2-[5-溴-2-(三苯基甲氧基)苯基]-1,3-二氧杂环戊烷 | 206860-51-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 中文名称: 2-[5-溴-2-(三苯基甲氧基)苯基]-1,3-二氧杂环戊烷
• 中文别名: 2-(5-溴-2-三苯甲基苯氧基)-1,3-二氧戊环
• 英文名称: 2-(5-bromo-2-trityloxyphenyl)-1,3-dioxolane
• CAS: 206860-51-7
• 化学式: C₂₈H₂₃BrO₃
• 分子量: 487.393
• InChiKey: IONBEWLKWSJGRD-UHFFFAOYSA-N

物化性质

• 熔点：
  160-164 °C(lit.)

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-[5-溴-2-(三苯基甲氧基)苯基]-1,3-二氧杂环戊烷 在 三苯基膦钯 sodium carbonate 作用下， 以 苯并噻吩-2-硼酸 、 苯 为溶剂， 以69%的产率得到2-[4-Trityloxy-3-(1,3-dioxolan-2-yl)phenyl]-benzo[b]thiophene
  参考文献：
  名称：

  Antithrombotic agents

  摘要：

  这个应用涉及到公式I的新化合物（及其药用盐），如本文所定义，用于它们的制备的过程和中间体，包含公式I的新化合物的药物配方，以及将公式I的化合物用作凝血酶抑制剂。

  公开号：

  US06284756B1

文献信息

• A Simple and Efficient Chemoselective Method for the Catalytic Deprotection of Acetals and Ketals Using Bismuth Triflate
  作者：Marc D. Carrigan、Dusan Sarapa、Russell C. Smith、Laura C. Wieland、Ram S. Mohan

  DOI：10.1021/jo016180s

  日期：2002.2.1

  Bismuth triflate is a highly efficient catalyst (0.1-1 mol %) for the deprotection of acetals and ketals. The procedure is very facile and selective for acetals derived from ketones and conjugated aldehydes. tert-Butyldimethylsilyl ethers are stable to the reaction conditions. The highly catalytic nature of bismuth triflate and the use of a relatively nontoxic solvent system (THF/H(2)O) make this procedure

  三氟甲基磺酸铋是一种高效的催化剂（0.1-1 mol％），用于缩醛和缩酮的脱保护。该方法非常简便，对衍生自酮和共轭醛的缩醛具有选择性。叔丁基二甲基甲硅烷基醚对反应条件稳定。三氟甲磺酸铋的高度催化性质和相对无毒的溶剂系统（THF / H（2）O）的使用使该程序特别适合大规模合成。
• Iron(III) tosylate-catalyzed deprotection of aromatic acetals in water
  作者：Margaret E. Olson、James P. Carolan、Michael V. Chiodo、Phillip R. Lazzara、Ram S. Mohan

  DOI：10.1016/j.tetlet.2010.05.112

  日期：2010.7

  The deprotection of aromatic as well as conjugated acetals and ketals in water is catalyzed by iron(III) tosylate (1.0–5.0 mol %). Iron(III) tosylate is an inexpensive and readily available catalyst. The use of water, the most environmentally benign solvent, makes this procedure especially attractive for acetal deprotection.

  甲苯磺酸铁（III）（1.0-5.0 mol％）催化水中芳香族化合物以及共轭缩醛和缩酮的脱保护。甲苯磺酸铁（III）是一种廉价且容易获得的催化剂。使用水（对环境最无害的溶剂）使该程序对于缩醛脱保护特别有吸引力。
• Microbially-Mediated Environmental Influences on Metazoan Colonization of Matground Ecosystems: Evidence from the Lower Cambrian Harkless Formation
  作者：J. V. BAILEY、F. A. CORSETTI、D. J. BOTTJER、K. N. MARENCO

  DOI：10.2110/palo.2005-p05-51e

  日期：2006.6.1

  Pro-Ordovician times, microbial mats may have covered large expanses of the continental shelf Evidence of mat-grounds in shallow-marine settings is provided by abundant wrinkle structures in Lower Cambrian strata of the Great Basin, United States. Wrinkle structures from the Lower Cambrian Harkless Formation commonly co-occur with a distinctive assemblage of invertebrate fossils, providing evidence for the possibility of selective metazoan colonization of matground substrates. Molds of linguliform brachiopods are abundant on many wrinkle surfaces. The agglutinated problematicum, Volborthella tenuis, also is found on wrinkle surfaces and in laminations beneath wrinkle-structure surfaces. Bedding-parallel trace fossils, such as Planolites, Diplichnites, and Taphrhelminthopsis, commonly crosscut wrinkle structures, while vertically oriented trace fossils are absent.Microbial mats containing layered microbial communities would have considerably compressed stratified redox zones beneath the sediment-water interface in marine-shelf settings. Sulfidic and anoxic conditions within and beneath Microbial mats would have precluded habitation by many mnetazoans, while those that adapted to such conditions may have found matgrounds a unique, though temporally fleeting, ecological niche. The distinctive, low-diversity fossil assemblage found in association with the wrinkle structures in the Great Basin suggests that some early animals may have been adapted to hypoxic and sulfidic conditions found in matground substrates, while others may have been physiologically excluded from these environments.
• ANTITHROMBOTIC AGENTS
  申请人：ELI LILLY AND COMPANY

  公开号：EP0993300A1

  公开（公告）日：2000-04-19
• EP0993300A4
  申请人：——

  公开号：EP0993300A4

  公开（公告）日：2002-07-31