甲氧基三苯基氯甲烷 在 氯化亚砜 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (R)-methyl 2-amino-3-((4-methoxyphenyl)diphenylmethylthio)propanoate
  参考文献：
  名称：

  Synthesis and biological evaluation of l-cysteine derivatives as mitotic kinesin Eg5 inhibitors

  摘要：

  Inhibition of Eg5 represents a novel approach for the treatment of cancer. Here, we report the synthesis and structure-activity relationship of S-trityl-L-cysteine (STLC) derivatives as Eg5 inhibitors. Some of these derivatives such as 4f demonstrated enhanced inhibitory activity against Eg5 and induced mitotic arrest with characteristic monoastral spindles in HeLa cells. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.04.101

文献信息

• Synthesis and biological evaluation of l-cysteine derivatives as mitotic kinesin Eg5 inhibitors
  作者：Naohisa Ogo、Shinya Oishi、Kenji Matsuno、Jun-ichi Sawada、Nobutaka Fujii、Akira Asai

  DOI：10.1016/j.bmcl.2007.04.101

  日期：2007.7

  Inhibition of Eg5 represents a novel approach for the treatment of cancer. Here, we report the synthesis and structure-activity relationship of S-trityl-L-cysteine (STLC) derivatives as Eg5 inhibitors. Some of these derivatives such as 4f demonstrated enhanced inhibitory activity against Eg5 and induced mitotic arrest with characteristic monoastral spindles in HeLa cells. (C) 2007 Elsevier Ltd. All rights reserved.