4-乙基哌啶-2,6-二酮 | 78265-96-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 4-乙基哌啶-2,6-二酮
• 英文名称: β-Ethyl-glutarimid
• 英文别名: 4-ethyl-piperidine-2,6-dione；4-Aethyl-piperidin-2,6-dion；3-Ethylglutarimide；4-ethylpiperidine-2,6-dione
• CAS: 78265-96-0
• 化学式: C₇H₁₁NO₂
• 分子量: 141.17
• InChiKey: JOXZQJXTAKJQTF-UHFFFAOYSA-N

物化性质

• 熔点：
  84-85 °C
• 沸点：
  288.0±9.0 °C(Predicted)
• 密度：
  1.060±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2925190090

反应信息

• 作为产物：
  描述：

  3-乙基戊二酸酐 在 氨 作用下， 生成 4-乙基哌啶-2,6-二酮
  参考文献：
  名称：

  Actioneone（一种来自灰链霉菌的抗生素）的结构和化学性质。

  摘要：

  DOI：

  10.1021/ja01169a041

文献信息

• [EN] RIPK1 INHIBITORS AND METHODS OF USE<br/>[FR] INHIBITEURS DE RIPK1 ET PROCÉDÉS D'UTILISATION
  申请人：MERCK SHARP & DOHME

  公开号：WO2021252307A1

  公开（公告）日：2021-12-16

  Described herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof. The compounds of Formula (I) act as RIPK1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for RIPK1-related diseases.

  本文描述的是化合物的结构式（I）或其药用可接受的盐。式（I）化合物作为RIPK1抑制剂，可用于预防、治疗或作为RIPK1相关疾病的治疗剂。
• [EN] N-ALKYLDIAMIDE COMPOUNDS AND GELS COMPRISING THE SAME<br/>[FR] COMPOSÉS DE N-ALKYLDIAMIDE ET GELS LES COMPRENANT
  申请人：RHODIA OPERATIONS

  公开号：WO2017174615A1

  公开（公告）日：2017-10-12

  The present invention is directed to N-alkyldiamide compounds responding to the following formula (I), wherein: R1 or R2 is selected from hydrogen or a linear, branched or cyclic, saturated or unsaturated, hydrocarbon chain having from 1 to 40 carbon atoms, with the proviso that one and only one of R1 or R2 is hydrogen, R is selected from cyclic or branched, saturated or unsaturated, hydrocarbon aliphatic chain having from 2 to 15 carbon atoms. The present invention also relates to the use of the compounds of formula (I) as a gelling agent and to gel compositions comprising said compounds of formula (I).

  本发明涉及响应以下式（I）的N-烷基二酰胺化合物，其中：R1或R2选择自氢或具有1至40个碳原子的线性、支链或环状、饱和或不饱和的烃链，但R1或R2中仅有一个是氢，R选择自具有2至15个碳原子的环状或支链、饱和或不饱和的烃脂肪链。本发明还涉及将式（I）化合物用作凝胶剂以及包含该式（I）化合物的凝胶组合物的用途。
• [EN] N-HYDROCARBYLDIAMIDE COMPOSITION WITH GELATING PROPERTIES<br/>[FR] COMPOSITION DE N-HYDROCARBYLDIAMIDE POSSÉDANT DES PROPRIÉTÉS DE GÉLIFICATION
  申请人：RHODIA OPERATIONS

  公开号：WO2019068912A1

  公开（公告）日：2019-04-11

  A N-hydrocarbyldiamide composition comprising: a) a compound of formula (Ia), wherein R1 is selected from linear or branched or cyclic, saturated or unsaturated, hydrocarbon chains having from 1 to 40 carbon atoms, R2 is selected from linear or branched, saturated or unsaturated, hydrocarbon aliphatic chains having from 1 to 15 carbon atoms, and R3 is selected from linear or branched alkyl groups having from 1 to 8 carbon atoms, and b) a compound of formula (Ib), wherein R4 is selected from linear or branched or cyclic, saturated or unsaturated, hydrocarbon chain having from 1 to 40 carbon atoms, R5 is selected from linear or branched, saturated or unsaturated, hydrocarbon aliphatic chains having from 1 to 15 carbon atoms, and R6 is selected from linear or branched alkyl groups having from 1 to 8 carbon atoms said composition comprising the compounds of formula (Ia) and formula (Ib) in a molar ratio of at least 70:30.

  一种N-烃基二酰胺组合物，包括：a）式（Ia）的化合物，其中R1选自具有1至40个碳原子的线性或支链或环状、饱和或不饱和的烃基链，R2选自具有1至15个碳原子的线性或支链、饱和或不饱和的烃基链，R3选自具有1至8个碳原子的线性或支链烷基基团；b）式（Ib）的化合物，其中R4选自具有1至40个碳原子的线性或支链或环状、饱和或不饱和的烃基链，R5选自具有1至15个碳原子的线性或支链、饱和或不饱和的烃基链，R6选自具有1至8个碳原子的线性或支链烷基基团，该组合物中的式（Ia）和式（Ib）的化合物摩尔比至少为70:30。
• [EN] FORMULATIONS COMPRISING SURFACTANTS, ORGANIC LIQUIDS AND VISCOSIFIERS<br/>[FR] FORMULATIONS COMPRENANT DES TENSIOACTIFS, DES LIQUIDES ORGANIQUES ET DES AMÉLIORANTS DE VISCOSITÉ
  申请人：RHODIA OPERATIONS

  公开号：WO2019068914A1

  公开（公告）日：2019-04-11

  A non-aqueous, emulsifiable formulation comprising a) at least 3 % by weight of at least one surfactant, b) at least 10 % by weight of an organic liquid, c) at least 0.1 % by weight of at least one viscosifier selected from N- hydrocarbyldiamides or mixtures thereof.

  一种非水相、可乳化的配方，包括：a) 至少3%重量的至少一种表面活性剂；b) 至少10%重量的有机液体；c) 至少0.1%重量的至少一种从N-烃基二酰胺中选择的增稠剂或其混合物。
• [EN] FORMULATIONS COMPRISING BIOLOGICALLY ACTIVE INGREDIENTS<br/>[FR] FORMULATIONS COMPRENANT DES PRINCIPES BIOLOGIQUEMENT ACTIFS
  申请人：RHODIA OPERATIONS

  公开号：WO2019068913A1

  公开（公告）日：2019-04-11

  A non-aqueous, emulsifiable formulation comprising a) at least 3 % by weight of at least one surfactant, b) at least 10 % by weight of an organic liquid, c) at least 0.1 % by weight of at least one viscosifier selected from N- hydrocarbyldiamides or mixtures thereof, and d) at least 0.5 wt% of at least one biologically active ingredient.

  一个非水性，可乳化的配方，包括：a) 至少3%重量的至少一种表面活性剂，b) 至少10%重量的有机液体，c) 至少0.1%重量的至少一种从N-烃基二酰胺或其混合物中选择的增稠剂，以及d) 至少0.5重量%的至少一种生物活性成分。