1-(1-methyl-4-piperidyl)-2-propanone | 85704-15-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(1-methyl-4-piperidyl)-2-propanone
• 英文别名: 4-acetonyl-1-methylpiperidine；1-(1-Methylpiperidin-4-yl)propan-2-one
• CAS: 85704-15-0
• 化学式: C₉H₁₇NO
• 分子量: 155.24
• InChiKey: UIUNEEXOTSPAHL-UHFFFAOYSA-N

物化性质

• 沸点：
  215.7±13.0 °C(Predicted)
• 密度：
  0.920±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(1-methyl-4-piperidyl)-2-propanone 在 氢氧化钾 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 以68%的产率得到4-acetonyl-1-methylpiperidine N-oxide
  参考文献：
  名称：

  A new synthesis of 5-phenylmorphans1,2

  摘要：

  DOI：

  10.1016/s0040-4020(01)86738-7
• 作为产物：
  描述：

  1-(1-methyl-4-piperidylidene)-2-propanone 生成 1-(1-methyl-4-piperidyl)-2-propanone
  参考文献：
  名称：

  BONJOCH, JOSEP;CASAMITJANA, NURIA;BOSCH, JOAN, TETRAHEDRON, 44,(1988) N 6, 1735-1741

  摘要：

  DOI：

文献信息

• Long-Acting Y2 and/or Y4 Receptor Agonists
  申请人：Østergaard Søren

  公开号：US20110275559A1

  公开（公告）日：2011-11-10

  The present invention relates to a PYY or PP peptide derivative or analogue thereof derivatised with one or more serum albumin binding side chains comprising a dis-tal tetrazole or carboxylic acid group. Moreover, the invention relates to compositions hereof and methods of treatment of conditions responsive to Y receptor modulation.

  本发明涉及一种与一种或多种血清白蛋白结合侧链衍生物或类似物衍生物化合的PYY或PP肽衍生物，其中包括一个远端四唑基或羧酸基团。此外，本发明涉及这些组合物以及对于对Y受体调节敏感的病况的治疗方法。
• HETEROCYCLIC COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20170283406A1

  公开（公告）日：2017-10-05

  The present invention provides a compound having an MAGL inhibitory action, and useful as an agent for the prophylaxis or treatment of neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, glaucoma, multiple sclerosis etc.), anxiety disorder, pains (e.g., inflammatory pain, cancerous pain, neurogenic pain etc.), epilepsy, depression and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

  本发明提供了一种具有MAGL抑制作用的化合物，可用作预防或治疗神经退行性疾病（例如阿尔茨海默病、帕金森病、亨廷顿病、肌萎缩侧索硬化、创伤性脑损伤、青光眼、多发性硬化等）、焦虑障碍、疼痛（例如炎症性疼痛、癌症疼痛、神经源性疼痛等）、癫痫、抑郁症等。本发明涉及一种由下式（I）表示的化合物：其中每个符号如规范中定义，或其盐。
• Mercuric acetate cyclization of -(arylmethyl)piperidines; synthesis of indolo [,-g]morphans (tetracyclic ring system of strychnos indole alkaloids) and ,-benzomorphans
  作者：Joan Bosch、Josep Bonjoch、Anna Diez、Anna Linares、Montserrat Moral、Mario Rubiralta

  DOI：10.1016/s0040-4020(01)96488-9

  日期：1985.1

  3-g]morphans and 7,8-benzomorphans is reported. The key step in these syntheses is the mercuric acetate oxidation of appropriate 2-(4-piperidylmethyl) indoles or 4-benzylpiperidines, respectively. An alternative synthetic entry to 2-(4-piperidylmethyl)indoles, consisting in Wadsworth-Emmons condensation of a suitable 4-piperidone with diethyl 2-oxopropylphosphonate followed by catalytic hydrogenation and

  报道了一种合成吲哚[2,3-g]吗啡和7,8-苯并吗啡的新途径。这些合成中的关键步骤分别是适当的2-（4-哌啶基甲基）吲哚或4-苄基哌啶的乙酸汞氧化。描述了2-（4-哌啶基甲基）吲哚的另一种合成入口，其包括合适的4-哌啶酮与2-氧代丙基膦酸二乙酯的Wadsworth-Emmons缩合，然后将所得的4-丙酮基哌啶催化加氢和费歇尔吲哚化。
• Functionalized 2-azabicyclo[3.3.1]nonanes. IV. synthesis of the indolo[3,2-f]morphan system.
  作者：Josep Bonjoch、Nuria Casamitjana、Joan Bosch

  DOI：10.1016/0040-4020(82)85014-x

  日期：1982.1

  A short route to the 2-azabicyclo[3.3.1]nonan-7-one system is described. Condensation of 4-piperidones with diethyl 2-oxopropylphosphonate, followed by catalytic hydrogenation furnished the corresponding piperidylpropanones which were cyclized with mercuric acetate in acetic acid to the target target bicyclic ketones . The Fischer indole synthesis from afforded regioselectively the indole [3,2-f]morphan

  描述了到2-氮杂双环[3.3.1]壬南-7-一系统的短路径。将4-哌啶酮与2-氧代丙基膦酸二乙酯缩合，然后催化氢化，得到相应的哌啶基丙烷，将其与乙酸汞在乙酸中环化成目标目标双环酮。由Fischer吲哚合成可选择性地提供吲哚[3,2- f ]吗啡，一种新的异吗啡类型。
• Carboxamide Compounds and Methods for Using The Same
  申请人：Yu Jiaxin

  公开号：US20090275609A1

  公开（公告）日：2009-11-05

  Disclosed are carboxamide compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R 1 , R 2 , R 3 , R 4 , D, J, Z, T, p, q, w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

  本发明涉及羧酰胺化合物、以及制备该化合物的药物组合物和使用方法。其中一种实施例是具有以下结构的化合物，其中R1、R2、R3、R4、D、J、Z、T、p、q、w和x如本文所述。在某些实施例中，本文所述的化合物可激活AMPK途径，并可用于治疗代谢相关的疾病和状况。