(2S,4S,6S)-1,3,3-trimethyl-2,6-diphenylpiperidin-4-ol | 42180-02-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (2S,4S,6S)-1,3,3-trimethyl-2,6-diphenylpiperidin-4-ol
• CAS: 42180-02-9；43051-58-7
• 化学式: C₂₀H₂₅NO
• 分子量: 295.425
• InChiKey: XWROHDFSOVWFRR-FHWLQOOXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2S,4S,6S)-1,3,3-trimethyl-2,6-diphenylpiperidin-4-ol 在 溴 作用下， 以 水 、 溶剂黄146 为溶剂， 生成 4-Piperidinone, 1,3,3-trimethyl-2,6-diphenyl-
  参考文献：
  名称：

  Natarajan, K.; Jambulingam, M.; Selvaraj, K., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1984, vol. 23, # 9, p. 901 - 903

  摘要：

  DOI：

文献信息

• Jambulingam, M.; Nanjappan, P.; Natarajan, K., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1986, vol. 25, p. 390 - 394
  作者：Jambulingam, M.、Nanjappan, P.、Natarajan, K.、Ramalingam, K.

  DOI：——

  日期：——
• Kinetics of oxidation of heterocyclic secondary alcohols byN-chloro-r-2,c-6-diphenyl-t-3 methyl piperidin-4-one (NCP) in perchloric acid medium
  作者：Kuppusamy Selvaraj、Vinayagam Venkateswaran、Krishnasamy Ramarajan

  DOI：10.1002/kin.550260806

  日期：1994.8

  AbstractAn investigation of the kinetics of oxidation of epimeric piperidin‐4‐ols, oxan‐4‐ols, and cyclohexanol by N‐chloro‐r‐2, c‐6‐diphenyl‐t‐3‐methylpiperidin‐4‐one (NCP) in aqueous acetic acid in the presence of perchloric acid shows that the reaction is first‐order each in substrate and oxidant. Both H3O+ and Cl− which catalyze the reaction, exhibit a fractional order kinetics. While increase in ionic strength increases the rate slightly, an inverse dependence is observed between rate and solvent polarity. Addition of r‐2‐c‐6‐diphenyl‐t‐3‐methylpiperidin‐4‐one, one of the reaction products, did not influence the rate. Also, no kinetic isotope effect has been observed. A plausible mechanism consistent with these observations is proposed and the relative reactivities of the substrates are explained on conformational grounds. © 1994 John Wiley & Sons, Inc.