Synthesis and Characterization of <i>N</i>-Demethylated Metabolites of Malachite Green and Leucomalachite Green
作者:Bongsup P. Cho、Tianle Yang、Lonnie R. Blankenship、Joanna D. Moody、Mona Churchwell、Frederick A. Beland、Sandra J. Culp
DOI:10.1021/tx0256679
日期:2003.3.1
protozoan infections in fish, undergoes sequential oxidation to produce various N-demethylated derivatives (monodes-, dides(sym)-, dides(unsym)-, trides-, and tetrades-) both before and after reduction to leucomalachite green (LMG). The close structure resemblance of the metabolites with aromatic aminecarcinogens implicates a potential genotoxicity from exposure to MG. The availability of the synthetic