1-(1-propenyl)piperidine | 24461-40-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(1-propenyl)piperidine
• 英文别名: N-(1-propenyl)piperidine；1-cis-propenyl-piperidine；1-(1-propenyl)-piperidine；N-Propenyl-piperidin；1-[(Z)-prop-1-enyl]piperidine
• CAS: 24461-40-3
• 化学式: C₈H₁₅N
• 分子量: 125.214
• InChiKey: VCQUDPHXRPHTFN-KXFIGUGUSA-N

物化性质

• 沸点：
  182.0±7.0 °C(Predicted)
• 密度：
  0.938±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(1-propenyl)piperidine 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 生成 2'-benzoyl-4't-methyl-3'r-piperidin-1-yl-spiro[fluorene-9,5'-isothiazolidine] 1'ξ-oxide
  参考文献：
  名称：

  Thione S-imides. Preparation and cycloaddition reactions

  摘要：

  DOI：

  10.1021/ja00782a069

文献信息

• NOVEL TRIAZOLE COMPOUNDS I
  申请人：Hernandez Maria-Clemencia

  公开号：US20120115844A1

  公开（公告）日：2012-05-10

  The present invention is concerned with novel triazole compounds of formula (I) wherein A, X, Y, Z, R 1 , R 2 , and R 3 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of present invention have affinity and selectivity for the GABA A α5 receptor. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.

  本发明涉及具有以下式（I）的新型三唑化合物， 其中A、X、Y、Z、R1、R2和R3如本文所述，以及其药学上可接受的盐和酯。本发明的活性化合物具有对GABA A α5受体的亲和力和选择性。此外，本发明涉及制备具有式（I）的化合物，包括它们的药物组合物以及它们作为药物的用途。
• [EN] TRIAZOLE DERIVATIVES AND THEIR USE FOR NEUROLOGICAL DISORDERS<br/>[FR] DÉRIVÉS DE TRIAZOLE ET LEUR UTILISATION POUR DES TROUBLES NEUROLOGIQUES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012062687A1

  公开（公告）日：2012-05-18

  The present invention is concerned with novel triazole compounds of formula (I) wherein A, X, Y, Z, R1, R2, and R3 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of present invention have affinity and selectivity for the GABA A α5 receptor. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.

  本发明涉及一种新型三唑化合物，其化学式为（I），其中A、X、Y、Z、R1、R2和R3如本文所述，以及其药学上可接受的盐和酯。本发明的活性化合物具有对GABA A α5受体的亲和力和选择性。此外，本发明涉及制备化合物（I）的方法，包括它们的药物组合物以及它们作为药物的用途。
• NOVEL TRIAZOLE COMPOUNDS II
  申请人：Gabriel Stephen Deems

  公开号：US20120115868A1

  公开（公告）日：2012-05-10

  The present invention is concerned with novel triazole compounds of formula (I) wherein A, X, Y, u, v, R 1 , R 2 , and R 3 are as described herein, as well as pharmaceutically acceptable salts thereof. The compounds of present invention have affinity and selectivity for the GABA A α5 receptor. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as pharmaceuticals.

  本发明涉及具有以下式(I)的新型三唑化合物，其中A、X、Y、u、v、R1、R2和R3如本文所述，以及其药学上可接受的盐。本发明的化合物对GABA A α5受体具有亲和力和选择性。此外，本发明涉及制备具有式(I)的化合物、包含它们的药物组合物以及它们作为药物的用途。
• [EN] TRIAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS<br/>[FR] DÉRIVÉS DE TRIAZOLE EN TANT QUE LIGANDS POUR LES RÉCEPTEURS GABA
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012062623A1

  公开（公告）日：2012-05-18

  The present invention is concerned with novel triazole compounds of formula (I) wherein A, X, Y, u,v, R1, R2, and R3 are as described herein, as well as pharmaceutically acceptable salts thereof. The active compounds of present invention have affinity and selectivity for the GABA A α5 receptor. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.

  本发明涉及一种新型三唑化合物，其化学式为（I），其中A、X、Y、u、v、R1、R2和R3如本文所述，以及其药学上可接受的盐。本发明的活性化合物具有对GABA A α5受体的亲和力和选择性。此外，本发明涉及制备化合物（I）、包含它们的药物组合物以及它们作为药物的用途。
• [EN] NOVEL TRIAZOLE COMPOUNDS III<br/>[FR] NOUVEAUX COMPOSÉS DE TRIAZOLE III
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012076590A1

  公开（公告）日：2012-06-14

  The present invention is concerned with novel 1,2,3-triazole-imidazole compounds of formula (I) wherein X, R1, R2, and R3 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of present invention have affinity and selectivity for the GABA A α5 receptor. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.

  本发明涉及新颖的1,2,3-三唑-咪唑化合物，其化学式为（I），其中X，R1，R2和R3如本文所述，并且其药学上可接受的盐和酯。本发明的活性化合物具有对GABA A α5受体的亲和力和选择性。此外，本发明涉及制备化合物（I）、包含它们的制药组合物以及它们作为药物的用途。