6,N,N'-trimethyl-[1,3,5]triazine-2,4-diamine | 1973-06-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 6,N,N'-trimethyl-[1,3,5]triazine-2,4-diamine
• 英文别名: 6,N²,N⁴-trimethyl-[1,3,5]triazine-2,4-diyldiamine；6,N²,N⁴-Trimethyl-[1,3,5]triazin-2,4-diyldiamin；2-Methyl-4,6-bis(methylamino)-s-triazine；N~2~,N~4~,6-Trimethyl-1,3,5-triazine-2,4-diamine；2-N,4-N,6-trimethyl-1,3,5-triazine-2,4-diamine
• CAS: 1973-06-4
• 化学式: C₆H₁₁N₅
• 分子量: 153.187
• InChiKey: FEJVUYGOBVOALE-UHFFFAOYSA-N

物化性质

• 沸点：
  326.9±25.0 °C(Predicted)
• 密度：
  1.232±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  62.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-acetyl-N'-methyl-guanidine 生成 6,N,N'-trimethyl-[1,3,5]triazine-2,4-diamine
  参考文献：
  名称：

  Traube; Gorniak, Angewandte Chemie, 1929, vol. 42, p. 381

  摘要：

  DOI：

文献信息

• Novel compositions magnetic particles covered with gem-bisphosphonate derivatives
  申请人：Port Marc

  公开号：US20100297025A1

  公开（公告）日：2010-11-25

  The invention relates to a composition comprising acid magnetic particles (p) based on an iron compound, the acid magnetic particles (p) being complexed by one or more gem-bisphosphonate compounds, of formula I: X-L-CH(PO 3 H 2 ) 2 (I) in which: L represents an organic group connecting the X group to the gem-bisphosphonate group —CH(PO 3 H 2 ) 2 ; X represents a chemical group capable of reacting with a biovector; all or some of the X groups of the particles optionally being coupled to a biovector. The invention relates also to a process for the preparation of the compositions and their use, in particular as contrast products for Magnetic Resonance Imaging (MRI).

  这项发明涉及一种包含基于铁化合物的酸性磁性颗粒（p）的组合物，所述酸性磁性颗粒（p）被一个或多个式I的双膦酸盐化合物络合： X-L-CH(PO3H2)2(I) 其中： L代表将X基团连接到双膦酸盐基团—CH(PO3H2)2的有机基团； X代表能够与生物载体发生反应的化学基团；颗粒的一个或多个X基团可选择地与生物载体偶联。 该发明还涉及一种制备所述组合物的方法及其用途，特别是作为磁共振成像（MRI）对比剂。
• THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
  申请人：AGIOS PHARMACEUTICALS, INC.

  公开号：US20160220572A1

  公开（公告）日：2016-08-04

  Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.

  提供了用于治疗癌症的化合物以及治疗癌症的方法，包括向需要治疗的受试者给予此处所述的化合物。
• Ink jet ink, ink jet recording method, ink cartridge, recording unit and ink jet recording apparatus
  申请人：Canon Kabushiki Kaisha

  公开号：EP2103659A1

  公开（公告）日：2009-09-23

  Ink jet ink providing an image having excellent lightfastness and having sticking resistance and intermittent ejection stability is provided. The ink jet ink is characterized by containing at least a compound represented by the following general formula (I) and a compound represented by the following general formula (II).

  本发明提供了一种喷墨墨水，其图像具有优异的耐光性、抗粘连性和间歇喷射稳定性。该喷墨墨水的特点是至少含有由以下通式（I）代表的化合物和由以下通式（II）代表的化合物。
• Therapeutically active compounds and their methods of use
  申请人：AGIOS PHARMACEUTICALS, INC.

  公开号：US10028961B2

  公开（公告）日：2018-07-24

  Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.

  本发明提供了用于治疗癌症的化合物以及治疗癌症的方法，其中包括向有需要的受试者施用本文所述的化合物。
• Biguanide compositions and methods of treating metabolic disorders
  申请人：Elcelyx Therapeutics, Inc.

  公开号：US10028923B2

  公开（公告）日：2018-07-24

  Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.

  本文提供了通过施用包含双胍类或相关杂环化合物（如二甲双胍）的组合物来治疗某些疾病（包括糖尿病、肥胖症和其他代谢性疾病、失调或病症）的方法。本文还提供了双胍类或相关杂环化合物组合物及其用于本发明方法的制备方法。本文还提供了包含二甲双胍及其盐类的组合物和使用方法。