1-methyl-3-vinyl-piperidine | 57502-64-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-methyl-3-vinyl-piperidine
• 英文别名: 1-Methyl-3-vinyl-piperidin；3-Ethenyl-1-methylpiperidine
• CAS: 57502-64-4
• 化学式: C₈H₁₅N
• 分子量: 125.214
• InChiKey: HAEXMTHECJCALW-UHFFFAOYSA-N

物化性质

• 沸点：
  142.8±29.0 °C(Predicted)
• 密度：
  0.904±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-methyl-3-vinyl-piperidine 在 盐酸 、 tin 作用下， 生成 1-甲基哌啶
  参考文献：
  名称：

  Ladenburg, Chemische Berichte, 1898, vol. 31, p. 289

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 作用下， 生成 1-methyl-3-vinyl-piperidine
  参考文献：
  名称：

  Lipp, Justus Liebigs Annalen der Chemie, 1897, vol. 294, p. 158

  摘要：

  DOI：

文献信息

• Allosteric Modulators of Metabotropic Glutamate Receptors
  申请人：Bessis Anne-Sophie

  公开号：US20070219187A1

  公开（公告）日：2007-09-20

  The present invention relates to new compounds of formula (I) wherein A, B, P, Q, W, R 1 and R 2 are defined in the description; invention compounds are useful in the prevention or treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors.

  本发明涉及公式(I)的新化合物，其中A、B、P、Q、W、R1和R2在说明书中定义；发明化合物在预防或治疗中枢神经系统疾病以及其他受mGluR5受体调节的疾病方面有用。
• ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
  申请人：Bessis Anne-Sophie

  公开号：US20110112143A1

  公开（公告）日：2011-05-12

  The present invention relates to new compounds of formula (I) wherein A, B, P, Q, W, R 1 and R 2 are defined in the description; invention compounds are useful in the prevention or treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors.

  本发明涉及公式（I）的新化合物，其中A、B、P、Q、W、R1和R2在说明书中有定义；发明的化合物在预防或治疗中枢神经系统疾病以及其他被mGluR5受体调节的疾病方面是有用的。
• METHOD FOR ACTIVATING ACTIVE HYDROGEN AND ACTIVATION CATALYST
  申请人：Nippon Shokubai Co., Ltd.

  公开号：EP1022058A1

  公开（公告）日：2000-07-26

  The ESPD charge of at least one atom in an atomic group forming a functional group included in an activating catalyst is in a range between -0.65 and -1.05 (electrons). Alternately, an activating catalyst includes a cyclic quaternary ammonium group as the functional group and the ESPD charge of a nitrogen atom forming the ammonium group is in a range between +0.4 and +1.3 (electrons). Consequently, the catalyst can efficiently activate an active hydrogen included in a compound using the atom showing the ESPD charge in the above-specified range as an active site. In other words, the catalyst can be suitably used as an activating catalyst for various reactions involving the activation of the active hydrogen. Also, by using the activating catalyst, a reaction with excellent selectivity can be conducted.

  形成活化催化剂中官能团的原子团中至少一个原子的ESPD电荷在-0.65和-1.05（电子）之间。另外，活化催化剂包括一个环状季铵基团作为官能团，形成铵基团的氮原子的ESPD电荷在+0.4和+1.3（电子）之间。因此，催化剂可以使用ESPD电荷在上述规定范围内的原子作为活性位点，有效地激活化合物中的活性氢。换句话说，催化剂可以适当地用作活化催化剂，用于涉及活化活性氢的各种反应。此外，通过使用该活化催化剂，还可以进行选择性极佳的反应。
• PROCESS FOR PRODUCING RESIN-COATED PIGMENT, RESIN-COATED PIGMENT, AQUEOUS PIGMENT DISPERSION, AND AQUEOUS COLORANT COMPOSITION CONTAINING THE SAME
  申请人：SAKATA INX CORPORATION

  公开号：EP1752500A1

  公开（公告）日：2007-02-14

  A process for producing a resin-coated pigment capable of providing an ink and a paint being superior in dispersion stability of a pigment and having rapid drying property, high gloss and density without containing those such as an organic solvent and a salt that cause the lowering of performance of pigment dispersion, characterized in that a pigment is dispersed in an aqueous solution in which an anionic group-containing resin is dissolved in the presence of a basic compound and then, the anionic group-containing resin is precipitated on the surface of the pigment by removing the basic compound in the aqueous solution, using an ion exchange means.

  一种树脂包覆颜料的生产工艺，可提供颜料分散稳定性优异、干燥性能快、光泽度和密度高的油墨和涂料，且不含导致颜料分散性能降低的有机溶剂和盐、其特征在于：将颜料分散在一种水溶液中，在该水溶液中，含有碱性化合物的阴离子树脂被溶解，然后，利用离子交换手段去除水溶液中的碱性化合物，使阴离子树脂沉淀在颜料表面。
• JAK3 SELECTIVE INHIBITOR
  申请人：Peking University Shenzhen Graduate School

  公开号：EP3805214A1

  公开（公告）日：2021-04-14

  The present invention relates to a compound of Formula (I)/(II) or pharmaceutically acceptable salts thereof. In Formula (I), Rh, Rg, Rf, m, Re, Rd, Ra, Rb, and Rc are as defined in the description. The present invention further relates to a pharmaceutical composition comprising the compound of Formula (I)/(II) or pharmaceutically acceptable salts thereof, and use of the compound of Formula (I)/(II) or the pharmaceutical composition in the manufacture of a medicament for treating inflammations such as rheumatoid arthritis.

  本发明涉及式 (I)/(II) 的化合物或其药学上可接受的盐类。在式 (I) 中，Rh、Rg、Rf、m、Re、Rd、Ra、Rb 和 Rc 如描述中所定义。本发明进一步涉及一种包含式（I）/（II）化合物或其药学上可接受的盐的药物组合物，以及式（I）/（II）化合物或药物组合物在制造治疗炎症如类风湿性关节炎的药物中的用途。