3-(4-chlorophenyl)-2-hydrazino-5,6,7,8-tetrahydrobenzo(b)thiophene[2,3-d]pyrimidine-4(3H)-one | 934246-66-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: 3-(4-chlorophenyl)-2-hydrazino-5,6,7,8-tetrahydrobenzo(b)thiophene[2,3-d]pyrimidine-4(3H)-one
• 英文别名: 3-(4-chlorophenyl)-2-hydrazino-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one；3-(4-Chlorophenyl)-2-hydrazinyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one
• CAS: 934246-66-9
• 化学式: C₁₆H₁₅ClN₄OS
• 分子量: 346.84
• InChiKey: YXBCNOIJUMPTQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  99
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(4-chlorophenyl)-2-hydrazino-5,6,7,8-tetrahydrobenzo(b)thiophene[2,3-d]pyrimidine-4(3H)-one 、 二硫化碳 在 吡啶 作用下， 反应 20.0h， 生成 4-(chlorophenyl)-1-mercapto-6,7,8,9-tetrahydrobenzo[b]thieno[2,3-b][1,2,4]triazolo[3,4-b]pyrimidin-5(4H)-one
  参考文献：
  名称：

  Synthesis of novel bioactive derivatives of 3-(4-chlorophenyl)-2-hydrazino-5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidine-4(3H)-ones

  摘要：

  A series of triazolo[4,3-a]tetrahydrobenzo(b)thieno[3,2-e]pyrimidine-5(4H)-ones (12a-n) were synthesized and evaluated for CNS depressant, skeletal muscle relaxant and anticonvulsant activities by photoactometer, Rotarod and pentylenetetrazole induced the convulsions method respectively in Swiss albino mice. Diazepam was used as standard drug. The five derivatives 12b, 12c, 12d, 12i and 12m showed the CNS depressant and skeletal muscle relaxant activities comparable to those of diazepam at a dose of 5 mg/kg. These derivatives also exhibited good activity when tested for anticonvulsant activity in mice at different dose levels. The ED50 values for these derivatives are in the range of 4.40-9.33 mg/kg. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.05.027
• 作为产物：
  描述：

  3-(4-chlorophenyl)-2-thioxo-2,3,5,6,7,8-hexahydro-1H-benzo[4,5]thieno[2,3-d]-pyrimidin-4-one 在 吡啶 、 一水合肼 作用下， 反应 15.0h， 以75%的产率得到3-(4-chlorophenyl)-2-hydrazino-5,6,7,8-tetrahydrobenzo(b)thiophene[2,3-d]pyrimidine-4(3H)-one
  参考文献：
  名称：

  Synthesis of Some Thienopyrimidine Derivatives

  摘要：

  硫代噻吩嘧啶酮、烷硫基和芳烷硫噻吩嘧啶酮、噻吩嘧啶酮、噻吩嘧啶、噻吩嘧啶二酮及噻吩三唑嘧啶酮通过2-氨基-3-羧乙氧基-4,5-二取代噻吩和2-氨基-3-氰基-4,5-二取代噻吩与不同试剂的反应制备得到。

  DOI：

  10.3390/11070498

文献信息

• Synthesis of Some Thienopyrimidine Derivatives
  作者：Fatma El-Baih、Hanan Al-Blowy、Hassan Al-Hazimi

  DOI：10.3390/11070498

  日期：——

  Thioxothienopyrimidinones, alkylthio- and arylalkylthiothienopyrimidinones, thienopyrimidinones, thienopyrimidines a thienopyrimidinedione and a thienotriazolo- pyrimidinone were prepared from 2-amino-3-carboethoxy-4,5-disubstituted thiophenes and 2-amino-3-cyano-4,5-disubstituted thiophenes via reactions with different reagents.

  硫代噻吩嘧啶酮、烷硫基和芳烷硫噻吩嘧啶酮、噻吩嘧啶酮、噻吩嘧啶、噻吩嘧啶二酮及噻吩三唑嘧啶酮通过2-氨基-3-羧乙氧基-4,5-二取代噻吩和2-氨基-3-氰基-4,5-二取代噻吩与不同试剂的反应制备得到。
• Synthesis of novel bioactive derivatives of 3-(4-chlorophenyl)-2-hydrazino-5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidine-4(3H)-ones
  作者：Sunil V. Gupta、Kamalkishor Baheti、Rajesh Bora、Deepak Dekhane、Mahesh Chhabría、Murlidhar Shingare、Shivaji Pawar、C.J. Shishoo、S.N. Thore

  DOI：10.1016/j.ejmech.2009.05.027

  日期：2009.11

  A series of triazolo[4,3-a]tetrahydrobenzo(b)thieno[3,2-e]pyrimidine-5(4H)-ones (12a-n) were synthesized and evaluated for CNS depressant, skeletal muscle relaxant and anticonvulsant activities by photoactometer, Rotarod and pentylenetetrazole induced the convulsions method respectively in Swiss albino mice. Diazepam was used as standard drug. The five derivatives 12b, 12c, 12d, 12i and 12m showed the CNS depressant and skeletal muscle relaxant activities comparable to those of diazepam at a dose of 5 mg/kg. These derivatives also exhibited good activity when tested for anticonvulsant activity in mice at different dose levels. The ED50 values for these derivatives are in the range of 4.40-9.33 mg/kg. (C) 2009 Elsevier Masson SAS. All rights reserved.