bis(N-methyl-2,2,2-trifluoroacetamido)methylphenylsilane | 1173908-58-1

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: bis(N-methyl-2,2,2-trifluoroacetamido)methylphenylsilane
• 英文别名: 2,2,2-trifluoro-N-methyl-N-[methyl-[methyl-(2,2,2-trifluoroacetyl)amino]-phenylsilyl]acetamide
• CAS: 1173908-58-1
• 化学式: C₁₃H₁₄F₆N₂O₂Si
• 分子量: 372.342
• InChiKey: RMJLRUASJWADCH-UHFFFAOYSA-N

物化性质

• 沸点：
  267.5±50.0 °C(Predicted)
• 密度：
  1.33±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.01
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (S)-2-(p-methoxyanilino)-2-phenylethanol 、 bis(N-methyl-2,2,2-trifluoroacetamido)methylphenylsilane 以 四氢呋喃 为溶剂， 以64%的产率得到(2R,4S)-2-methyl-3-(p-methoxyphenyl)-2,4-diphenyl-1,3,2-oxazosilolidine
  参考文献：
  名称：

  Stereocontrolled synthesis of tertiary silanes via optically pure 1,3,2-oxazasilolidine derivatives

  摘要：

  Optically pure 1,3,2-oxazasilolidine derivatives were synthesized from a chiral 1,2-amino alcohol. These heterocyclic compounds containing a stereogenic silicon atom produced tertiary silanes with excellent optical purity through successive reactions with Grignard reagents and diisobutylaluminum hydride. Stereochemical course of the reactions of the oxazasilolidine at the chiral silicon atom was elucidated based on the absolute configurations of the products and the substrate which were determined by chiral HPLC and X-ray crystallographic analyses. (C) 2009 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2009.02.022
• 作为产物：
  描述：

  N-甲基-2,2,2-三氟乙酰胺 、 甲基苯基二氯硅烷 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 4.0h， 以70%的产率得到bis(N-methyl-2,2,2-trifluoroacetamido)methylphenylsilane
  参考文献：
  名称：

  Stereocontrolled synthesis of tertiary silanes via optically pure 1,3,2-oxazasilolidine derivatives

  摘要：

  Optically pure 1,3,2-oxazasilolidine derivatives were synthesized from a chiral 1,2-amino alcohol. These heterocyclic compounds containing a stereogenic silicon atom produced tertiary silanes with excellent optical purity through successive reactions with Grignard reagents and diisobutylaluminum hydride. Stereochemical course of the reactions of the oxazasilolidine at the chiral silicon atom was elucidated based on the absolute configurations of the products and the substrate which were determined by chiral HPLC and X-ray crystallographic analyses. (C) 2009 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2009.02.022

文献信息

• Stereocontrolled synthesis of tertiary silanes via optically pure 1,3,2-oxazasilolidine derivatives
  作者：Natsuhisa Oka、Masahiko Nakamura、Naomi Soeda、Takeshi Wada

  DOI：10.1016/j.jorganchem.2009.02.022

  日期：2009.6

  Optically pure 1,3,2-oxazasilolidine derivatives were synthesized from a chiral 1,2-amino alcohol. These heterocyclic compounds containing a stereogenic silicon atom produced tertiary silanes with excellent optical purity through successive reactions with Grignard reagents and diisobutylaluminum hydride. Stereochemical course of the reactions of the oxazasilolidine at the chiral silicon atom was elucidated based on the absolute configurations of the products and the substrate which were determined by chiral HPLC and X-ray crystallographic analyses. (C) 2009 Elsevier B. V. All rights reserved.