7,8-Dihydro-6-methoxy-6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-6H-1,3-dioxolo(4,5-g)(1)benzopyran | 116409-22-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: 7,8-Dihydro-6-methoxy-6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-6H-1,3-dioxolo(4,5-g)(1)benzopyran
• 英文别名: 6-methoxy-6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]chromene
• CAS: 116409-22-4
• 化学式: C₂₂H₂₆O₇
• 分子量: 402.444
• InChiKey: PUPNUUAELIUWCY-UHFFFAOYSA-N

物化性质

• 沸点：
  473.2±45.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  64.6
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  6H-1,3-Dioxolo(4,5-g)(1)benzopyran-6-ol, 7,8-dihydro-6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)- 、 甲醇 生成 7,8-Dihydro-6-methoxy-6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-6H-1,3-dioxolo(4,5-g)(1)benzopyran
  参考文献：
  名称：

  JURD, LEONARD, J. HETEROCYCL. CHEM., 25,(1988) N 1, 89-96

  摘要：

  DOI：

文献信息

• Podophyllotoxin derivatives as igf-1r inhibitors
  申请人：Axelson Magnus

  公开号：US20070123491A1

  公开（公告）日：2007-05-31

  The invention refers to new compounds, e.g. podophyllotoxin derivatives, as well as to the use thereof and of known compounds as specific inhibitors of the insulin-like growth factor-1 receptor (IGF-1R). Said compounds can be used for treatment of IGF-1/IGF-1R dependent diseases, such as cancer, psoriasis, arteriosclerosis, certain endocrine and metabolic disorders etc.

  该发明涉及新化合物，例如鬼臼毒素衍生物，以及将其和已知化合物用作胰岛素样生长因子-1受体（IGF-1R）的特异性抑制剂。这些化合物可用于治疗IGF-1/IGF-1R依赖性疾病，例如癌症、银屑病、动脉硬化、某些内分泌和代谢紊乱等。
• Chemical entities that kill senescent cells for use in treating age-related disease
  申请人：Unity Biotechnology, Inc.

  公开号：US10195213B2

  公开（公告）日：2019-02-05

  Disclosed herein are compounds that are effective for treatment of various disease states associated with senescence. The disclosed compounds can be used to eliminate senescent cells for disease treatment. The dosing of the compounds includes both single administration and regimens of cycling dosages.

  本文公开的化合物可有效治疗与衰老有关的各种疾病状态。所公开的化合物可用于消除衰老细胞以治疗疾病。化合物的给药方式包括单次给药和循环给药。
• JURD, LEONARD, J. HETEROCYCL. CHEM., 25,(1988) N 1, 89-96
  作者：JURD, LEONARD

  DOI：——

  日期：——
• COMPOUNDS AND THERAPEUTIC USES
  申请人：Unity Biotechnology, Inc.

  公开号：US20170281649A1

  公开（公告）日：2017-10-05

  Disclosed herein are compounds that are effective for treatment of various disease states associated with senescence. The disclosed compounds can be used to eliminate senescent cells for disease treatment. The dosing of the compounds includes both single administration and regimens of cycling dosages.