7-Bromo-1-tert-butyldiphenylsilyloxyheptane | 172995-38-9

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 7-Bromo-1-tert-butyldiphenylsilyloxyheptane
• 英文别名: 1-tert-butyldiphenylsilyloxy-7-bromoheptane；((7-bromoheptyl)oxy)(tert-butyl)diphenylsilane；7-t-butyldiphenylsilyloxyheptyl-1-bromide；7-bromoheptoxy-tert-butyl-diphenylsilane
• CAS: 172995-38-9
• 化学式: C₂₃H₃₃BrOSi
• 分子量: 433.504
• InChiKey: OGJLYJDNWBRWEY-UHFFFAOYSA-N

物化性质

• 沸点：
  448.2±37.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.91
• 重原子数：
  26
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  7-Bromo-1-tert-butyldiphenylsilyloxyheptane 在 四丁基氟化铵 、 sodium hydride 、 三乙胺 作用下， 生成 7-(4,9-Dioxopyrrolo[3,2-g]isoquinolin-1-yl)heptyl methanesulfonate
  参考文献：
  名称：

  Synthesis and antiproliferative activity of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives: Part II

  摘要：

  A series of 6-azanaphthoquinone pyrrolo-annelated derivatives carrying different basic side chains have been synthesized. The antiproliferative activities of all compounds were evaluated on at least four different cell lines with Mitoxantrone as reference compound. Cytotoxic effects and DNA intercalation behavior were investigated. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.013
• 作为产物：
  描述：

  7-溴-1-庚醇 、 叔丁基二苯基氯硅烷 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以94%的产率得到7-Bromo-1-tert-butyldiphenylsilyloxyheptane
  参考文献：
  名称：

  利用立体选择性还原π-烯丙基三羰基铁内酯配合物中的侧链羰基合成β-二吗啡酸

  摘要：

  利用π-烯丙基三羰基铁内酯配合物3来控制天然产物的所有立体化学特征的形成，可以实现β-二吗啡酸的高度立体选择性合成。

  DOI：

  10.1039/c39950001751

文献信息

• 14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) Surrogates: Carboxylate Modifications
  作者：John R. Falck、Sreenivasulu Reddy Koduru、Seetaram Mohapatra、Rajkumar Manne、Raju Atcha、Vijaya L. Manthati、Jorge H. Capdevila、Sarah Christian、John D. Imig、William B. Campbell

  DOI：10.1021/jm500262m

  日期：2014.8.28

  The cytochrome P450 eicosanoid 14,15-epoxyeicosa-5,8,11-trienoic acid (14,15-EET) is a powerful endogenous autacoid that has been ascribed an impressive array of physiologic functions including regulation of blood pressure. Because 14,15-EET is chemically and metabolically labile, structurally related surrogates containing epoxide bioisosteres were introduced and have become useful in vitro pharmacologic

  细胞色素 P450 类二十烷酸 14,15-epoxyeicosa-5,8,11-trienoic acid (14,15-EET) 是一种强大的内源性自体酸，具有一系列令人印象深刻的生理功能，包括调节血压。由于 14,15-EET 在化学和代谢上不稳定，因此引入了含有环氧化物生物电子等排体的结构相关替代物，并已成为有用的体外药理学工具，但不适用于体内应用。制备了对羧酸盐进行修饰的新一代 EET 模拟物，并评估了其血管舒张和可溶性环氧化物水解酶 (sEH) 的抑制作用。四唑19 (ED 50 0.18 μM) 和恶二唑-5-硫酮25 (ED 500.36 μM) 作为血管舒张剂的效力分别是 14,15-EET 的 12 倍和 6 倍；另一方面，它们阻断 s​​EH 的能力差异很大，即 11 与 >500 nM。这些数据将加速有效和特定体内候选药物的开发。
• [EN] MACROCYCLIC INHIBITORS OF PEPTIDYLARGININE DEIMINASES<br/>[FR] INHIBITEURS MACROCYCLIQUES DE PEPTIDYLARGININE DÉIMINASES
  申请人：GILEAD SCIENCES INC

  公开号：WO2021222353A1

  公开（公告）日：2021-11-04

  The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

  本公开涉及用于治疗与肽精氨酸脱亚氨酶（PADs）相关的疾病的新化合物，例如肽精氨酸脱亚氨酶类型4（PAD4）。本公开还涉及用于制备这些化合物的过程和中间体，使用这些化合物的方法以及包含所述化合物的药物组合物。
• Synthesis of β-dimorphecolic acid exploiting highly stereoselective reduction of a side-chain carbonyl group in a π-allyltricarbonyliron lactone complex
  作者：Steven V. Ley、Graham Meek

  DOI：10.1039/c39950001751

  日期：——

  A highly Stereoselective synthesis of β-dimorphecolic acid is accomplished utilising a π-allyltricarbonyliron lactone complex 3 to control the formation of all the stereochemical features of the natural product.

  利用π-烯丙基三羰基铁内酯配合物3来控制天然产物的所有立体化学特征的形成，可以实现β-二吗啡酸的高度立体选择性合成。
• Structure Determination of an Endogenous Sleep-Inducing Lipid, <i>cis</i>-9-Octadecenamide (Oleamide):  A Synthetic Approach to the Chemical Analysis of Trace Quantities of a Natural Product
  作者：Benjamin F. Cravatt、Richard A. Lerner、Dale L. Boger

  DOI：10.1021/ja9532345

  日期：1996.1.1

  The pursuit of endogenous sleep-inducing substances has been the focus of an extensive, complicated body of research. Several compounds, including Delta-sleep-inducing peptide and prostaglandin D-2, have been suggested to play a role in sleep induction, and yet, the molecular mechanisms of this physiological process remain largely unknown. In recent efforts, the cerebrospinal fluid of deep-deprived cats was analyzed in search of compounds that accumulated during sleep deprivation. An agent with the chemical formula C18H35NO was found to cycle with sleep-wake patterns, increasing in concentration with sleep deprivation and decreasing in amount upon recovery sleep. Since the material was generated in minute quantities and only under the special conditions of sleep deprivation, efforts to isolate sufficient material for adequate characterization, structure identification, and subsequent detailed evaluation of its properties proved unrealistic. With the trace amounts of the impure endogenous compound available, extensive MS studies on the agent were completed, revealing key structural features of the molecule including two degrees of unsaturation, a long alkyl chain, and a nitrogen substituent capable of fragmenting as ammonia. Additionally, HPLC traces suggested a weak UV absorbance for the unknown material. With this data in hand and encouraged by the relatively small size of the molecule, MW = 281, a synthetic approach toward the structural identification of the natural compound was initiated. Herein, we report the full details of the synthesis and comparative characterization of candidate structures for this endogenous agent that led to the unambiguous structural correlation with synthetic cis-9-octadecenamide.
• EP807626
  申请人：——

  公开号：——

  公开（公告）日：——