2,5-二氧代-1-((5-((3AS,4S,6AR)-2-氧代六氢-1H-噻吩并[3,4-D]咪唑-4-基)戊酰基)氧基)吡咯烷-3-磺酸 | 190598-55-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 生物素及其衍生物
• 中文名称: 2,5-二氧代-1-((5-((3AS,4S,6AR)-2-氧代六氢-1H-噻吩并[3,4-D]咪唑-4-基)戊酰基)氧基)吡咯烷-3-磺酸
• 英文名称: sulfo-NHS-biotin
• 英文别名: sulfo-N-hydroxysuccinimido-biotin sodium salt；sulfosuccinimidyl 6-(biotinamido)hexanoate；2,5-Dioxo-1-((5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoyl)oxy)pyrrolidine-3-sulfonic acid；1-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoyloxy]-2,5-dioxopyrrolidine-3-sulfonic acid
• CAS: 190598-55-1
• 化学式: C₁₄H₁₉N₃O₈S₂
• 分子量: 421.452
• InChiKey: YCZTUBHUGXHSKE-VVCAKUBGSA-N

物化性质

• 密度：
  1.67±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  193
• 氢给体数：
  3
• 氢受体数：
  9

安全信息

• 危险性防范说明：
  P261,P264,P270,P271,P280,P301+P312,P302+P352,P304+P340,P305+P351+P338,P330,P332+P313,P337+P313,P362,P403+P233,P405,P501
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  2,5-二氧代-1-((5-((3AS,4S,6AR)-2-氧代六氢-1H-噻吩并[3,4-D]咪唑-4-基)戊酰基)氧基)吡咯烷-3-磺酸 、 3-氨基苯硼酸 以 水 为溶剂， 反应 2.0h， 生成 [3-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]phenyl]boronic acid
  参考文献：
  名称：

  Use of arylboronic acids in protein labelling

  摘要：

  本发明涉及在多肽中使用芳香硼酸标记试剂对组氨酸进行标记。本发明进一步描述了通过从单一蛋白质样品或蛋白质样品池中分离和识别含有组氨酸的肽来识别样品中蛋白质的方法和设备。本发明还描述了来自计算机模拟切割蛋白质的含有组氨酸的肽的数据库及其在蛋白质识别中的用途。

  公开号：

  EP1921081A1

文献信息

• [EN] A GENETICALLY ENCODED, PHAGE-DISPLAYED CYCLIC PEPTIDE LIBRARY AND METHODS OF MAKING THE SAME<br/>[FR] BANQUE DE PEPTIDES CYCLIQUES CODÉS GÉNÉTIQUEMENT ET EXPRIMÉS EN SURFACE DE PHAGES, ET MÉTHODES DE PRODUCTION DE CELLE-CI
  申请人：TEXAS A & M UNIV SYS

  公开号：WO2020236146A1

  公开（公告）日：2020-11-26

  Embodiments of the present disclosure pertain to methods of selecting cyclic peptides that bind to a target by transforming a phage display library with a plurality of nucleic acids into bacterial host cells, where the nucleic acids include phage coat protein genes with a combinatorial region that encodes at least one cysteine and at least one non-canonical amino acid. The transformation results in the production of phage particles with phage coat proteins where the cysteine and the non-canonical amino acid couple to one another to form a cyclic peptide library. Phage particles are then screened against the desired target to select bound cyclic peptides. Amino acid sequences of the selected cyclic peptides are then identified. Additional embodiments pertain to methods of constructing a phage display library that encodes the cyclic peptides. Further embodiments of the present disclosure pertain to the produced cyclic peptides, phage display libraries and phage particles.

  本公开的实施例涉及一种选择循环肽结合靶标的方法，该方法通过将具有编码至少一个半胱氨酸和至少一个非规范氨基酸的组合区域的噬菌体外壳蛋白基因的核酸库转化为细菌宿主细胞来实现。转化导致产生带有噬菌体外壳蛋白的噬菌体颗粒，其中半胱氨酸和非规范氨基酸耦合形成循环肽库。然后，对所需的靶标筛选噬菌体颗粒以选择结合的循环肽。然后确定所选择的循环肽的氨基酸序列。本公开的其他实施例涉及构建编码循环肽的噬菌体外显库的方法。本公开的其他实施例涉及所产生的循环肽、噬菌体外显库和噬菌体颗粒。
• BIOMOLECULE DETECTION REAGENT AND METHOD FOR DETECTING BIOMOLECULE USING THE SAME
  申请人：Hoshino Hideki

  公开号：US20090325814A1

  公开（公告）日：2009-12-31

  A biomolecule detection reagent comprising a semiconductor nanoparticle aggregate, wherein each semiconductor nanoparticle, constituting the semiconductor nanoparticle aggregate, has detection molecules binding specifically with biomolecules on its surface, and a standard deviation of numbers of the detection molecules existing on each semiconductor nanoparticle, is 5% or less.

  一种生物分子检测试剂，包括半导体纳米粒子聚合物，其中每个构成半导体纳米粒子聚合物的半导体纳米粒子在其表面具有与生物分子特异性结合的检测分子，并且每个半导体纳米粒子存在的检测分子数量的标准偏差小于或等于5%。
• CARBON NANOTUBE COMPOSITE, SEMICONDUCTOR DEVICE, AND SENSOR USING SAME
  申请人：TORAY INDUSTRIES, INC.

  公开号：US20160155948A1

  公开（公告）日：2016-06-02

  A carbon nanotube composite has an organic substance attached to at least a part of a surface thereof. At least one functional group selected from a hydroxyl group, a carboxy group, an amino group, a mercapto group, a sulfo group, a phosphonic acid group, an organic or inorganic salt thereof, a formyl group, a maleimide group and a succinimide group is contained in at least a part of the carbon nanotube composite.

  一种碳纳米管复合材料，其表面至少有一部分附着有有机物质。该碳纳米管复合材料的至少一部分含有羟基、羧基、氨基、巯基、磺酸基、膦酸基、其有机或无机盐、甲酰基、马来酰亚胺基和琥珀酰亚胺基中的至少一种官能团。
• Novel alkaline phosphatase, its production and use
  申请人：TOYO BOSEKI KABUSHIKI KAISHA

  公开号：EP0724015A2

  公开（公告）日：1996-07-31

  The present invention relates to novel alkaline phosphatase which exhibits high purity and good stability, to a method of manufacturing the same and to a method of detecting a ligand in a sample using said enzyme as a marker as well as a reagent used therefor.

  本发明涉及纯度高、稳定性好的新型碱性磷酸酶，涉及制造这种酶的方法，还涉及以这种酶为标记物检测样品中配体的方法及其试剂。
• Method for the modification of polymeric carbohydrate materials
  申请人：SWETREE TECHNOLOGIES AB

  公开号：EP1860121A2

  公开（公告）日：2007-11-28

  The invention makes available a method to introduce specific chemical groups onto the surface of any polymeric carbohydrate material to alter the physico-chemical properties of said material. In particular, the method comprises the controlled introduction of chemically-modified oligosaccharides into a carbohydrate polymer using a transglycosylating enzyme.

  本发明提供了一种在任何聚合物碳水化合物材料表面引入特定化学基团的方法，以改变所述材料的物理化学特性。具体而言，该方法包括使用转糖基化酶将化学修饰的低聚糖有控制地引入碳水化合物聚合物中。