1,2,3-trihydroxy xanthone | 27519-51-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1,2,3-trihydroxy xanthone
• 英文别名: 1,2,3-Trihydroxyxanthon；1,2,3-trihydroxy-xanthen-9-one；Trioxyxanthon；1,2,3-trihydroxyxanthen-9-one
• CAS: 27519-51-3
• 化学式: C₁₃H₈O₅
• 分子量: 244.204
• InChiKey: BXDRLDKJTGJUFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1,3-dihydroxy-2-acetylxanthone 在 吡啶 、 sodium hydroxide 、 双氧水 作用下， 反应 1.08h， 以65%的产率得到1,2,3-trihydroxy xanthone
  参考文献：
  名称：

  α-Glucosidase inhibition of 6-hydroxyflavones. Part 3: Synthesis and evaluation of 2,3,4-trihydroxybenzoyl-containing flavonoid analogs and 6-aminoflavones as α-glucosidase inhibitors

  摘要：

  The SAR studies suggested that the C-ring of baicalein (1) was not necessary for the activity, and validated the importance of 2,3,4-trihydroxybenzoyl structure of 1. Thus, a series of 2,3,4-trihydroxybenzoyi-containing flavonoid analogs were investigated for the alpha-glucosidase inhibitory activity. The results indicated that 5,6,7-trihydroxy-2-phenyl-4-quinolone (2) and 5,6,7-trihydroxyflavanone (4) showed the comparable activity to 1, while 3,5,6,7-tetrahydroxyflavone (7), 5,6,7-trihydroxyisoflavone (8), and 6-hydroxygenistein (9) showed moderate alpha-glucosidase inhibitory activity. In addition, it was found that 6-amino-5,7-dihydroxyflavone (16) was a more potent and specific rat intestinal alpha-glucosidase inhibitor than 1, and showed the comparable activity to acarbose. This is the first report on mammalian intestinal alpha-glucosidase inhibitory activity of 6-aminoflavones. Kinetic studies revealed that 16 inhibited both sucrose- and maltose-hydrolyzing activities of rat intestinal alpha-glucosidase uncompetitively/ (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.12.010

文献信息

• New polyester compositions; shaped articles obtained from them and processes for preparing them
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0076582A1

  公开（公告）日：1983-04-13

  A new linear polyester contains in its chain the residues of a hydroxy-bis(hydroxy-alkoxy)xanth-9-one e.g. polyethylene terephthalate containing such residues which act as a UV stabiliser. Processes for the preparation of the polymers include the reaction of a dibasic acid, glycol and 1,3,6-trihydroxyxanthone whereby only two of the xanthone hydroxyl groups take part in the polyester-forming reaction.

  新型线性聚酯的链中含有羟基-双（羟基-烷氧基）氧杂蒽-9-酮的残基，例如聚对苯二甲酸乙二醇酯中就含有此类残基，可用作紫外线稳定剂。 这种聚合物的制备工艺包括二元酸、乙二醇和 1,3,6-三羟基氧杂蒽酮的反应，其中只有两个氧杂蒽酮羟基参与聚酯形成反应。
• Agent for inhibiting binding of 5 alpha -dihydrotestosterone with androgen receptor as well as process for obtaining same
  申请人：Kabushiki Kaisha Vitamin Kenkyusyo

  公开号：EP0296625A2

  公开（公告）日：1988-12-28

  An agent for inhibiting the binding of 5α-dihydrotestosterone with androgen receptor. which comprises at least one extract from herbs or one of specific xanthone compounds, and a process for obtaining the agent.

  一种抑制 5α-二氢睾酮与雄激素受体结合的制剂，它包括至少一种草药提取物或一种特定的黄酮化合物，以及获得该制剂的工艺。
• EP0888052A4
  申请人：——

  公开号：EP0888052A4

  公开（公告）日：2002-05-22
• XANTHONE ANALOGS FOR THE TREATMENT OF INFECTIOUS DISEASES
  申请人：INTERLAB CORPORATION

  公开号：EP0888052A1

  公开（公告）日：1999-01-07
• US4456746A
  申请人：——

  公开号：US4456746A

  公开（公告）日：1984-06-26