1-<1-(triphenylmethyl)-1H-imidazol-4-yl>-2-butanamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-<1-(triphenylmethyl)-1H-imidazol-4-yl>-2-butanamine
• 英文别名: 1-(1-Tritylimidazol-4-yl)butan-2-amine
• 化学式: C₂₆H₂₇N₃
• 分子量: 381.52
• InChiKey: LUXUHJUWESDGCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-三苯甲基咪唑-4-甲醛 在 lithium aluminium tetrahydride 、 ammonium acetate 作用下， 以 四氢呋喃 为溶剂， 反应 8.0h， 生成 1-<1-(triphenylmethyl)-1H-imidazol-4-yl>-2-butanamine
  参考文献：
  名称：

  Synthesis and histamine H3-receptor agonist activity of mono- and dialkyl-substituted histamine derivatives

  摘要：

  In search for potential histamine H-3-receptor agonists a series of mono- and dialkyl-substituted histamine derivatives was synthesized. All target compounds were tested in vitro for their agonist activity at H-3-, H-2-, and H-1-receptors. Introduction of one ethyl or two methyl residues into histamine led to compounds with decreased histamine H-3-agonist potency in most cases. However, the non-chiral alpha,alpha-dimethylhistamine (15) was identified to be three times as active as histamine itself at H-3-receptors. In addition 15 Dimethylhistamine 23, which is a potential metabolite of (alpha R)-alpha-methylhistamine 1, proved to be inactive at all three histamine receptor subtypes.

  DOI：

  10.1016/0223-5234(96)88228-6

文献信息

• Synthesis and histamine H3-receptor agonist activity of mono- and dialkyl-substituted histamine derivatives
  作者：R Lipp、H Stark、JM Arrang、M Garbarg、JC Schwartz、W Schunack

  DOI：10.1016/0223-5234(96)88228-6

  日期：1995.1

  In search for potential histamine H-3-receptor agonists a series of mono- and dialkyl-substituted histamine derivatives was synthesized. All target compounds were tested in vitro for their agonist activity at H-3-, H-2-, and H-1-receptors. Introduction of one ethyl or two methyl residues into histamine led to compounds with decreased histamine H-3-agonist potency in most cases. However, the non-chiral alpha,alpha-dimethylhistamine (15) was identified to be three times as active as histamine itself at H-3-receptors. In addition 15 Dimethylhistamine 23, which is a potential metabolite of (alpha R)-alpha-methylhistamine 1, proved to be inactive at all three histamine receptor subtypes.