1-(3-Aminopropylamino)-3-naphthalen-1-yloxypropan-2-ol | 68575-34-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(3-Aminopropylamino)-3-naphthalen-1-yloxypropan-2-ol
• CAS: 68575-34-8
• 化学式: C₁₆H₂₂N₂O₂
• 分子量: 274.363
• InChiKey: FQBDICYEQIWWRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  67.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-(1-萘氧基)-1,2-环氧丙烷 以44%的产率得到
  参考文献：
  名称：

  RAULS D. O.; BAKER J. K., J. MED. CHEM., 1979, 22, NO 1, 81-86

  摘要：

  DOI：

文献信息

• Relationship of nonspecific antiarrhythmic and negative inotropic activity with physicochemical parameters of propranolol analogs
  作者：David O. Rauls、John K. Baker

  DOI：10.1021/jm00187a018

  日期：1979.1

  In an attempt to separate the nonspecific antiarrhythmic activity of propranolol from its negative inotropic effects, analogues containing hydrophilic and lipophilic substituents on the nitrogen and on the naphthyl ring were prepared and tested in an isolated tissue preparation. Though it had been predicted that analogues containing a very hydrophilic group on the nitrogen would have the highest antiarrhythmic/negative inotropic effect ratio, it was found that both effects increased identically when the lipophilicity of either the nitrogen or ring substituent was increased.
• RAULS D. O.; BAKER J. K., J. MED. CHEM., 1979, 22, NO 1, 81-86
  作者：RAULS D. O.、 BAKER J. K.

  DOI：——

  日期：——