17-Propyl-17-azapentacyclo[6.6.5.02,7.09,14.015,19]nonadeca-2,4,6,9,11,13-hexaene-16,18-dione | 103781-13-1

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 芳基四氢萘木脂素
• 英文名称: 17-Propyl-17-azapentacyclo[6.6.5.02,7.09,14.015,19]nonadeca-2,4,6,9,11,13-hexaene-16,18-dione
• CAS: 103781-13-1
• 化学式: C₂₁H₁₉NO₂
• 分子量: 317.387
• InChiKey: FDXQKASDRYXPPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6,6-二甲基-5-亚甲基-1,3-环戊二烯 、 蒽 在 porcine gastric mucin type III 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 120.0h， 生成 17-Propyl-17-azapentacyclo[6.6.5.02,7.09,14.015,19]nonadeca-2,4,6,9,11,13-hexaene-16,18-dione
  参考文献：
  名称：

  Organic Reactions Promoted by Mucin Glycoproteins

  摘要：

  Mucins are heavily glycosilated proteins that exhibit a broad range of adhesive interactions with various hydrophobic organic materials. However, there has been no clear evidence that mucins are capable of promoting chemical reactions. Here we provide the first demonstration that bovine submaxillary mucin and porcine gastric mucin accelerate the rate of fatty acid p-nitrophenol ester hydrolysis up to 337 times and a carbon-carbon bond-forming Diels-Alder reaction between N-propylmaleimide and anthracene up to 200 times relative to the rates of the reference processes, which were performed in water and chloroform, respectively. The discovered property of mucins to accelerate organic reactions provides a new and unique example of natural nonenzymatic proteins capable of promoting reactions of hydrophobic materials in aqueous solution. A better understanding of the interactions of mucins with hydrophobic molecules is needed for the development of superior drug-delivery systems and implantable devices.

  DOI：

  10.1021/ja9040626